II. Updates: May 2016

  1. Brain Abscess (neuro, id, Bacteria)
    1. From Direct Spread (e.g. Mastoiditis, Sinusitis, Dental Infection) or hematogenous (e.g. empyema, endocarditis)
    2. Strep cause up to 70% of cases, and the rest are most Bacteroides, Enterobacteriaciae and Staph aureus
    3. Unilateral Headache is most common presentation, but fever, focal neurologic deficits, Seizures, aloc are variable
    4. Diagnosis is by MRI (preferred) or CT, and fluid is obtained by neurosurgery (avoid Lumbar Puncture)
    5. Initial empiric antibiotic management includes Cephalosporin and Metronidazole and consider Vancomycin
  2. Aseptic Meningitis (neuro, id)
    1. Enteroviruses cause 85% of cases, in addition to Arbovirus, Herpes viruses, HIV
    2. Bacterial causes include Brain Abscess, partially treated Meningitis, Lymes, Tuberculosis
    3. Other causes include fungal Meningitis, medications (esp. Ibuprofen), Leukemia, lumphoma and Autoimmune Conditions
    4. Abnormal brain function (aloc, changed behavior, personality, speech) distinguishes Encephalitis from Meningitis
    5. Seizures may occur with either Meningitis or Encephalitis
  3. Encephalitis (neuro, id)
    1. More than 40% of cases are HSV Encephalitis; other causes VZV, Tb, Listeria, Arbovirus
    2. NMDA Encephalitis is a common cause in age <30 years old (40% of cases in one study)
    3. Start Acyclovir empirically in all cases of suspected Encephalitis until HSV is excluded by PCR
  4. Bacterial Meningitis Management (neuro, id, Bacteria)
    1. For over age 1 month, empiric management includes Vancomycin AND Cefotaxime OR Ceftriaxone (or Meropenem)
    2. Dexamethasone is added for suspected pneumococcus
    3. Ampicillin is added for listeria risk (immunocompromised, pregnant, over age 50 years or under age 1 month)
  5. Bartonella (id, Bacteria)
    1. Three species of Gram Negative Rod cause Cat Scratch Disease, Bacterial Endocarditis, Trench Fever and Bacillary Angiomatosis
    2. Bartonella is a common cause of culture negative endocarditis (esp. in homeless)
    3. Bacillary Angiomatosis complicates AIDS (CD4 <100) with vascular lesions similar to Kaposi's Sarcoma (may disseminate)
  6. Health Concerns in the Elderly (geri, prevent)
    1. Take Life Expectancy into account when discussing cancer screening
    2. Paradoxically, the healthiest patients are screened less than those in with the lowest Life Expectancy
  7. Adnexal Mass (gyn, ovary)
    1. Most Ovarian Masses are benign, and routine screening for Ovarian Cancer is not recommended in low risk patients
    2. Obtain a Pregnancy Test (to exclude Ectopic Pregnancy) in all women with a Uterus of child bearing age
    3. Ovarian Cancer risk increases after age 40-50, FHx (esp. BRCA, Lynch syndrome), nulliparity, Obesity
    4. Red flag symptoms with Ovarian Mass include abdominal bloating, pelvic or Abdominal Pain, urinary symptoms
  8. Ovarian Torsion (gyn, ovary)
    1. Torsion presents in atypical patients (15% pediatric, 15% postmenopause, 20% pregnancy, 25% without risk)
    2. Torsion presents with atypical symptoms (not abrupt in 40%) and pelvic exam adds little to the diagnosis
    3. Ultrasound sensitivity is poor (30-85%), not much better than CT, but is sufficient in moderate suspicion
    4. Ultrasound need not follow CT to specifically evaluate torsion in moderate suspicion cases
    5. Only definitive diagnosis tool is laparoscopy in high suspicion cases
  9. Glaucoma (eye, iop)
    1. Glaucoma is a leading cause of blindness, with increased risk especially over age 65 and in black and hispanic patients
    2. Primary Open Angle Glaucoma (POAG) is typically asymptomatic until severe visual field or central loss occurs
    3. IOP measurement alone is insufficient for POAG diagnosis (also requires Optic Nerve exam and visual field testing)
    4. More than half of POAG patients have normal IOP, and most with high IOP >22 do not develop Glaucoma (nerve injury)
  10. Cervical Radiculopathy (ortho, c-spine)
    1. Spondylosis in older patients is most common cause, especially at C6-7
    2. Loss of Triceps Reflex is most common objective finding
    3. Provocative tests with high efficacy: Spurlings Test, Shoulder Abduction Test, Upper Limb Tension Test
    4. Consider red flags including myelopathy (decreased dexterity, urine urgency, Ataxia, Clonus, hyperreflexia)
    5. MRI has a high false positive and False Negative Rate in Cervical Radiculopathy
    6. Non-surgical management is preferred in most cases (88% are improved by 4 weeks)
  11. Prostate Cancer Survivor Care (urology, Prostate, hemeonc)
    1. Obtain PSA every 6-12 months for 5 years after treatment and refer if >1.0 after radiation or >0.03 after surgery
    2. Refer for new onset Hematuria (esp. after Radiation Therapy due to secondary cancer risk)
    3. Radiation Therapy and Prostatectomy are both complicated by urinary dysfunction and Erectile Dysfunction
  12. Breast abscess (gyn, Breast, id)
    1. Needle aspiration under Ultrasound guidance is preferred (consider irrigating through same needle)
    2. Needle aspiration may be repeated as needed (consider Incision and Drainage if more than 3 times)
  13. Abdominal Aortic Aneurysm (surgery, gi, cv)
    1. Cryptic presentations are common
    2. AAA may present with Microscopic Hematuria (leading to mis-diagnosis of Renal Colic)
    3. Misdiagnosis as Diverticulitis, GI Bleed, Musculoskeletal cause is common (60% initial misdiagnosis rate)
  14. Pediatric Trauma (er, Trauma, peds)
    1. Chest XRay is preferred over chest CT in most cases of Pediatric Trauma (including Seat Belt Sign)
  15. Concussion (neuro, Trauma)
    1. No patient should return to play on the same day of a Concussion
    2. Graded Return to Play after Concussion (6 steps) is recommended for sports-related Concussion
    3. Headache, Dizziness, inattention start to improve in first 48 hours, and typically last 1-2 weeks
    4. More than 30% of patients will have Postconcussion Syndrome lasting 3 months
    5. Early cognitive and physical relative rest reduces the risk of long-lasting Concussion symptoms
  16. Severe Head Injury (neuro, Trauma)
    1. Document Neurologic Exam before intubation and use short acting sedatives
    2. Consider non-convulsive Status Epilepticus (extremity fine Tremor, facial tics)
    3. Elevate the head above 30 degrees
    4. Keep Oxygen Saturation >90% (best 94-97%) and avoid hyperoxygenation
    5. Keep Glucose in normal range
  17. Seat Belt Sign (gi, Trauma)
    1. Abdominal seat belt Ecchymosis is associated with significant Abdominal Injury in 65% of cases (RR 8)
