Infectious Disease Book

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Fluconazole

Aka: Fluconazole, Diflucan
  1. Indications
    1. Onychomycosis
    2. Yeast Vaginitis (Single dose)
  2. Dosing
    1. Onychomycosis
      1. Adult Dose: 450 mg PO once per week
      2. Course
        1. Fingernail: 3-6 months
        2. Toenail: 6-12 months
    2. Yeast Vaginitis
      1. Adult dose: 150 mg PO for 1 dose
  3. Monitoring: Onychomycosis or Yeast Vaginitis
    1. No routine lab tests recommended
  4. Adverse effects (5% of patients)
    1. Nausea
    2. Headache
    3. Pruritus
    4. Liver Function Test abnormalities
  5. Drug interactions
    1. Absorption not affected by gastric pH
    2. Significant Sedation with Benzodiazepines
    3. Cimetidine decreases Fluconazole levels
    4. Hydrochlorothiazide increases Fluconazole levels
    5. Rifampin decreases Fluconazole levels
    6. Oral Hypoglycemics (e.g. Sulfonylureas)
      1. Risk of Hypoglycemia
    7. Fluconazole increases theophylline levels
    8. Increased bleeding risk with Warfarin
  6. References
    1. Desai (1996) Am Fam Physician 54(4):1337-46
    2. Gupta (1999) J Am Acad Dermatol 41:237-49
    3. Friedlander (1999) Pediatr Infect Dis J 18(2):205-10
    4. Wildfeuer (1997) Mycoses 40:259-65

Diflucan (C0699601)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D015725
English diflucan, Diflucan, Pfizer Brand of Fluconazole, Triflucan
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Fluconazole (C0016277)

Definition (CHV) a kind of antifungal drug
Definition (MSH) Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
Definition (CSP) alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; an antifungal with potential efficacy for patients unable to take amphotericin B or who are immunologically compromised, as in AIDS.
Definition (NCI) A drug that treats infections caused by fungi.
Definition (NCI) A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.
Definition (PDQ) A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40842&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40842&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C500" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D015725
SnomedCT 31865003, 387174006
English 1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-, alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol, fluconazole, FLUCONAZOLE, Fluconazole, fluconazole (medication), Fluconazole [Chemical/Ingredient], Fluconazole product, Fluconazole (product), Fluconazole (substance), FCZ
Swedish Flukonazol
Czech flukonazol
Finnish Flukonatsoli
Russian FLUKONAZOL, ФЛУКОНАЗОЛ
Japanese フルコナゾール
Polish Flukonazol
Spanish fluconazol (producto), fluconazol (sustancia), fluconazol, Fluconazol
French Fluconazole
German Fluconazol
Italian Fluconazolo
Portuguese Fluconazol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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