II. Indications

III. Dosing: Standard

  1. Adult: 25-50 mg PO/IV/IM q6h
  2. Child: 5 mg/kg/day divided qid (12.5 mg/5 ml)

IV. Preparation: Diphenhydramine 1% (for Local Anesthesia)

  1. Dilute Diphenhydramine 5% in Normal Saline (1:4)
  2. Longer delay to onset of action than Lidocaine
  3. Shorter duration of action than Lidocaine

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Cost: Medications

diphenhydramine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
DIPHENHYDRAMINE 25 MG CAPSULE Generic OTC $0.03 each
DIPHENHYDRAMINE 50 MG CAPSULE Generic OTC $0.02 each
DIPHENHYDRAMINE 50 MG/ML SYRNG Generic $1.56 per ml
DIPHENHYDRAMINE 50 MG/ML VIAL Generic $0.69 per ml

Ontology: Diphenhydramine (C0012522)

Definition (CHV) a drug used to treat allergy symptoms
Definition (CHV) a drug used to treat allergy symptoms
Definition (NCI) A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.
Definition (NCI_NCI-GLOSS) A drug used to treat allergies and relieve cough and itching caused by insect bites, sunburn, and poison oak or ivy. It is also used to treat mild Parkinson disease, to prevent and treat motion sickness, to relieve cough and cold symptoms, and as a sleep aid. It is a type of antihistamine.
Definition (MSH) A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Definition (CSP) histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations; it has some undesired antimuscarinic and sedative effects.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004155
SnomedCT 256043008, 26458009, 372682005
LNC LP16116-3, MTHU019051, MTHU013946
English Benhydramin, Benzhydramine, Diphenhydramine, Diphenylhydramin, Diphenylhydramine, 2-Diphenylmethoxy-N,N-dimethylethylamine, diphenylhydramine, Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, diphenhydramines (medication), diphenhydramines, diphenhydramine (medication), Diphenhydramine [Chemical/Ingredient], DIPHENHYDRAMINE, diphenhydrAMINE, O-Benzhydryldimethylaminoethanol, 2-(Diphenylmethoxy)-N,N-dimethylethylamine, Rigidyl, Probedryl, diphenhydramine, Diphenhydramine product, Diphenhydramine (product), Diphenhydramine (substance), Diphenhydramine [dup] (substance)
Swedish Difenhydramin
Czech difenhydramin
Finnish Difenhydramiini
Russian DIFENGIDRAMIN, DIMEDROL, BENGIDRAMIN, DIFENILGIDRAMIN, БЕНГИДРАМИН, ДИМЕДРОЛ, ДИФЕНГИДРАМИН, ДИФЕНИЛГИДРАМИН
Japanese ベンヒドラミン, ジフェンヒドラミン, ジフェニルヒドラミン
Italian 2-difenilmetossi-N,N-dimetiletanamina, Difenilidramina
Polish Difenhydramina, Benzhydramina
Spanish difenhidramina (producto), difenhidramina (sustancia), difenhidramina, Benhidramina, Difenhidramina, Difenilhidramina
French Diphénhydramine
German Benhydramin, Diphenhydramin, Diphenylhydramin
Portuguese Benidramina, Difenidramina, Difenilidramina

Ontology: Benadryl (C0700899)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004155
English Benadryl