Otolaryngology Book

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DiphenhydramineAka: Benadryl

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  1. See Also
    1. Sedating Antihistamine
  2. Indications
    1. See Sedating Antihistamine
    2. Local Anesthesia for Lidocaine Allergy
  3. Dosing: Standard
    1. Adult: 25-50 mg PO/IV/IM q6h
    2. Child: 5 mg/kg/day divided qid (12.5 mg/5 ml)
  4. Preparation: Diphenhydramine 1% (for Local Anesthesia)
    1. Dilute Diphenhydramine 5% in Normal Saline (1:4)
    2. Longer delay to onset of action than Lidocaine
    3. Shorter duration of action than Lidocaine

Diphenhydramine (C0012522)

Definition (MSH)A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Definition (CSP)histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations; it has some undesired antimuscarinic and sedative effects.
Definition (NCI)A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishBenhydramin, Benzhydramine, Diphenhydramine, DIPHENHYDRAMINE PREPARATION, Diphenhydramine product, Diphenylhydramin, Diphenylhydramine
Spanishdifenhidramina
Parent ConceptsAntihistamines (C0003360), phenylalkoxyalkylamine (C0597213), Benzhydryl Compounds (C0005046), Ethylamines (C0015069), Antiemetics (C0003297), Histamine H1 Antagonists (C0019592), [AH200] ANTIHISTAMINES, ETHANOLAMINE (C0973466), [DE900] DERMATOLOGICALS, TOPICAL OTHER (C0993166), Antiparkinson Agents (C0003405), Antitussive Agents (C0003449), Sedating antihistamine (C0360183), Ethanolamine derivative antihistamine (C1305888), Duplicate concept (C1274013), Antiemetics (Non-5-HT3 Antagonists) (C1579363), Antiparkinson Agents, Other (C1579414)
SourcesCSP, LNC, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Benadryl (C0700899)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishBenadryl
SourcesMSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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