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TramadolAka: Ultram

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  1. Mechanism
    1. Opiate Analgesic (Codeine analog)
    2. Weak mu-receptor binding
    3. Inhibits Norepinephrine and Serotonin reuptake
    4. Reported low abuse and addiction potential
  2. Efficacy
    1. Equivalent effect to Tylenol with codeine (Tylenol #3)
  3. Dosing
    1. Usual dose: 50-100 mg q4-6 hours
  4. Dosing: Maximum dose per day
    1. Healthy patient: 400 mg/day
    2. Over age 75 years: 300 mg/day
    3. Renal Insufficiency (Creatinine Clearance <30 ml/min)
      1. Reduce dosing frequency to every 12 hours
      2. Do not exceed 200 mg per day
  5. Disadvantages
    1. More expensive and lower efficacy than other Narcotics

Tramadol (C0040610)

Definition (MSH)A narcotic analgesic proposed for severe pain. It may be habituating.
Definition (NCI)A synthetic codeine analogue, Tramadol has central analgesic properties with effects similar to opioids, such as morphine and codeine, acting on specific opioid receptors. Used as a narcotic analgesic for severe pain, it can be addictive and weakly inhibits norepinephrine and serotonin reuptake. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD014147
EnglishTramadol, TRAMADOL PREPARATION, Tramadol Viatris Brand, Viatris Brand of Tramadol, Zamudol
Spanishtramadol
Parent ConceptsCyclohexanols (C0010570), Dimethylamines (C0012409), Analgesics (C0002771), Opioids (C0242402), Opioid Receptor Agonist (C1883695), Analgesics, Non-Narcotic (C0242937), Opioid Analgesics, Short-acting (C1579331)
SourcesLNC, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Ultram (C0724054)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD014147
EnglishUltram
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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