Pharmacology Book

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Cytochrome P-450

Aka: Cytochrome P-450, CYP450
  1. Background
    1. Central to hepatic metabolism of medications
    2. Often responsible for drug-drug interactions
  2. Cytochrome P-450 Isoenzymes
    1. Hepatic Isoenzymes
      1. CYP3As (40-60% hepatic P-450 isoenzymes)
      2. CYP2D6 (2-5% hepatic P-450 isoenzymes)
      3. CYP2As (<1% hepatic P-450 isoenzymes)
      4. CYP1A2
      5. CYP2Cs
    2. Other Isoenzymes
      1. CYP1A1
      2. CYP2Bs
      3. CYP2E1
      4. CYP4As
  3. Antihypertensives not affected by Cytochrome P450 system
    1. Valsartan, Eprosartan, Candesartan
    2. Prazosin, Clonidine
    3. Hydrochlorothiazide, Furosemide
  4. References
    1. (1999) Med Lett Drugs Ther 41(1056): 61-2
    2. Ament (2000) Am Fam Physician 61(6): 1745-54
    3. Bhatia (1997) Am Fam Physician 55(5):1683-94
    4. Flockhart (2002) Arch Intern Med 162:405-12
    5. Johnson (1999) Postgrad Med 105(2):193-222

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