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Cytochrome P-450 2C19 Isoenzyme

Aka: Cytochrome P-450 2C19 Isoenzyme, CYP2C19
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  1. See Also
    1. CYP2C9
  2. Pharmacokinetics
    1. CYP2C19 deficiency in 20% of asians (poor metabolizers)
      1. Results in 5x higher blood concentration of Omeprazole and higher cure rates
    2. CYP2C19 ultrarapid metabolizers in 18% of Swedes and 18% of Ethiopians
      1. Results in 40% lower blood concentration of Omeprazole
    3. Reference
      1. Sim (2006) Clin Pharmacol Ther 79:103-13
  3. Interactions: Metabolized by CYP2C19 (Substrates)
    1. Neuropsychiatric drugs
      1. Clomipramine
      2. Imipramine
      3. Hexobarbital
      4. Mephobarbital
      5. Diazepam
      6. Phenobarbital
      7. Phenytoin
    2. Cardiopulmonary Drugs
      1. Propranolol (Inderal)
    3. Antibiotics
      1. Nelfinavir
    4. Miscellaneous
      1. Lansoprazole
      2. Pentamidine
      3. Felbamate
      4. Omeprazole (Prilosec)
  4. Interactions: Inhibitor of CYP2C19
    1. Neuropsychiatric drugs
      1. Fluvoxamine (Luvox)
    2. Antibiotics
      1. Isoniazid (INH)
      2. Ritonavir
    3. Miscellaneous
      1. Omeprazole (Prilosec)
      2. Cimetidine
  5. Interactions: Inducer of CYP2C19
    1. Neuropsychiatric Drugs
      1. Carbamazepine
      2. Phenytoin
    2. Antibiotics
      1. Rifampin

CYP2C19 protein, human (C0960580)

Definition (NCI) This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. (from LocusLink)
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH C045793
SnomedCT 423556000
English cytochrome P450 CYP2C(mp), cytochrome P450 2C19, human, Cytochrome p450 CYP2C19 enzyme (substance), Cytochrome p450 CYP2C19 enzyme, CYP2C19, cyp2c19, cytochrome P450 CYP2C19 (human), CYP2C(mp) protein, human, CYP2C19, human, CYPIIC19, human, P4502C19, human, cytochrome p-450 mephenytoin 4-hydroxylase, human, mephenytoin hydroxylase, human, propranolol 4-hydroxylase, human, (S)-mephenytoin-4'-hydroxylase, human, CYP2C19 protein, human, Flavoprotein-Linked Monooxygenase, CYPIIC17, CYPIIC19, P450-11A, P450-254C, Cytochrome P450 2C19, Cytochrome P450, Family 2, Subfamily C, Polypeptide 19, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19, EC 1.14.14.1, Mephenytoin 4'-Hydroxylase, Mephenytoin 4-Prime-Hydroxylase, Microsomal Monooxygenase, Xenobiotic Monooxygenase
Spanish enzima CYP2C19 del citocromo p450, enzima CYP2C19 del citocromo p450 (sustancia), CYP2C19
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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