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CoccidioidomycosisAka: Coccidiomycosis, Coccidioides immitis
- Epidemiology
- Important opportunistic infection in southwestern US
- Pathophysiology
- Infection with fungus Coccidioides immitis
- Symptoms
- Chills, weight loss
- Productive cough
- Chest Pain
- Arthralgias
- Signs
- Fever
- Cervical adenopathy
- Skin lesions
- Resemble Erythema Nodosum
- Lung
- Pleural Effusion
- Friction rub
- Pulmonary rales
- Lab
- Sputum KOH
- Positive for fungal elements
- Blood complement-fixing antibodies
- Positive
- Sputum KOH
- Diagnosis
- Coccidioidomycosis serology: IgM
- IgM positive by third week in 90% of patients
- Becomes negative 3 months after infection
- Complement fixation of IgG
- Low sensitivity, but high Specificity
- Skin Testing (for epidemiologic studies)
- Coccidioidin skin test
- Spherulin skin test
- Coccidioidomycosis serology: IgM
- Differential Diagnosis in HIV patients
- PCP Pneumonia
- Affected Organs
- Lung most commonly affected (similar to Pneumocystis)
- Management
- Disseminated disease
- Amphotericin B
- Palliative Therapy
- Fluconazole 600-800 mg/day
- Itraconazole 400 mg/day
- Disseminated disease
Coccidioides immitis (C0009184) | |
|---|---|
| Definition (CSP) | mitosporic fungal species which causes coccidiodomycosis. |
| Definition (MSH) | The sole species of COCCIDIOIDES. It can cause an acute, benign respiratory infection as well as a fatal, chronic systemic disease. |
| Concepts | Fungus (T004) |
| MSH | D003045 |
| English | Coccidioides immitis, Malbranchea state of Coccidioides immitis |
| Parent Concepts | Mitosporic Ascomycota (C1050848), Coccidioides (C0009183), Anamorph state (C0521039) |
| Sources | CSP, LNC, MSH, NCBI, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
Coccidioidomycosis (C0009186) | |
|---|---|
| Definition (MSH) | Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN. |
| Definition (CSP) | infection with a fungus of the genus Coccidioides, species C. immitis; primary form is an acute, benign, self limited respiratory infection due to inhalation of spores and varying in severity; secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. |
| Concepts | Disease or Syndrome (T047) |
| ICD9 | 114, 114.9 |
| MSH | D003047 |
| English | Coccidioidomycoses, Coccidioidomycosis, Infection by Coccidioides immitis, Posadas-Wernicke disease |
| Spanish | coccidioidomicosis, enfermedad de Posadas - Wernicke, infeccion por Coccidioides immitis |
| Parent Concepts | Mycoses (C0026946), Coccidioidomycosis (C0009186), Infection by Deuteromycetes (C0276698), Infection by Ascomycetes (C0276697), Duplicate concept (C1274013) |
| Sources | COSTAR, CSP, DXP, ICD9CM, LCH, MSH, MTH, NDFRT, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
COCCIDIOMYCOSIS (C0262426) | |
|---|---|
| Concepts | Disease or Syndrome (T047) |
| English | COCCIDIOMYCOSIS |
| Sources | COSTAR Derived from the NIH UMLS (Unified Medical Language System) |