    2. CT Abdomen is indicated in most if not all cases, and laparotomy if positive
    3. Observation for 12-24 hours with serial exams may be indicated even if normal CT Abdomen
  18. Acute Pain Management in Children (pharm, analgesia, peds)
    1. Children's pain is frequently under-treated in the emergency department
    2. Pain Evaluation scales include FLACC Scale and Wong-Baker FACES Pain Rating Scale
    3. Beyond Ibuprofen or Tylenol, oral options include Hydrocodone, Oxycodone and morphine
    4. Intranasal Fentanyl is an excellent option for children in the emergency department
    5. IV non-Opioids include Ketorolac and Ketamine, and Opioids include morphine and Hydromorphone
  19. Chest Pain (cv, cad, sx)
    1. Four factors increase the likelihood of Acute Coronary Syndrome
    2. Pain radiation to the right chest or bilateral chest
    3. Exertional Chest Pain
    4. Pain with diaphoresis
    5. Pain associated with Nausea or Vomiting
  20. Shock (cv, er)
    1. Consider intubation if Resuscitation is unlikely to result in early response (within 15 minutes)
    2. Ketamine is an ideal RSI agent for a patient in shock
  21. High Risk Acute Coronary Syndrome Management (cv, cad)
    1. Aggressively decreasing door to balloon time is associated with significant adverse effects
    2. Higher False Positive Rate on angiography (with higher mortality risk)
    3. Missed alternative diagnoses (e.g. Pulmonary Embolism, Aortic Dissection, Sepsis)
    4. Obtain an adequate initial history and examine the EKG carefully
  22. Vasopressor (cv, pharm)
    1. Peripheral Vasopressor delivery appears safe for short-term use (e.g. 2 hours)
    2. Do not use Vasopressors via unreliable, small or deep peripheral site
    3. Monitor peripheral IV closely for Vasopressor Extravasation
    4. In case of extravasation, withdraw residual Vasopressor, and inject phentolamine SQ
  23. Antivenin for Snake Bite (er, Trauma, bite, toxin)
    1. Antivenin is given as 4-6 vials over 1 hour for advancing swelling or Platelet Count or Fibrinogen <100
    2. Repeat antivenin hourly until advancing swelling ceases
    3. Recheck Platelet Count 7-10 days after Rattlesnake bite (due to delayed Thrombocytopenia risk)
  24. Acute Pain Management (pharm, Analgesic, Opioid)
    1. Limit acute Opioids to 3-7 days (most chronic use or misuse starts with acute pain prescription)
    2. Avoid Chronic Opioid dosing >50 mg/day morphine equivalents (and especially >90 mg/day)
    3. Wean Chronic Opioids if function does not improve at least 30% while on Opioids
  25. Metformin (endo, dm, pharm)
    1. Consider serum B12 level q3 years with longterm use, esp. in elderly, PPI use and vegetarians
    2. Consider B12 Deficiency for new onset Neuropathy in Diabetes Mellitus
  26. Diabetes Mellitus Glucose Management (endo, dm, pharm)
    1. Intensive diabetes control benefits Type I but not Type II
  27. Depression in Older Adults (psych, depression, pharm)
    1. Consider starting low dose Methylphenidate with SSRI for first 2-3 months in severe depression
  28. Streptococcal Pharyngitis (ent, throat, Bacteria)
    1. Strep culture may not be needed, given low risk of Rheumatic Fever, Test Sensitivity of 86% of quick strep test
    2. Preventing each case of Rheumatic Fever in U.S. costs $8 Million
  29. Acute Low Back Pain Management (ortho, l-spine)
    1. NSAIDS alone are as effective as when combined with Opioids or Flexeril
    2. Acetaminophen and early physical therapy adds little additional benefit to Acute Low Back Pain
  30. Antibiotic coverage review (id, pharm, Bacteria)
    1. Reviewed and updated infections: CV, CNS, Febrile Syndromes
    2. Covered Toxic Shock Syndrome, Septic Shock, Typhoid Fever, Enteric Fever
  31. Medication updates (er, pharm, toxin)
    1. Avoid Flumazenil in most cases of Overdose (risk of severe Benzodiazepine Withdrawal, Seizures)
    2. In Digoxin Toxicity and Hyperkalemia, Calcium is unlikely to cause harm (theoretical stone heart)
    3. Direct Oral Anticoagulants (DOACs) have significant drug interactions, albeit less than Warfarin
    4. Herbals (e.g. St Johns Wort, Glucosamine, Ginkgo) have significant drug interactions
    5. Fasting in Diabates Mellitus updated
    6. Ortho Evra corrected (weekly application, thanks to email from Kyle Walsh)
  32. Pinworms (gi, id, parasite)
    1. Drug company Impax has significant nerve charging $600-700 for old drugs (Albendazole, Mebendazole)
  33. Emergency Department Active Labor Presentation (ob, ld)
    1. Reviewed history, exam and complication management
  34. G-Tube (gi, procedure)
    1. Insertion procedure updated
  35. Bacterial Infection (id, Bacteria)
    1. Basic list of Bacteria by morphology and staining (side of effect of creating Microbe Hunter game - see Web Apps)

III. Updates: April 2016

  1. Nephrotic Syndrome (renal, urology, Proteinuria)
    1. Although numerous secondary causes (esp. DM, SLE), up to 80-90% of cases are idiopathic
    2. Edema, hypoalbuminemia (<2.5 g/dl) and Proteinuria (>3 g/day) are required for diagnosis
    3. Complications include VTE, Infection, Hyperlipidemia and Renal Failure (ESRD)
    4. May restrict Sodium (<3 g/day) and fluid (<1.5 L/day), and use ACE/ARB, Loop Diuretic and immunosuppressant
    5. ESRD occurs in 30% of Membranous Nephropathy and >50% of Focal Segmental Glomerulosclerosis
  2. Endometrial Cancer (gyn, hemeonc, Uterus)
    1. Most common gynecologic cancer, with 90% diagnosed after age 50 years old
    2. Majority of cases (75%) are Type I, Endometrioid associated with Endometrial Hyperplasia
    3. Lynch Syndrome (hereditary nonpolyposis Colorectal Cancer, HNPCC) causes 15% of cases, but 40% of mortality
    4. Screen if HNPCC, Postmenopausal Bleeding (or discharge), Anovulatory Bleeding over age 35 years, Pap Smear with AGUS
    5. Staging system was last updated 2009 and directs Hysterectomy, radiation, adjuvant agents
  3. Alcohol Use Disorder (psych, cd)
    1. DSM-V combined abuse and dependence under a single diagnosis (Alcohol Use Disorder)
    2. Preferred Alcohol Abuse Screening tools per USPTF: AUDIT, AUDIT-C and single question screening
    3. Preferred medications for maintaining abstinence are Naltrexone and Acomprosate (Campral), both generic
  4. Recurrent UTI (uro, id, Bacteria)
    1. Confirm Recurrent UTI (2 in 6 months, 3 in 12 months) with at least one Urine Culture
    2. No UTI preventive benefit to wiping front to back, hydrating, cotton underwear, or avoiding hot tub and tampons
    3. Further evaluate Hematuria, multi-drug resistance, recurrent Pyelonephritis, urinary obstructive symptoms
