Infectious Disease Book

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KetoconazoleAka: Nizoral

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  1. See Also
    1. Imidazole
  2. Adverse Effects
    1. Nausea
    2. Headache
    3. Liver toxicity (Hepatotoxicity)
  3. Drug Interactions
    1. Serious cardiac arrhythmia with Hismanal or Seldane
  4. Lab monitoring
    1. Follow Liver Function Tests
  5. Dosing: Tinea Versicolor
    1. Dose
      1. Single dose: Ketoconazole 400 mg PO x1 dose
      2. Multiple dose: Ketoconazole 200 mg PO qd for 7 days
      3. Topical: Ketoconazole 2% cream applied qd for 2 weeks
    2. Technique
      1. Ketoconazole is excreted through eccrine Sweat Glands
      2. Patient should Exercise to sweating after dose
      3. Avoid showering for 16 to 24 hours after medication
  6. Directions
    1. Taking with food decreases gastric irritation

Ketoconazole (C0022625)

Definition (MSH)Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
Definition (CSP)1-acetyl-4-(2,4-dichlorophenyl-2-imidazolylmethyl- 1,3- dioxolanylmethoxyphenyl) piperazine; broad spectrum, oral antifungal.
Definition (NCI)A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.
Definition (PDQ)A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C605" NCI Thesaurus)
Definition (NCI)A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishKCZ, Ketoconazole, KETOCONAZOLE PREPARATION
Spanishcetoconazol, ketoconazol
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Nizoral (C0699439)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishNizoral
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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