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KetoconazoleAka: Nizoral
- See Also
- Imidazole
- Adverse Effects
- Nausea
- Headache
- Liver toxicity (Hepatotoxicity)
- Drug Interactions
- Serious cardiac arrhythmia with Hismanal or Seldane
- Lab monitoring
- Follow Liver Function Tests
- Dosing: Tinea Versicolor
- Dose
- Single dose: Ketoconazole 400 mg PO x1 dose
- Multiple dose: Ketoconazole 200 mg PO qd for 7 days
- Topical: Ketoconazole 2% cream applied qd for 2 weeks
- Technique
- Ketoconazole is excreted through eccrine Sweat Glands
- Patient should Exercise to sweating after dose
- Avoid showering for 16 to 24 hours after medication
- Directions
- Taking with food decreases gastric irritation
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| Definition (MSH) | Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. |
| Definition (CSP) | 1-acetyl-4-(2,4-dichlorophenyl-2-imidazolylmethyl- 1,3- dioxolanylmethoxyphenyl) piperazine; broad spectrum, oral antifungal. |
| Definition (NCI) | A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones. |
| Definition (PDQ) | A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C605" NCI Thesaurus) |
| Definition (NCI) | A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04) |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | KCZ, Ketoconazole, KETOCONAZOLE PREPARATION |
| Spanish | cetoconazol, ketoconazol |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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