    4. Further evaluate prior GU malignancy, surgery, Trauma, Diverticulitis, urinary calculi
    5. Consider UTI continuous (6 months) or post-coital prophylaxis (within 2 hours) with Macrobid or Septra
    6. Consider self-start antibiotics for classic UTI symptoms in healthy women without red flags (e.g. fever, Vaginitis)
  5. Drowning (sports, water, er)
    1. Drowning is preventable, yet kills >4000 in U.S. per year, most under age 14
    2. Submersion >6 min is associated with poor prognosis, and 0% survival after 60 min
    3. Despite case reports, lung injury is just as severe in cold water and in fresh water
    4. Drownings classified as death, Grade 6 (CPR), Grade 5 (apnea), Grade 4 to 2 (rales), Grade 1 (cough) and rescue
  6. Oppositional Defiant Disorder (peds, behavior, psych)
    1. DSM-5 criteria are nearly identical to DSM-4, but now a patient may have both ODD and Conduct Disorder
    2. On spectrum of distinct disorders from typical teen to ODD to Conduct Disorder, and in adults antisocial disorder
    3. Typical onset in early elementary; distinguish from learning and language disorders, and Mood Disorders
    4. Treatment includes both child and parent training and treatment of comorbid ADHD and Major Depression
  7. Emergency Medical Service Contact (er, manage)
    1. Ambulance diversion should be avoided if possible (esp. hospital owned Ambulances)
    2. Patients may refuse Ambulance transport if they have medical decision making capacity (know risk, benefits, alternatives)
    3. Best to convince a patient to be transported voluntarily (instead of against their will with police)
  8. Difficult Intravenous Access in Children (er, procedure, peds, fen)
    1. Consider peripheral IV at distal saphenous vein, external Jugular Vein or scalp vein (not over Anterior Fontanelle)
    2. Consider intraosseous line at anterior tibia or proximal Humerus (or in a newborn, distal femur)
    3. Consider Central Line in failed IV/IO access; femoral line is preferred central access in children older than 7 days
    4. Consider Umbilical Vein Catheter in newborns under age 7 days
  9. Burn Injury (er, derm, environ)
    1. Burn Injury is frequently overestimated (esp. in children) and may result in significant overestimation of fluid requirements
    2. Only second/Third Degree Burns count toward burn percentage calculation, and Parkland Formula applies to >20% burns
    3. Lactated Ringers is the preferred fluid in burns (due to high volume fluids and hyperchloremic Metabolic Acidosis risk)
    4. Consider early intubation in Smoke Inhalation, and use ET Tube at least 7.5 mm to allow suctioning, bronchoscopy
    5. Altered Level of Consciousness in Burn Injury or Smoke Inhalation suggests CO or Cyanide Poisoning or Trauma
    6. Compartment Syndrome in Burn Injury does not occur in the first 2 hours (and typically not for 4-6 hours)
  10. Ultrasound Guided Regional Anesthesia (surgery, anesthesia, Ultrasound)
    1. Ultrasound Guided Regional Anesthesia is preferred with fewer complications and more site options than landmark-based
    2. Local Anesthetic System Toxicity (LAST) from IV anesthetic injection (esp. Bupivicaine) may cause Seizures, arrhythmias or Cardiac Arrest
    3. LAST is treated with Intralipid, Benzodiazepines for Seizures and Advanced Airway management
    4. Due to risk of LAST, Intravenous Access and available Intralipid is recommended preparation for regional Nerve Block
  11. Anticholinergic Toxicity (neuro, er, toxin)
    1. Control secondary Agitated Delirium with Benzodiazepines, not with Physical Restraints or Antipsychotics
    2. Control hyperthermia, observe for Rhabdomyolysis and administer intravenous crystalloid
    3. Physostigmine is indicated in cases refractory to Benzodiazepines
  12. Emergency Transvenous Pacing (cv, procedure, ekg)
    1. In Unstable Bradycardia, consider as an alternative to transcutaneous pacing (less energy, less Sedation)
    2. Place 6 Fr Central Line in pacing kit (instead of 9 Fr) at right internal jugular or left subclavian
    3. Pacer wire is floated with balloon into right ventricle until electrical and mechanical capture is achieved
  13. Push Dose Pressors (cv, pharm, Hypotension)
    1. Consider if Hypotension occurs with intubation in Sepsis
  14. Proton Pump Inhibitors (gi, pharm)
    1. Dementia association with longterm PPI in observational studies
  15. Penetrating Trauma (er, Trauma)
    1. FAST Exam is highest yield (Pericardial Effusion, Pneumothorax, Hemothorax, intraabdominal bleeding)
    2. Decompress Hemothorax or Pneumothorax (Ultrasound is sufficient to make diagnosis)
    3. Immediate Emergency Thoracotomy for Pericardial Effusion and loss of pulses
  16. Atypical Antipsychotics (psych, pharm, Psychosis)
    1. Olanzapine, Ziprasidone, Aripiprazole and Risperidone have been used parenterally for acute agitation
    2. Potential for serious adverse effects despite their lower risk than first generation agents (e.g. Haloperidol)
    3. Serious adverse effects include Neuroleptic Malignant Syndrome (NMS) and QTc Prolongation
    4. Extrapyramidal Side Effects and Anticholinergic side effects may also occur with Atypical Antipsychotics
    5. Clozapine has the highest risk of NMS, Agranulocytosis and Myocarditis
  17. Phytophotodermatitis (derm, environ, pharm)
    1. Sunburn precipitated by topical (or ingested) Photosensitizer (e.g. lime or lemon)
    2. Use Sunscreen, eliminate Photosensitizer and if inflamed, Topical Corticosteroid
  18. Subarachnoid Hemorrhage (neuro, cv, bleed)
    1. In suspected SAH, when CT Head is negative, LP is a true positive in 0.4%, and false positive in 4.2%
  19. Needlestick Injury (id, prevent)
    1. Highest infection risk is for an HBab negative exposed patient (30% risk if source is HBeAg positive)
    2. For a positive source, HCV transmission is 1.8% and HIV Transmission is 0.3%
    3. Post-exposure Prophylaxis is available for HIV and HBV exposures
  20. Methadone in Chronic Pain (pharm, analgesia, Opioid)
    1. Methadone is reponsible for 30% of Opioid prescription related deaths, but accounts for only 2% of the prescriptions
    2. Prescribe Naloxone Auto-Injector, and caution patients not to use Alcohol or Benzodiazepines with Methadone
    3. Methadone has a very long half-life with delayed respiratory depression
    4. Sedation that precedes pain relief suggests Methadone dose too high (taper down)
  21. Potassium Supplementation (renal, pharm, Potassium)
    1. Extended release Potassium tablets are preferred over powder (better tasting, $15 instead of $290 per month)
    2. Immediate release Potassium powder is indicated in Feeding Tubes and those with delayed gastric emptying
