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AcetaminophenAka: Acetaminophen with codeine, Tylenol, Tylenol with codeine, Tylenol #3

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  1. Indications
    1. Pain
    2. Fever
      1. Temperature >102 degrees Fahrenheit
      2. Fever at bedtime
  2. Efficacy: Acetaminophen with Codeine
    1. See Narcotic Analgesics for efficacy studies
    2. Codeine adds side effects but no benefit to Tylenol
    3. Tylenol and NSAIDs are as effective as Tylenol #3
  3. Efficacy: Rheumatologic conditions
    1. Scheduled dosing much more effective than prn
    2. Tylenol 1000 mg qid is as effective as Tylenol #3
  4. Dosing: Children
    1. Dose: Acetaminophen
      1. Well hydrated child: 15 mg/kg every 4 to 6 hours
      2. Dehydration risk: 10 mg/kg every 4 to 6 hours
      3. Dosing by age
        1. Age >2 months (5 kg): 80 mg per dose
        2. Age >4 months (6.5 kg): 100 mg per dose
        3. Age >6 months (8 kg): 120 mg per dose
        4. Age >12 months (10 kg): 160 mg per dose
        5. Age >2 years (13 kg): 200 mg per dose
        6. Age >3 years (15 kg): 240 mg per dose
        7. Age >5 years (19 kg): 280 mg per dose
      4. Maximum: 90 mg/kg/day (to 4 grams per day)
    2. Dose: Acetaminophen with Codeine Elixir
      1. Components
        1. Acetaminophen (120 mg/5ml Elixir)
        2. Codeine (12 mg/5ml Elixir)
      2. Dosing
        1. Age 3 to 6 years: 5 ml/dose every 4 hours prn
        2. Age 7 to 12 years: 10 ml/dose every 4 hours prn
  5. Dosing: Adults
    1. Regular Dose: 650 mg PO every 4 to 6 hours prn
    2. Higher Dose (Osteoarthritis)
      1. Regular Strength Tablet (325 mg)
        1. Take 975 mg (3 tablets) PO every 6 hours
      2. Extra-Strength Tablet (500 mg)
        1. Take 1000 mg (2 tablets) PO every 6 hours
    3. Maximum: 4 grams per day
      1. Do not exceed 12 regular strength tablets (325 mg)
      2. Do not exceed 8 extra-strength tablets (500 mg)
  6. Pharmacokinetics
    1. Similar potency and time-effect curve to Aspirin
    2. Duration: 4 hours
  7. Preparations
    1. Chewable: 80 mg
    2. Elixir: 160 per 5 ml
    3. Dropper: 80 mg per 0.8 ml
    4. Suppository: 120 mg, 325 mg, 650 mg
    5. Tablet
      1. Regular strength: 325 mg
      2. Extra-Strength: 500 mg
  8. Adverse Effects: Hepatotoxicity
    1. See Acetaminophen Toxicity
  9. Precautions
    1. Dehydration predisposes to overdosage
    2. Never exceed maximum daily dosage (hepatotoxicity)
  10. References
    1. (2000) Med Lett Drugs Ther 42(1085):73
    2. (1996) Med Lett Drugs Ther 38:5
    3. Katzung (1989) Basic and Clinical Pharmacology

Acetaminophen (C0000970)

Definition (MSH)Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
Definition (CSP)analgesic antipyretic derivative of acetanilide; weak antiinflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
Definition (NCI)A drug that reduces pain and fever (but not inflammation). It belongs to the family of drugs called analgesics.
Definition (NCI)An acetanilide with analgesic and antipyretic activity. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, this agent probably acts by inhibiting prostaglandin synthesis in the central nervous system (CNS). Inhibition of prostaglandin synthesis in the CNS results in elevation of the pain threshold and lowering of the thermal set point in the hypothalamus.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD000082
English4-Hydroxyacetanilide, Acetamidophenol, Acetaminophen, ACETAMINOPHEN PREPARATION, Acetaminophen product, Acetominophen, ACMP, APAP, Hydroxyacetanilide, N-Acetyl-p-aminophenol, p-Acetamidophenol, p-Hydroxyacetanilide, Paracetamol, Paracetamol - chemical, Paracetamol product
Spanishacetaminofeno, paracetamol
Parent ConceptsAnilides (C0003035), Anti-Inflammatory Agents, Non-Steroidal (C0003211), Antipyretics (C0003419), phenylamide (C0597215), Acetanilides (C0000974), Analgesic AND antipyretic (C0280004), Analgesics, Non-Narcotic (C0242937), Duplicate concept (C1274013), Para-aminophenol derivative anti-inflammatory agent (C1690486), Acetaminophen or derivative (C1690527), Reason not stated concept (C1276325)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, MTHFDA, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Tylenol (C0699142)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD000082
EnglishTylenol
SourcesAOD, MSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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