Pulmonology Book

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Rifampin

Aka: Rifampin
  1. Background
    1. Semisynthetic derivative of rifamycin
    2. Rifamycin produced by Streptomyces mediterranei
    3. Drug resistance emerges rapidly
      1. Must be used with other antituberculous drugs
  2. Indications
    1. Multi-drug Tuberculosis Treatment regimen
  3. Dosing
    1. Adult: 600 mg/day PO or IV
    2. Pediatric: 10-20 mg/kg/day (Max 600/day)
  4. Adverse Effects
    1. Nephritis or Acute Renal Failure
    2. Pruritus with or without Rash
    3. Thrombocytopenia and Hemolytic Anemia
    4. Influenza-like Syndrome
      1. Associated with infrequent dosing
    5. Body fluids become orange tinged
      1. Urine
      2. Sweat
      3. Tears (may discolor contact lenses)
  5. Adverse Effects: Hepatotoxicity - Risk Factors
    1. Slow acetylators
    2. Hepatitis C
    3. Hepatitis B
    4. Concurrent Hepatotoxin exposure
    5. Age over 50 years
    6. Pregnancy and postpartum (within 3 months)
    7. Malnutrition
  6. Drug Interactions: Increases other drug elimination
    1. Anticoagulants (Warfarin)
    2. Ketoconazole
    3. Chloramphenicol
    4. Methadone

Rifampin (C0035608)

Definition (CHV) a kind of antibiotics
Definition (CHV) a kind of antibiotics
Definition (NCI) A drug used in the treatment of infections caused by bacteria. It belongs to the family of drugs called antibiotics.
Definition (MSH) A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Concepts Organic Chemical (T109) , Antibiotic (T195)
MSH D012293
SnomedCT 387159009, 29175007
English Benemycin, Rifampicin, Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)-, rifampicin, rifampin, Rifampin, rifampin (medication), RIFAMPIN, Rifampin [Chemical/Ingredient], Rifampicin product, Rifampin (product), Rifampin (substance), RIF
Swedish Rifampin
Czech rifampin, rifampicin
Finnish Rifampisiini
Russian RIFAMPIN, RIFAMPITSIN, RIFADIN, РИФАДИН, РИФАМПИН, РИФАМПИЦИН
Japanese リマクタン, リファジン, リファンピン, アプテシン, リファンピシン
Italian Rifampicina, Rifampina
Polish Rifampicyna
Spanish rifampicina (producto), rifampicina (sustancia), rifampicina, rifampina, Rifampicina, Rifampin
French Rifampicine
German Rifampicin, Rifampin
Portuguese Rifampicina, Rifampina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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