  22. Massive GI Bleed (gi, sx, bleed, er)
    1. Assume Upper GI Bleed in unstable patients
    2. In Massive Hemorrhage, replace blood with blood (initially with Type O, universal donor)
    3. ABC Management, early intubation, reverse coagulopathy, empiric PPI IV and variceal management
  23. Esophageal Balloon Tamponade (gi, esophagus, procedure, er)
    1. Balloon Tamponade temporizes in 60-90% until emergent endoscopy in exsanguinating Esophageal Varices
    2. Critical that gastric balloon is not inflated within esophagus (would result in Esophageal Rupture)
  24. Zika Virus (id, virus)
    1. Zika is an Arbovirus in the genus Flavivirus, which also includes Yellow Fever and Dengue Fever
    2. Transmitted by aedes Mosquito which breed in water containers
    3. Mild symptoms (if any) include fever, maculopapular rash, Arthralgia, Conjunctivitis (as well as myalgias and Headache)
    4. Associated with Guillain-Barre Syndrome and thousands of Microcephaly newborn cases in Brazil

IV. Updates: March 2016

  1. Bleeding Disorder (hemeonc, coags, bleed)
    1. Platelet Closure Function Test is no longer recommended for Bleeding Disorder evaluation
    2. When INR, PTT and Platelets are normal, obtain Von Willebrand Factor, activity and Factor VIII levels
    3. ISTH Bleeding Assessment Tool (ISTH-BAT) screens for congenital Bleeding Disorder (but not platelet function abnormality)
  2. Pediatric Anemia (hemeonc, peds, Anemia)
    1. Anemia Screening (Hgb) is now recommended universally at 12 months by WHO, AAP (but not USPTF)
    2. Mild Microcytic Anemia may be treated empirically as Iron Deficiency Anemia for one month (expect 1 g/dl increase)
    3. In Microcytic Anemia, Mentzer Index (MCV/RBC) is <13 mg/dl in Thalassemia and >13 mg/dl in Iron Deficiency Anemia
  3. Chronic Prostatitis (urology, Prostate, id)
    1. Chronic Prostatitis (symptoms >3 months) are Chronic Bacterial Prostatitis or chronic Nonbacterial Prostatitis
    2. Treat Chronic Bacterial Prostatitis (>3 months, UC positive for same organism) with Fluoroquinolone for 4-6 weeks
    3. Chronic Nonbacterial Prostatitis is treated symptomatically (e.g. Alpha Adrenergic Antagonist, Tricyclic Antidepressants)
  4. Hyperthyroidism (endo, Thyroid)
    1. Graves specific signs include Graves Ophthalmopathy, pretibial swelling, Digital Clubbing and Vitiligo
    2. Thyroiditis is self limited, resolving within 6 months and is NOT an indication for antithyroid medications or ablation
    3. Moderate to Severe Graves Ophthalmopathy is a contraindication for I-131 treatment
    4. Antithyroid agent monitoring is primarily with Free T4 and Free T3 unless symptoms prompt CBC, LFTs
    5. Thyroid Storm may be diagnosed via the Burch Watofsky Score and a specific treatment protocol is established
  5. Mechanical Ventilation (lung, er, failure)
    1. Initial Ventilator settings follow one of two "recipes" per Scott Weingart, MD at EM:Crit
    2. Acute Lung Injury: Set AC with 6 cc/kg TV, 18 RR, FIO2 and PEEP titrated together, and IFR 60-80
    3. Obstructive Lung: Set AC with 8 cc/kg TV, 10-12 RR, start FIO2 at 40%, No PEEP, and IFR 80-100
  6. Skull Trephination (neuro, bleed, surgery)
    1. Acute Subdural Hematoma or Epidural Hematoma are treated with emergent Skull Trephination in
    2. Rapidly decompensating patients with Herniation may require non-neurosurgeon trephination if any delay to neurosurgery
  7. Aortic Stenosis (cv, valve)
    1. Asymptomatic Aortic Stenosis with or without valve replacement confers similar mortality to those without Aortic Stenosis
    2. However, once even subtle symptoms arise, mortality risk sky-rockets (>50% in 2 years)
    3. Evaluate undiagnosed Grade 3, harsh, holosystolic or late Systolic Murmurs
  8. Pulmonary Embolism in Pregnancy (lung, cv, hemeonc, ob)
    1. PE Risk in pregnancy was over-estimated due to combining with DVT (accounts for 33% of VTE in pregnancy)
    2. PE Risk is 3 in 10,000 overall in pregnancy, with highest risk postpartum (esp after Cesarean Section)
    3. Start evaluation with bilateral leg venous doppler, then PERC Rule negative or D-Dimer
    4. If D-Dimer above discriminatory levels adjusted for pregnancy or high suspicion, then CTA (or perfusion only VQ Scan)
  9. Subsegmental Pulmonary Embolism Management (lung, cv, hemeonc)
    1. CT Chest has false positives (subsegmental PE re-read as negative in as many as 26% of cases)
    2. CT Chest has false negative (CT read as subsegmental PE, later re-read as segmental in 11% of cases)
    3. Subsegmental Pulmonary Embolism treatment has mixed results on outcomes
  10. ACE Inhibitor Angioedema (er, allergy, pharm)
    1. Icatibant did not show benefit in subsequent Phase III trial (initial trial results were promising)
  11. Burn Injury (er, Trauma, derm, environ)
    1. Estimate burn area only based on second and Third Degree Burns (not red, Sunburn-like injury areas)
    2. Debride large Blisters with thin walls and those over joints (aspirate large Blisters with thick walls)
    3. Silvadene delays healing, increases scar risk and is best avoided in Second Degree Burns (but preferred in third degree)
    4. Foot burn injuries in Diabetes Mellitus have 15% risk for infection and should be re-examined every 3-4 days
  12. Cardiopulmonary Resuscitation (er, cv)
    1. First 2-3 minutes prior to patient arrival is critical to successful Resuscitation and survival
    2. Gather Resuscitation team together prior to Ambulance arrival, assign roles and prepare equipment
    3. Mnemonic AEIOU: Advanced Airway, ETCO2, IO, Organize, Ultrasound
    4. Give paramedics primary attention to relay history, findings, Resuscitation efforts, and answer team questions
  13. Sepsis (id, fever, er, Bacteria)
    1. Consider initial antibiotics that may be given as IV bolus (beta-lactams, Cephalosporins, Aminoglycosides)
  14. Pediatric Sepsis (id, fever, er, Bacteria)
    1. Epinephrine may be preferred over Dopamine in cold shock (if central Intravenous Access) - higher survival rate
  15. Chronic Pelvic Pain in Women (gyn, sx, pain)
    1. Start with systematic approach with thorough history, exam, labs (e.g. hcg, GC/Ch, UA) and Transvaginal Ultrasound
    2. Laparoscopy for persistent, severe idiopathic pain refractory to Analgesics, hormonal and neuropathic agents
  16. Thrombocytopenia (hemeonc, platelet)
    1. Emergent causes of Thrombocytopenia include HUS, TTP, DIC, HIT and HELLP Syndrome
    2. Hemolytic Uremic Syndrome (HUS) is fever, Hemolytic Anemia, Renal Failure and often preceded by EHEC
