Pharmacology Book

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Cytochrome P-450 2C9 Isoenzyme

Aka: Cytochrome P-450 2C9 Isoenzyme, CYP2C9
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  1. Precautions: CYP2C9 Deficiency related to Warfarin toxicity
    1. Higher risk for Warfarin toxicity and bleeding complications
    2. Start with lower doses
    3. Reaching a steady-state INR on Warfarin requires >3 months
    4. Voora (2005) Thromb Haemost 93:700-5
  2. Interactions: Metabolized by CYP2C9 (Substrates)
    1. Cardiopulmonary Drugs
      1. Carvedilol (Coreg)
      2. Tolbutamide
      3. Angiotensin Receptor Blockers (ARBs) affected
        1. Losartan (Cozaar)
        2. Irbesartan (Avapro)
      4. ARBs not affected by Cytochrome P450 System
        1. Valsartan
        2. Eprosartan
        3. Candesartan
    2. Miscellaneous
      1. Diclofenac
      2. Ibuprofen
      3. Piroxicam
      4. Celecoxib (Celebrex)
      5. Warfarin
      6. Glipizide
  3. Interactions: Inhibitor of CYP2C9
    1. Neuropsychiatric drugs
      1. Fluoxetine (Prozac)
    2. Cardiopulmonary Drugs
      1. Amiodarone
      2. Zafirlukast (Accolate)
      3. Fluvastatin (Lescol)
    3. Antibiotics
      1. Fluconazole (Diflucan)
      2. Ketoconazole
      3. Metronidazole (Flagyl)
      4. Ritonavir
      5. Trimethoprim-sulfamethoxazole (Septra)
  4. Interactions: Inducer of CYP2C9
    1. Neuropsychiatric drugs
      1. Carbamazepine
      2. Phenobarbital
      3. Phenytoin
    2. Antibiotics
      1. Rifampin

CYP2C9 protein, human (C0608437)

Definition (NCI) Induced by rifampin and expressed in liver by polymorphic human CYP2C9 Gene (CYP450 Family), 490-aa 56-kD Cytochrome P450 2C9 localizes to the endoplasmic reticulum membrane and oxidizes steroids, fatty acids, and xenobiotics in drug metabolism and in the synthesis of cholesterol, steroids and other lipids.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH C450260
English cyp2c9, S-mephenytoin 4-hydroxylase, human, cytochrome P-450 CYP2C10 (human), cytochrome P-450 CYP2C9, human, warfarin-7-hydroxylase, human, cytochrome P-450 CYP2C9 (human), CYP2C9 protein, human, Flavoprotein-Linked Monooxygenase, CYP2C9, P-450MP, P450 MP-4, P450 PB-1, Cytochrome P450 2C9, Cytochrome P450, Family 2, Subfamily C, Polypeptide 9, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 10, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9, EC 1.14.14.1, Mephenytoin 4-Hydroxylase, Microsomal Monooxygenase, S-Mephenytoin 4-Hydroxylase, Xenobiotic Monooxygenase, CYPIIC9, CYP2C10 protein, human, P-450MP protein, human, P450 MP-4 protein, human, P450 MP-8 protein, human
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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