Infectious Disease Book

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Primaquine

Aka: Primaquine
  1. Indications
    1. Postexposure prevention for "relapsing" Malaria
    2. Eradication of Malaria liver involvement
  2. Contraindications
    1. G6PD Deficiency
  3. Directions
    1. May take with or without food
    2. Take with food to reduce gastric irritation
  4. Dosing: Treatment
    1. Adults
      1. Dose: 15 mg base (26.3 mg salt) PO qd for 14 days or
      2. Dose: 45 mg base (78.9 mg salt) PO weekly for 8 weeks
    2. Children
      1. 0.3 mg base (0.5 mg/kg salt) PO qd for 14 days or
      2. 0.9 mg/kg base (1.5 mg/kg salt) once Weekly x8 weeks

Primaquine (C0033126)

Definition (MSH) An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
Definition (CSP) aminoquinolone compound used as an antimalarial against the extraerythrocytic forms of Plasmodium vivax and P ovale and the gametocytes of P falciparum.
Definition (NCI) A synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts). (NCI04)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D011319
SnomedCT 429663004, 387194002, 324904009, 36391008
English Primaquine, primaquine, 1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)-, Primaquine (substance), Primaquine [Chemical/Ingredient], Primaquine (product), PRIMAQUINE
Swedish Primakin
Czech primachin
Spanish Primaquine, primaquina (sustancia), primaquina (producto), primaquina, Primaquina
Finnish Primakiini
Russian PRIMAKVIN, ПРИМАКВИН
Japanese プリマキン
Polish Primachina, Plazmochina
French Primaquine
German Primaquin
Italian Primachina
Portuguese Primaquina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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