    3. Thrombotic Thrombocytopenic Purpura (TTP) is fever, Hemolytic Anemia, Renal Failure, and neurologic signs
    4. Precautions
    5. Distinguishing Grade of sprain is initially difficult in first week (swelling interferes with laxity testing)
    6. If red flags, despite negative xray, safest to posterior splint, Crutches and follow-up in 7-10 days
  17. Ankle Sprain (ortho, ankle, sports)
    1. Treat suspected Grade III Lateral Ankle Sprain with posterior splint, Crutches for 7-10 days, then re-XRay, exam, air splint, PT
    2. For dynamic Splinting, air splint is preferred, allowing for dorsiflexion and plantar flexion, while providing stability
  18. Syncope (cv, sx)
    1. Presyncope has same adverse event risks as Syncope and should be evaluated in similar fashion
    2. Careful history, exam, and ekg should direct limited diagnostics and disposition
    3. Base lab ordering on symptoms, exam risks (chem8, Hgb, hcg, cxr, Troponin are not needed in every case)
    4. Rule of 15s: PE, Dissection, AAA, ectopic, SAH, ACS each have a 15% Incidence as syncopal presentation
    5. EKG may find VT, Brugada Syndrome, WPW (short PR), Prolonged QTc >500, Hypertrophic Cardiomyopathy, ischemia
    6. Abnormal vitals, EKG (including QTc>500) and Syncope WITHOUT prodrome all warrant telemetry admission
  19. Video Laryngoscopy (lung, failure, procedure)
    1. Top devices include Glidescope (hyperangulated), Storz C-Mac (DL with video), McGrath (portable)
    2. All devices offer excellent visualization (Grade I or II) even in difficult airways, and have high success at DL rescue
    3. With Glidescope use hyperangulated stylet or curved Elastic Bougie, and withdraw stylet 5 cm after passing cords
    4. Also with Glidescope, avoid inserting blade too close to cords (too hard to pass ET Tube) - keep view wide
  20. RSV Bronchiolitis (lung, Bronchi, id, peds)
    1. Central apnea risk in RSV is unlikely after 6 weeks of age or birth weight >2.5 kg (unless prior apneic event)
  21. Central Line (er, cv, procedure)
    1. In 2015 study, femoral lines had similar risks to internal jugular: infection rate (1.2%), thrombus rate (1.4%)
    2. Femoral also had the lowest failed placement rate (5%) compared with 9% IJ and 15% subclavian
  22. Intravenous Crystalloid (er, fen)
    1. Either NS or buffered solution (e.g. LR, Plasmalyte) are suitable for non-massive Fluid Replacement
    2. No increased Acute Kidney Injury or mortality with Normal Saline compared with buffered solution
  23. Emergency Management of Asthma Exacerbation (lung, Asthma)
    1. Dexamethasone 0.3 mg/kg x1 dose is as effective as Prednisolone 1 mg/kg for 3 days in moderate exacerbation
  24. Purpura (hemeonc, derm)
    1. In fever with toxicity consider Meningococcus, pneumococcus, DIC, Rocky Mountain Spotted Fever
    2. During or after viral illness or URI, consider EBV, Adenovirus, Pertussis, Strep Throat, HSP
  25. Angiotensin Receptor Blockers (cv, pharm, htn)
    1. Appear as effective as ACE Inhibitors in cardiovascular disease
  26. Anticoagulation in Thromboembolism (hemeonc, cv, pharm)
    1. Chest guidelines give the nod to Direct Oral Anticoagulants (esp. Eliquis, Xarelto)
    2. But, still no reversal agents yet, and use Warfarin instead in GFR<30, mechanical Heart Valves
  27. CVA Thrombolysis (neuro, cv, pharm)
    1. New push to use TPA in less severe strokes (NIH Stroke Score <5) within 3 hours
    2. Still I worry about the bleeding risks and the weak evidence for better outcomes
  28. Attention Deficit Medication (peds, neuro, learning, pharm)
    1. New (i.e. expensive) and old (i.e. generic) ways to get XR meds to children who will not swallow pills

V. Updates: February 2016

  1. Acute Bacterial Prostatitis (uro, Prostate, id)
    1. Accounts for only 10% of Prostatitis, but may be associated with bacteremia or Sepsis
    2. Urinalysis and Urine Culture, and PCR for GC and Chlamydia if STI risks (or age<35)
    3. Consider Blood Culture, Lactic Acid, CBC, BMP in fever >101, SIRS, immunocompromised
    4. Evaluate for Prostate abscess (transrectal Ultrasound or CT or MRI Pelvis) if refractory after 36 hours
    5. Antibiotic selection based on STI risk, outpatient, inpatient, severe (Sepsis), and Antibiotic Resistance risk
    6. Transrectal biopsy, transurethral instrumentation and Fluoroquinolone exposure modify antibiotic selection
  2. Diabetes Screening (endo, dm)
    1. Type II DiabetesPrevalence from 5 M (1980), to now 22 M + 8 M undiagnosed (9% of adults) to 44 M by 2035
    2. Screen obese adults 40-70 (every 1-3 years) and obese children (every 2 years after age 10), or other risk factors
    3. High risk ethnicity (black, native american, native alaskan, asian, hispanic, pacific islander or native hawaiian)
    4. Type II Diabetes is diagnosed with A1C >6.5%, Fasting Glucose >126 mg/dl, OGTT or random Glucose >200 mg/dl
    5. Hemoglobin A1C is modified falsely by Anemia, liver and Kidney disease, Antiretrovirals, Vitamin E and C
  3. Hypertension in Pregnancy (cv, htn, ob)
    1. Blood Pressure is only mildly increased in 30-60% of Eclampsia
    2. HELLP Syndrome may be associated with normal Blood Pressure in 13-18%, and no Proteinuria in 13%
    3. Delivery by 37 weeks gestation is recommended even in non-Severe Preeclampsia
    4. Magnesium Sulfate is recommended only in Severe Preeclampsia or Eclampsia
  4. Foot Fractures (ortho, foot, Fracture)
    1. Non-displaced Metatarsal Fractures (or displaced <3mm, angulation <10 deg) are splinted, then short leg boot, then rigid shoe
    2. Fifth Metatarsal tuberosity avulsion Fractures are in Short Leg Boot for 2 weeks, then gradual transition to ambulation
    3. Fifth Metatarsal Jone's Fracture or Diaphyseal Fracture require non-weight bearing Short Leg Cast for 6-8 weeks minimum
    4. Great Toe Fractures are immobilized in short leg boot for 2-3 weeks and refer for displacement, angulation, rotation
  5. Solid Organ Transplant (surgery, failure)
    1. Immunosuppressants include Calcineurin (e.g. Tacrolimus), mTor (e.g. Sirolimus) and Purine (e.g. Azathioprine) inhibitors
    2. Immunosuppressants have numerous drug interactions (CYP3A4) with risk of toxicity and organ rejection
    3. Non-Estrogens (e.g. IUD, depo-Provera, Implanon) are preferred contraceptives post-transplant (fewer drug interactions)
    4. Opportunistic infections include CMV, EBV, HSV, VZV, fungus, pneumocystis, Tuberculosis
    5. Preventive care includes screening/management of CKD, DM, lipids, htn, Osteoporosis, Tobacco, cancer (esp. non-Melanoma skin)
    6. Infection prevention includes foodbourne illness prevention, Immunizations (flu, prevnax/Pneumovax), travel precautions
