Infectious Disease Book

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Ketoconazole

Aka: Ketoconazole, Nizoral
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  1. See Also
    1. Imidazole
  2. Precautions
    1. Hepatotoxicity risk (FDA black box warning)
  3. Adverse Effects
    1. Nausea
    2. Headache
    3. Liver toxicity (Hepatotoxicity)
  4. Drug Interactions
    1. Serious cardiac arrhythmia with Hismanal or Seldane
  5. Lab monitoring
    1. Follow Liver Function Tests
  6. Dosing: Tinea Versicolor
    1. Dose
      1. Single dose: Ketoconazole 400 mg PO x1 dose
      2. Multiple dose: Ketoconazole 200 mg PO qd for 7 days
      3. Topical: Ketoconazole 2% cream applied qd for 2 weeks
    2. Technique
      1. Ketoconazole is excreted through eccrine Sweat Glands
      2. Patient should Exercise to sweating after dose
      3. Avoid showering for 16 to 24 hours after medication
  7. Directions
    1. Taking with food decreases gastric irritation
Medication Costs
Ketoconazole (on 2/9/2012 at DrugStore.com)
Ketoconazole 2% Shampoo 120ml Bottle #1 for $27.99 ($27.99/unit)
Ketoconazole 2% Foam 50gm Can #1 for $175.99 ($175.99/unit)
Ketoconazole 2% Foam 100gm Can #1 for $326.00 ($326.00/unit)
Ketoconazole 2% Cream 15gm Tube #1 for $19.99 ($19.99/unit)
Ketoconazole 2% Cream 30gm Tube #1 for $26.99 ($26.99/unit)
Ketoconazole 2% Cream 60gm Tube #1 for $35.99 ($35.99/unit)
Ketoconazole 200mg Tablets #14 for $30.99 ($2.21/unit)
Nizoral (on 2/9/2012 at DrugStore.com)
Nizoral 200mg Tablets #30 for $129.99 ($4.33/unit)
Nizoral 2% Shampoo 120ml Bottle #1 for $53.99 ($53.99/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ketoconazole (C0022625)

Definition (MSH) Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
Definition (NCI) A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)
Definition (CSP) 1-acetyl-4-(2,4-dichlorophenyl-2-imidazolylmethyl- 1,3- dioxolanylmethoxyphenyl) piperazine; broad spectrum, oral antifungal.
Definition (NCI) A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.
Definition (PDQ) A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C605" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D007654
SnomedCT 332902002, 324673001, 326240002, 387216007, 40232005
English Ketoconazole, Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-, Ketoconazole [gyn], Ketoconazole [infections], Ketoconazole [skin], Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, ketoconazole, Ketoconazole [gynaecological use], Ketoconazole [gynecological use], Ketoconazole [infections] (product), Ketoconazole [skin] (product), Ketoconazole [gynecological use] (product), ketoconazole (medication), KETOCONAZOLE, Ketoconazole [Chemical/Ingredient], Ketoconazole (product), Ketoconazole (substance), KCZ, Ketoconazole [gynecological use] (substance), Ketoconazole [infections] (substance), Ketoconazole [skin] (substance)
Swedish Ketokonazol
Spanish ketoconazol [infecciones], ketoconazol (piel), cetoconazol (uso dermatológico) (producto), ketoconazol [antiinfeccioso] (producto), ketoconazol [uso ginecológico], ketoconazol [uso ginecológico] (producto), ketoconazol [antiinfeccioso], cetoconazol [antiinfeccioso], ketoconazol (uso dermatológico) (producto), cetoconazol (uso dermatológico), ketoconazol (uso dermatológico), cetoconazol [uso ginecológico], cetoconazol (producto), cetoconazol (sustancia), cetoconazol, ketoconazol (piel) (producto), ketoconazol (producto), ketoconazol (sustancia), ketoconazol [infecciones] (producto), ketoconazol, Ketoconazol
Czech ketokonazol
Finnish Ketokonatsoli
Russian KETOKONAZOL, КЕТОКОНАЗОЛ
Japanese ケトコナゾール, ニゾラール, ニトラゼン, ケトパミン, プルナ
Croatian KETOKONAZOL
Polish Ketokonazol
French Kétoconazole
German Ketoconazol
Italian Ketoconazolo
Portuguese Ketoconazol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Nizoral (C0699439)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D007654
English Janssen Brand of Ketoconazole, Ketoconazole Janssen Brand, nizoral, Nizoral
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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