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Cytochrome P-450 2D6 Isoenzyme

Aka: Cytochrome P-450 2D6 Isoenzyme, CYP2D6
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  1. Background
    1. Accounts for 2-5% of hepatic P-450 isoenzymes
  2. Precautions: CYP2D6 Deficiency
    1. Populations with CYP2D6 deficiency (poor metabolizers)
      1. Occurs in 7% of white persons
      2. Occurs in 2-7% of white persons
    2. Consequences of CYP2D6 Deficiency
      1. No response to codeine (not metabolized to active form)
      2. Exaggerated physiologic response to substrate medications listed below
    3. References
      1. Ingelman-Sundberg (2005) Pharmacogenomics J 5:6-13
  3. Interactions: Metabolized by CYP2D6 (Substrates)
    1. Neuropsychiatric drugs
      1. Tricyclics
        1. Amitriptyline (Elavil)
        2. Desipramine (Norpramin)
        3. Imipramine
        4. Paroxetine (Paxil)
        5. Nortriptyline (Pamelor)
        6. Trimipramine (Surmontil)
      2. Antipsychotics
        1. Perphenazine (Trilafon)
        2. Risperidone (Risperdal)
        3. Haloperidol (Haldol)
        4. Thioridazine (Mellaril)
      3. Neurologic
        1. Donepezil (Aricept)
    2. Cardiopulmonary Drugs
      1. Beta Blockers
        1. Carvedilol (Coreg)
        2. Metoprolol (Lopressor)
        3. Propranolol (Inderal)
        4. Timolol
        5. Water soluble Beta-Blockers not hepatic metabolized
          1. May not be affected by CYP2D6 system
          2. Examples: Sotalol, Nadolol, Atenolol
      2. 1C Antiarrhythmics
        1. Encainide
        2. Flecainide
        3. Mexiletine
        4. Propafenone
    3. Analgesics
      1. Codeine
      2. Dextromethorphan
      3. Oxycodone
      4. Hydrocodone
      5. Tramadol (Ultram)
  4. Interactions: Inhibitor of CYP2D6
    1. Neuropsychiatric drugs
      1. Haloperidol (Haldol)
      2. Thioridazine (Mellaril)
      3. Fluoxetine (Prozac)
      4. Paroxetine (Paxil)
    2. Cardiopulmonary Drugs
      1. Amiodarone
      2. Quinidine
    3. Antibiotics
      1. Ritonavir
      2. Terbinafine (Lamisil)
    4. Miscellaneous
      1. Celecoxib (Celebrex)
      2. Cimetidine
      3. Diphenhydramine (Benadryl)
  5. Interactions: Inducer of CYP2D6
    1. Neuropsychiatric drugs
      1. Fluoxetine (Prozac)
      2. Paroxetine (Paxil)
    2. Cardiopulmonary Drugs
      1. Quinidine
      2. Amiodarone
    3. Antibiotics
      1. Ritonavir
    4. Miscellaneous
      1. Cimetidine

Cytochrome P-450 CYP2D6 (C0057223)

Definition (NCI) This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrhythmic drugs; and amitriptyline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. (from LocusLink)
Definition (MSH) A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D019389
SnomedCT 425292000
English CYP2D6, 2-Hydroxylase, Imipramine, 4-Hydroxylase, Debrisoquine, 4-Monooxygenase, Debrisoquine, CYP 2D6, CYP2D6, Cytochrome P-450, Cytochrome P 450 CYP2D6, Cytochrome P450 2D6, Debrisoquine 4 Hydroxylase, Debrisoquine 4 Monooxygenase, Debrisoquine 4-Hydroxylase, Debrisoquine 4-Monooxygenase, Debrisoquine Hydroxylase, Hydroxylase, Debrisoquine, Imipramine 2 Hydroxylase, Imipramine 2-Hydroxylase, Monooxygenase, Sparteine, P-450 CYP2D6, Cytochrome, P450 2D6, Cytochrome, Sparteine Monooxygenase, Cytochrome p450 CYP2D6 enzyme (substance), Cytochrome p450 CYP2D6 enzyme, CYTOCHROME P 450 CYP 002 D 006, CYP 002 D 006, DEBRISOQUINE HYDROXYLASE 04, Cytochrome P-450 CYP2D6 [Chemical/Ingredient], p450 2d6, cyp2d6, Cytochrome P-450 CYP2D6, Flavoprotein-Linked Monooxygenase, P450-2D6, P450-DB1, Cytochrome P450 Subfamily IID Polypeptide 6, Cytochrome P450, Subfamily IID-Like 1, Cytochrome P450, Subfamily IID, EC 1.14.14.1, Microsomal Monooxygenase, P450DB1, Xenobiotic Monooxygenase, CYPIID6
Swedish Cytokrom P-450 CYP2D6
Spanish enzima CYP2D6 de citocromo p450, enzima CYP2D6 de citocromo p450 (sustancia), CYP2D6, Citocromo P-450 CYP2D6, Debrisoquina 4-Hidroxilasa, Debrisoquina Hidroxilasa
Czech cytochrom P-450 CYP2D6
Finnish Sytokromi P-450 CYP2D6
Russian DEBRIZOKHIN-4-GIDROKSILAZA, DEBRIZOKHINGIDROKSILAZA, TSITOKHROM P-450 CYP2D6, ДЕБРИЗОХИН-4-ГИДРОКСИЛАЗА, ДЕБРИЗОХИНГИДРОКСИЛАЗА, ЦИТОХРОМ P-450 CYP2D6
Japanese イミプラン2-ヒドロキシラーゼ, シトクロムP-450CYP2D6, チトクロームP-450CYP2D6, デブリソキン4-ヒドロキシラーゼ, デブリソキンヒドロキシラーゼ
Italian CYP 2D6, Debrisochina 4-idrossilasi, Debrisochina idrossilasi, Sparteina monoossigenasi, Imipramina 2-idrossilasi, Citocromo P450 2D6, CYP2D6, Citocromo P-450 CYP2D6
German CYTOCHROM P 450 CYP 002 D 006, CYP 002 D 006, DEBRISOQUIN HYDROXYLASE 04, CYP2D6, Cytochrom P-450 CYP2D6, Debrisoquin-4-Hydroxylase, Debrisoquin-Hydroxylase
French CYP 2D6, Cytochrome P450 2D6, CYP2D6, Cytochrome P-450 CYP2D6, Débrisoquine 4-hydroxylase, Débrisoquine hydroxylase
Polish Cytochrom P-450 CYP2D6
Portuguese CYP2D6, Citocromo P-450 CYP2D6, Debrisoquina 4-Hidroxilase, Debrisoquina Hidroxilase
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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