  6. Brain Tumor in Adults (neuro, hemeonc)
    1. High dose ionizing radiation is the only proven non-genetic risk factor for primary brain malignancy in adults
    2. Primary brain malignancies account for <2% of all malignancies in the U.S.
    3. Bifrontal tension-type Headache is most common presentation (followed by Seizure, cognitive change, focal weakness)
    4. Red flag signs include Cranial Nerve 6 palsy, focal weakness, Gait Abnormality
    5. Benign tumors (esp. meningioma) account for 50% of Brain Tumors and most malignancies are gliomas (astrocytoma, glioblastoma)
    6. Differential Diagnosis includes Multiple Sclerosis and infection (AIDS, Amebiasis, fungi, Cysticercosis, Sarcoidosis, Syphilis, tyberculosis)
  7. Acetaminophen Overdose (pharm, Analgesic, toxin)
    1. Acetaminophen level at 4 hours is the only reliable method to exclude toxicity (unless undetectable at >1 hour post-ingestion)
  8. Tramadol (pharm, Analgesic, Opioid)
    1. Tramadol is as weak as Tylenol 3, with the same schedule IV as Hydrocodone
    2. Addictive potential with risk of Overdose (deaths have occurred) and Serotonin Syndrome
  9. Gum Elastic Bougie (lung, airway, intubation)
    1. Under-rated intubation tool that deserves practice during routine intubations, preparing for the difficult airway
  10. Acute pulmonary edema (cv, chf)
    1. NIPPV (Bipap or CPAP) and Nitroglycerin are first-line interventions, followed by possible ACE Inhibitor
    2. IV Furosemide is only indicated in the subset of pulmonary edema patients who are volume overloaded
  11. Congestive Heart Failure Exacerbation Management (cv, chf, prevent)
    1. Up to 25% of patients are re-admitted in the first month and 33% rehospitalized or die within first 90 days
    2. Contact by phone or email within 2 days of hospital discharge (symptoms, weights, Medication Compliance)
    3. Clinic follow-up within 7 days and consider medication adjustment (ACE Inhibitor, Beta Blocker, Diuretic, Spironolactone)
  12. Synthetic Drugs of Abuse (psych, cd, toxin)
    1. Synthetic Marijuana (K2, Spice) is a THC analog with unpredictable effects, including acute Psychosis lasting up to months after even a single dose
    2. Synthetic Cathinones (bath salts) are stimulants with risk of Agitated Delirium, Rhabdomyolysis, cva and hyperthermia
    3. NBOMe (N-Bomb) is a synthetic Hallucinogen, with typical stimulant adverse effects (Agitated Delirium, Rhabdomyolysis, hyperthermia)
  13. Atrial Fibrillation Cardioversion (cv, ekg)
    1. Atrial thrombus may form within first 12 hours, however cardioversion still appears safe within first 48 hours
    2. Patients may be safely discharged if Heart Rate <110 bpm, BP >90/60 mmHg and mild symptoms
    3. Diltiazem IV is more effective in initial rate control, whereas Metoprolol is more effective for rate control on discharge
    4. Anticoagulation is recommended for first 3 weeks after cardioversion (due to stunned Myocardium)
  14. Atrial Fibrillation Anticoagulation (cv, ekg, coags)
    1. Restart Anticoagulation 7-14 days after Gastrointestinal Bleeding in CHADS2-VASc Score 2 or more
    2. Risk of stroke related mortality is 4x higher than mortality related to Gastrointestinal Bleeding
    3. Warfarin or Eliquis (Apixaban) have lower risk of Gastrointestinal Bleeding, whereas Pradaxa (Dabigatran) is higher risk
    4. Use Proton Pump Inhibitor for gastrointestinal prophylaxis
    5. Avoid combining Anticoagulant with Aspirin and Platelet ADP Receptor Antagonist (e.g. Plavix)
  15. Personal Protection Equipment (er, toxin)
    1. Donning and Doffing PPE includes putting on in order of gown, mask, goggles, gloves and removing in reverse order
    2. Standard Precautions include hand hygiene and blood and bodily fluid protection (gowns, gloves, masks, Eye Protection)
    3. Expanded Precautions include Contact Isolation (gown, gloves), Droplet Isolation (face mask) and Airborne Isolation (e.g. N95)
