Human Immunodeficiency Virus Book

http://www.fpnotebook.com/

Ritonavir

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  1. Mechanism
    1. Protease Inhibitor
  2. Efficacy
    1. Very effective with Zidovudine (AZT)
  3. Side effects
    1. Adverse effects are common
      1. Poorly tolerated
    2. Nausea or Vomiting
    3. Diarrhea
    4. Asthenia
    5. Paresthesias (Circumoral or peripheral)
    6. Triglycerides elevated
    7. Liver Function Tests
      1. Cholestatic enzymes elevated
      2. Hepatic transaminases elevated
  4. Drug interactions
    1. Rifampin
    2. Dexamethasone
    3. Anticonvulsants
  5. Dosing
    1. Ritonavir 600 mg bid ($668/mo)
    2. Bad taste (Mix with chocolate milk)

Ritonavir (C0292818)

Definition (MSH)An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV.
Definition (NCI)A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself.
Definition (CSP)HIV protease inhibitor that works by interfering with the replication cycle of HIV.
Definition (PDQ)A synthetic aromatic derivative with antiviral properties. Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases, thereby preventing the cleavage of Gag-Pol polyproteins and resulting in the production of noninfectious viral particles. This agent is more active against HIV-1. Because ritonavir targets the HIV replication cycle after translation and before assembly, it is active in chronically infected cells that generally are not affected by nucleoside reverse transcriptase inhibitors. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42665&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42665&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1609" NCI Thesaurus)
Definition (NCI)A synthetic aromatic derivative with antiviral properties. Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases, thereby preventing the cleavage of Gag-Pol polyproteins and resulting in the production of noninfectious viral particles. This agent is more active against HIV-1. Because ritonavir targets the HIV replication cycle after translation and before assembly, it is active in chronically infected cells that generally are not affected by nucleoside reverse transcriptase inhibitors. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD019438
EnglishRIT, Ritonavir, RITONAVIR PREPARATION, RTV
Spanishritonavir
Parent ConceptsAntiviral Agents (C0003451), Protease Inhibitor (C0033607), Thiazoles (C0039859), Anti-HIV Agents (C0376565), Retroviral protease inhibitor (C1268897), Drug allergen (C1320237), HIV Protease Inhibitors (C0162714)
SourcesCSP, LNC, MSH, MTH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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