II. Background

  1. Central to hepatic metabolism of medications
  2. Often responsible for drug-drug interactions

III. Cytochrome P-450 Isoenzymes

  1. Hepatic Isoenzymes
    1. CYP3As (40-60% hepatic P-450 isoenzymes)
    2. CYP2D6 (2-5% hepatic P-450 isoenzymes)
    3. CYP2As (<1% hepatic P-450 isoenzymes)
    4. CYP1A2
    5. CYP2Cs
  2. Other Isoenzymes
    1. CYP1A1
    2. CYP2Bs
    3. CYP2E1
    4. CYP4As

IV. Antihypertensives not affected by Cytochrome P450 system

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