  16. Nexus Chest CT Decision Rule in Blunt Trauma (er, lung, Trauma)
    1. Criteria: Abnormal CXR, distracting injury, chest wall/sternal/Scapula/Thoracic Spine tenderness, rapid deceleration
    2. Absent criteria: Negative Likelihood Ratio of 0.04; CT chest not needed unless high pretest probability
  17. Droperidol (pharm, Sedation)
    1. Another study demonstrates safety with low risk of QT Prolongation (will FDA ever revise its warning?)
  18. Ketamine (pharm, pain)
    1. As effective as IV morphine in acute moderate to severe pain
  19. Incision and Drainage (derm, id, procedure)
    1. Wound irrigation during Incision and Drainage appears to be unnecessary
    2. How Incision and Drainage has changed: No packing (most cases), no irrigation, no antibiotics
  20. Pediatric Limp (ortho, peds, hip, sx)
    1. LIMPSS Mnemonic: Legg-Calve Perthes, Infection/Inflammation, Malignancy, Pain (Trauma), SCFE, Somewhere Else (Referred)
    2. Kocher's Criteria for septic hip: Fever >38.6 C, WBC>12k, ESR>40, child refuses to bear weight
    3. Hip Ultrasound demonstrating >2mm effusion requires aspiration to exclude septic hip
  21. Cervical Spine Injury (ortho, c-spine, Trauma)
    1. Cervical Collar is still standard of care, but no evidence of benefit and may cause harm
  22. Hemorrhage Management (er, surgery, Trauma, bleed)
    1. Direct pressure is first-line management
    2. Tourniquet for up to 1-2 hours may prevent Exsanguination and allows for definitive surgical management
  23. Cardiac Arrest (er, cv, ekg)
    1. Prehospital Resuscitation may be discontinued in Asystole >20 minutes and PEA Arrest >60 minutes (with ET-CO2 5)
    2. Bedside Ultrasound may identify improved chance of survival (e.g. obese with Pseudo-EMD)
    3. PEA with End-Tidal CO2 trending >20 and Heart Rate >40-60 are associated with improved chance of survival
  24. Glucometers (endo, dm)
    1. Glucometers cost $10 to over $100, but the test strips ($0.22 to $1.66 each) cost $84 to $600 per year for once daily testing
    2. Prescribe "Blood Glucose Meter" without specific brand and allow patient to select with pharmacist best option
    3. Meter features change constantly and some have large buttons, audio prompts or exportable data to mobile apps
    4. Test strip directions should include specific testing frequency (Medicare does not accept prn or as directed)
    5. Medicare allows for 100 test strips and 100 lancets every 30 days if on Insulin and every 90 days otherwise
  25. Hepatitis C Antiviral Regimen (gi, liver, id, virus)
    1. Hepatotoxicity with Ombitasvir, Paritaprevir/r (Technivie, Viekira Pak which also includes Dasabuvir) with Ribavirin
    2. Risk of fulminant liver failure (especially in pre-existing Cirrhosis) typically in first 1-4 weeks of treatment
      1. Repeat Liver Function Tests at 4 weeks after starting regimen (or earlier if needed)
      2. Consider stopping regimen if ALT >10 times normal (esp. if increased Bilirubin or INR)
  26. Selective Alpha-1a Antagonist (urology, pharm, Prostate, cv)
    1. Agents include Tamsulosin (Flomax), Alfuzosin (Uroxatral) and Silodosin (Rapaflo) used in BPH
    2. Despite selective nature, still cause Orthostatic Hypotension, fall risk, Head Trauma and Fractures
    3. Number needed to harm (NNH): 600 for fall-related hospitalizations, and 1600 for fall-related Fractures
    4. Welk (2015) BMJ 351:h5398 +PMID:26502947 [PubMed]
  27. Buprenorphine (pharm, pain, Opioid)
    1. Yet still more Opioids for Chronic Pain: Buprenorphine patch (Butrans) and buccal film (Belbuca)
    2. Are these really that much safer to warrant one more Opioid, or is this another free market, legal niche?
  28. Depression in Pregnancy (psych, ob, pharm)
    1. SSRIs have shown mixed or weak associations with Autism (as one of many contributing factors)
    2. Sertraline (Zoloft) is the preferred SSRI in pregnancy (although psychotherapy is preferred over medication)
  29. Cervical Cytology (gyn, Cervix, lab)
    1. Approach to ASC-US, ASC-H, LSIL, HSIL, Inadequate Pap Smear have changed dramatically in the last few years
    2. Extensive updates based on the 2014 ASCCP Guidelines
  30. Musculoskeletal Ultrasound (rad, Ultrasound, ortho, sports)
    1. Attended another GCUS Ultrasound course, but musculoskeletal Ultrasound is new to me and overwhelming
    2. Covered Shoulder Ultrasound, Elbow Ultrasound, Wrist Ultrasound, Hip Ultrasound, Knee Ultrasound, Ankle Ultrasound
    3. Still I am mystified with Bedside Ultrasound as pure magic (appropriately known as POCUS, should be prefixed with hocus)

VI. Updates: January 2016

  1. Fluoroquinolones (id, pharm)
    1. Increased risk of Peripheral Neuropathy, Tendinopathy and growing Antibiotic Resistance
    2. Pushed to third-line agent in Acute Sinusitis, Urinary Tract Infection, acute exacerbation Chronic Bronchitis
  2. Sinusitis (ent)
    1. Limit antibiotics to those with symptoms >10-14 days, fever or severe presentation (most cases are viral)
    2. High dose Amoxicillin in children and Augmentin in adults are first-line antibiotics
    3. In non-anaphylactic allergy to Penicillin, Cephalosporins are alternative agents
    4. Other agents in Penicillin Allergy include Clindamycin in children and doxycyline and Fluoroquinolones in adults
    5. Avoid Macrolides and TMP-SMZ due to high resistance rates
  3. Topical Analgesics (pharm, pain, rheum)
    1. Topical Analgesics include Topical NSAIDs and Lidoderm patch (as well as topical Capsaicin)
    2. Topical diclofenac (gel, solution, patch) may be effective, but is expensive, and should not be used with oral NSAIDs
    3. Exercise same precautions for topicals as for oral NSAIDs (avoid in cardiovascular and renal disease)
  4. Emergency Thoracotomy (ed, Trauma, cv)
    1. Indicated in refractory Massive Hemothorax or refractory penetrating Cardiac Tamponade
    2. Avoid if no signs of life in field, Asystole, loss of Vital Signs >15 minutes (Penetrating Trauma)
    3. Sequence: Intubate, IV/Fluids, left thoracotomy, control bleeding, restart heart, right Chest Tube
  5. Cardiogenic Shock (cv, chf, cad)
    1. Most commonly from large anterior Myocardial Infarction, right MI, papillary muscle rupture
    2. Involve early cardiology, cath lab, cardiothoracic surgery, intensivists to expedite disposition
    3. Treat Cardiogenic Shock with Dobutamine, Norepinephrine, Fluid Replacement to adequate LV volume
    4. Consider Endotracheal Intubation to reduce work of breathing
  6. Modified Valsalva for Supraventricular Tachycardia (cv, ekg)
    1. Postural modification significantly increases efficacy in PSVT cardioversion
    2. Valsalva is initially performed for 15 seconds sitting with head of bed at 30-45 degrees
    3. Patient repositioned immediately after Valsalva Maneuver to supine with legs raised
    4. Modified valsalva resulted in 43% of SVT patients converting at 1 minute, compared with 17% with standard valsalva
  7. Diaphragmatic Injury (er, lung)
    1. Penetrating Trauma (Gunshot Wound, Stab Wound) or blunt Trauma to anterior Abdomen (MVA, fall from height)
    2. Blunt Trauma is associated with 37% mortality due to multi-system Trauma (esp. CHI, large vessel rupture, Fractures)
    3. Penetrating Trauma is associated with a higher risk of occult Diaphragmatic Injury with delayed complications
    4. CT is insufficient to exclude Diaphragmatic Injury (False Negative Rate 18%)
