Infectious Disease Book

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FluconazoleAka: Diflucan

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  1. Indications
    1. Onychomycosis
    2. Yeast Vaginitis (Single dose)
  2. Dosing
    1. Onychomycosis
      1. Adult Dose: 450 mg PO once per week
      2. Course
        1. Fingernail: 3-6 months
        2. Toenail: 6-12 months
    2. Yeast Vaginitis
      1. Adult dose: 150 mg PO for 1 dose
  3. Monitoring: Onychomycosis or Yeast Vaginitis
    1. No routine lab tests recommended
  4. Adverse effects (5% of patients)
    1. Nausea
    2. Headache
    3. Pruritus
    4. Liver Function Test abnormalities
  5. Drug interactions
    1. Absorption not affected by gastric pH
    2. Significant Sedation with Benzodiazepines
    3. Cimetidine decreases fluconazole levels
    4. Hydrochlorothiazide increases fluconazole levels
    5. Rifampin decreases fluconazole levels
    6. Oral Hypoglycemics (e.g. Sulfonylureas)
      1. Risk of Hypoglycemia
    7. Fluconazole increases theophylline levels
    8. Increased bleeding risk with Warfarin
  6. References
    1. Desai (1996) Am Fam Physician 54(4):1337
    2. Gupta (1999) J Am Acad Dermatol 41:237
    3. Friedlander (1999) Pediatr Infect Dis J 18(2):205
    4. Wildfeuer (1997) Mycoses 40:259

Fluconazole (C0016277)

Definition (MSH)Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
Definition (CSP)alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; an antifungal with potential efficacy for patients unable to take amphotericin B or who are immunologically compromised, as in AIDS.
Definition (NCI)A drug that treats infections caused by fungi.
Definition (PDQ)A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40842&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40842&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C500" NCI Thesaurus)
Definition (NCI)A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD015725
EnglishFCZ, Fluconazole, FLUCONAZOLE PREPARATION, Fluconazole product
Spanishfluconazol
Parent ConceptsAntifungal Agents (C0003308), Triazoles (C0040880), Triazole antifungal (C0360380), Triazole derivative (C1689939), Azole antifungal (C0360363)
SourcesCSP, LNC, MSH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Diflucan (C0699601)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD015725
EnglishDiflucan, Pfizer Brand of Fluconazole, Triflucan
SourcesCSP, MSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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