http://www.fpnotebook.com/
FluconazoleAka: Diflucan
- Indications
- Onychomycosis
- Yeast Vaginitis (Single dose)
- Dosing
- Onychomycosis
- Adult Dose: 450 mg PO once per week
- Course
- Fingernail: 3-6 months
- Toenail: 6-12 months
- Yeast Vaginitis
- Adult dose: 150 mg PO for 1 dose
- Onychomycosis
- Monitoring: Onychomycosis or Yeast Vaginitis
- No routine lab tests recommended
- Adverse effects (5% of patients)
- Nausea
- Headache
- Pruritus
- Liver Function Test abnormalities
- Drug interactions
- Absorption not affected by gastric pH
- Significant Sedation with Benzodiazepines
- Cimetidine decreases fluconazole levels
- Hydrochlorothiazide increases fluconazole levels
- Rifampin decreases fluconazole levels
- Oral Hypoglycemics (e.g. Sulfonylureas)
- Risk of Hypoglycemia
- Fluconazole increases theophylline levels
- Increased bleeding risk with Warfarin
- References
Fluconazole (C0016277) | |
|---|---|
| Definition (MSH) | Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. |
| Definition (CSP) | alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; an antifungal with potential efficacy for patients unable to take amphotericin B or who are immunologically compromised, as in AIDS. |
| Definition (NCI) | A drug that treats infections caused by fungi. |
| Definition (PDQ) | A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40842&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40842&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C500" NCI Thesaurus) |
| Definition (NCI) | A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D015725 |
| English | FCZ, Fluconazole, FLUCONAZOLE PREPARATION, Fluconazole product |
| Spanish | fluconazol |
| Parent Concepts | Antifungal Agents (C0003308), Triazoles (C0040880), Triazole antifungal (C0360380), Triazole derivative (C1689939), Azole antifungal (C0360363) |
| Sources | CSP, LNC, MSH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Diflucan (C0699601) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D015725 |
| English | Diflucan, Pfizer Brand of Fluconazole, Triflucan |
| Sources | CSP, MSH, NCI, PDQ, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