    5. Laparoscopy and thoracoscopy are indicated in high suspicion cases (despite negative imaging)
  8. Tick Borne Illness (id, vector)
    1. Rocky Mountain Spotted Fever does not typically develop a rash until day 6 and may be fatal by day 8
    2. Alpha-gal Reaction results in hives or Anaphylaxis to red meat (after tick-mediated sensitization)
    3. Consider tick-borne illness even without Tick Bite history in Fever Without Source, focal neurologic deficits (e.g. Bell Palsy)
    4. Tick Borne Illness is a clinical diagnosis, not a lab diagnosis (except Peripheral Smear in Babesiosis and Anaplasmosis)
    5. Do not delay treatment of suspected Tick Borne Illness (esp. Rocky Mountain Spotted Fever)
    6. Doxycyline is the treatment of choice for Lyme Disease (except for children under age 8 years who are treated with amoxil)
    7. Doxycyline is the treatment of choice for Anaplasmosis, Ehrlichiosis, Rocky Mountain Spotted Fever (regardless of age)
    8. Babesiosis presents similarly to Malaria and is treated with Atovaquone and Azithromycin
  9. Congenital Heart Disease (cv, peds, chd)
    1. Up to 60% of Congenital Heart Disease has a delayed diagnosis (associated with worse outcomes)
    2. Nonstructural causes of cardiac emergencies in infants include arrhythmias and myocardial dysfunction
    3. Structural causes of cardiac emergencies are volume overload and pressure overload (obstruction)
    4. Volume Overload causes include VSD, ASD, PDA, TAPVR, Truncus, AV Canal
    5. Pressure overload causes are ductal dependent - Left-sided obstruction (e.g. coarct) or right-sided (e.g. pulmonic stenosis)
  10. Bariatric Surgery (endo, Obesity, surgery)
    1. Of 179,000 bariatric surgeries performed in 2013 in U.S., most were gastric sleeves (42%), followed by Roux-en-Y (34%)
    2. Excess body weight lost is 50% even at 7-10 years, remission of diabetes of 30% at 15 years, and 30-50% overall reduction in mortality
    3. However, patient assumes increased short-term complications including death, and longterm monitoring
  11. Acute Pelvic Pain (gyn, pain)
    1. Avoid tests that are low yield or do not alter management (C-RP, abdominal XRay)
    2. Abdominal Ultrasound has utility beyond the Uterus and Adnexa (e.g. Hydronephrosis, Appendicitis)
    3. Consider MRI Abdomen and Pelvis for pregnancy-related Pelvic Pain and suspected Appendicitis
  12. Asymptomatic Bacteriuria (urology, id)
    1. Very common, esp. older patients (15-20% in community and 40-50% in longterm care)
    2. Most Asymptomatic Bacteriuria resolves without treatment (including catheterized patients)
    3. Less than 3% of simple cystitis progresses to Pyelonephritis
    4. Urinalysis has poor Test Specificity for UTI in the absence of urinary tract symptoms
  13. Amiodarone Pulmonary Toxicity (cv, pharm, lung)
    1. Diffuse pneumonitis in 1-2% of patients on Amiodarone per year
    2. May present as refractory Pneumonia or CHF
    3. Early discontinuation and Prednisone for 4-12 months has best prognosis
    4. Obtain baseline Chest XRay and PFTs with DLCO when starting Amiodarone (in addition to TSH, transaminases)
  14. Juvenile Idiopathic Arthritis Exacerbation (rheum, peds)
    1. For exacerbations, obtain CBC, ESR and CRP
    2. Consider systemic infection (esp. if on Rituxamab or similar mab) or Septic Joint
    3. Be aware of Macrophage Activation Syndrome (cytokine storm) with risk of DIC, Acute Renal Failure, Pancytopenia
  15. Chemical Restraint alternatives (psych, er, violent)
    1. But be prepared with strong, large, burly security guards at the ready in case of dangerous agitation
    2. Provide a calm, quieter, comfortable setting with dimmed lights to help de-escalate agitation
    3. Offer food, drink, warm blanket , phone call and other comforts to those able to reason
    4. Offer Nicotine Replacement as needed and Benzodiazepines for Alcohol Withdrawal protocol or anxiety
    5. Express empathy and compassion
  16. Neuroimaging after First Seizure - Urgent Indications (neuro, Seizure)
    1. All patients under age 1 year
    2. Cognitive or Motor Developmental Delay
    3. Partial Seizure (focal Seizure), postictal neurologic deficit that persists, mental status changes persist
    4. Malignancy, Brain Tumor
    5. Prior Cerebrovascular Accident
    6. Coagulopathy, Sickle Cell Disease
    7. Head Trauma, Prior CNS surgery with shunt
  17. Umbilical Vein Catheter (nicu, er)
    1. Remains patent for the first week of life and may be used as a Central Line
    2. After preparing the umbilical stump and vein, advance 1-2 cm beyond free flow of blood (4-7 cm total)
  18. Abdominal Compartment Syndrome (gi, er, Trauma)
    1. Decreased abdominal perfusion pressure from rapidly expanding pressure within the abdominal cavity
    2. Critically ill patients with Abdominal Trauma or hemoperitoneum, massive fluid third spacing or Ascites
    3. Intraabdominal pressures (measured via Foley Catheter) >20-25 mmHg are consistent with Compartment Syndrome
    4. Definitive management with surgical decompression (NG and Foley Catheter may temporize)
  19. PIP Extensor Tendon Injury or Central Slip Extensor Tendon Injury (ortho, hand)
    1. Missed diagnosis risks secondary Boutonniere Deformity
    2. Elson Extensor Tendon Test evaluates PIP extension against resistance
  20. Home Naloxone Rescue Kits (pharm, Analgesic, adverse)
    1. Home rescue Naloxone may curb the >40 daily lethal Opioid Overdoses in the U.S.
    2. Naloxone autoinjector and intranasal spray are now commercially available intended for families to administer
    3. Home rescue kits may also be prepared for IM (Naloxone vials and syringes) or Nasal (prefilled syringes with atomizer)
  21. Hepatitis C Antiviral Regimen (gi, id, hepatitis)
    1. All genomes qualify for treatment (albeit with 3-4 drugs that cost over $100,000)
    2. Many adverse effects and drug interactions with treatment agents
  22. Asthma Exacerbation
    1. Dexamethasone 0.3 to 0.6 mg/kg/day PO/IV/IM up to 10-16 mg/dose for 1-2 days
    2. As effective as a 3 day Prednisolone course in preventing hospitalization and improving symptoms
  23. Somatic Symptom Disorder (psych, Somatization)
    1. Previously known as Somatoform Disorder or Somatization Disorder (the names have changed, but...)
    2. Now, nearly everyone will qualify for this diagnosis (the DSM-IV criteria were more stringent)
    3. Two scales can help make the diagnosis and assess severity (PHQ-15, SSS-8)
    4. Schedule monthly visits with primary provider to replace frequent phone calls and emergency visits
    5. Main provider role at the encounter: Empathic listening
  24. Impulse control behaviors and Dopamine Agonists (neuro, psych, pharm)
    1. Behaviors seen with Dopamine Agonists include Compulsive Gambling, hypersexuality, shopping, eating
    2. Now reported with Aripiprazole (Abilify), a partial Dopamine Agonist
  25. Tromethamine or THAM (renal, acidBase, er)
    1. Indicated in severe Metabolic Acidosis from Cardiac Arrest as an alternative to Sodium Bicarbonate
    2. THAM is a weak base that binds Hydrogen Ions and is excreted renally, unlike bicarbonate which is exhaled as CO2
    3. As with Sodium Bicarbonate, no evidence of outcome benefit in correction of Metabolic Acidosis
  26. Insulin Degludec (Tresiba)
    1. Yet another long acting Insulin; Lantus is generic and pricing should be on its way down

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