II. Indications

  1. Strong oral opioid Analgesic for moderate to severe pain

III. Precautions

  1. Risk of serious respiratory depression
  2. Among the most abused and diverted prescription medications

IV. Preparations: Immediate Release

  1. Oxycodone immediate release
    1. Adults (and over age 12 years) 5-10 mg every 4-6 hours as needed
    2. Child
      1. Moderate dose: 0.05 to 0.15 mg/kg/dose (up to 5 mg/dose) every 4-6 hours as needed
      2. High dose: 0.15 to 0.3 mg/kg/dose (up to 10 mg/dose) every 4-6 hours as needed
    3. Tabs: 5 mg (scored), 15, 30 mg
    4. Solution: 5 mg/ml
    5. Concentrate 20 mg/ml (dissolves sublingually)
  2. Acetaminophen and Oxycodone
    1. Percocet (Oxycodone 5 mg with Acetaminophen 325 mg)
      1. Dose: 1-2 orally every 6 hours as needed (adults or age over 12 years)
    2. Roxicet Solution (Oxycodone 5 mg and Acetaminophen 325 mg per 5 ml)
      1. Dose: Base on Oxycodone dose of 0.05 to 0.15 mg/kg/dose every 4-6 hours up to 5 mg/dose

V. Preparations: Controlled-Release (Extended Release)

  1. Oxycontin 10 mg every 12 hours
    1. Available in 10 mg, 15 mg, 20 mg, 30 mg, 40, 60 mg, 80 mg sustained release formulations
  2. Precautions
    1. Start with short acting Oxycodone and convert to long acting based on pattern of requirements
    2. Titrate slowly: 80 mg is very high dose and only for Opioid tolerant patients
    3. Do not break or chew sustained release product (risk of Overdose)
    4. Sustained release product is intended only for scheduled use (not prn)

VI. Adverse Effects

  1. Respiratory depression or arrest
    1. Reversal: Naloxone
  2. Nausea or Vomiting
  3. Constipation
  4. Sedation

VII. References

  1. Hamilton (2012) Tarascon Pharmacopeia, Jones and Bartlett, Burlington
  2. Robertson (2005) Harriet Lane Handbook, Mosby, Philadelphia p. 911

Images: Related links to external sites (from Google)

Cost: Medications

oxycodone (on 1/21/2015 at Medicaid.Gov Survey of pharmacy drug pricing)
OXYCODONE HCL 10 MG TABLET Generic $0.22 each
OXYCODONE HCL 100 MG/5 ML SOLN Generic $5.45 per ml
OXYCODONE HCL 15 MG TABLET Generic $0.26 each
OXYCODONE HCL 20 MG TABLET Generic $0.40 each
OXYCODONE HCL 30 MG TABLET Generic $0.44 each
OXYCODONE HCL 5 MG CAPSULE Generic $1.36 each
OXYCODONE HCL 5 MG TABLET Generic $0.15 each
OXYCODONE HCL 5 MG/5 ML SOLN Generic $0.22 per ml
OXYCODONE-ACETAMINOPHEN 10-325 Generic $0.78 each
OXYCODONE-ACETAMINOPHEN 10-325 MG TAB Generic $0.78 each
OXYCODONE-ACETAMINOPHEN 10-650 MG TAB Generic $0.36 each
OXYCODONE-ACETAMINOPHEN 2.5-325 MG TAB Generic $1.50 each
OXYCODONE-ACETAMINOPHEN 5-325 Generic $0.17 each
OXYCODONE-ACETAMINOPHEN 5-325 MG TAB Generic $0.17 each
OXYCODONE-ACETAMINOPHEN 5-500 MG CAP Generic $0.16 each
OXYCODONE-ACETAMINOPHEN 7.5-325 MG TAB Generic $0.73 each
OXYCODONE-ACETAMINOPHEN 7.5-500 MG TAB Generic $0.39 each
OXYCODONE-ASPIRIN 4.83-325 MG Generic $0.58 each
OXYCODONE-IBUPROFEN 5-400 TAB Generic $0.97 each
percocet (on 1/6/2015 at Medicaid.Gov Survey of pharmacy drug pricing)
PERCOCET 10-325 MG TABLET Generic $0.78 each
PERCOCET 5-325 MG TABLET Generic $0.17 each
PERCOCET 7.5-325 MG TABLET Generic $0.73 each
roxicodone (on 12/11/2014 at Medicaid.Gov Survey of pharmacy drug pricing)
ROXICODONE 15 MG TABLET Generic $0.26 each
ROXICODONE 30 MG TABLET Generic $0.44 each
endocet (on 1/21/2015 at Medicaid.Gov Survey of pharmacy drug pricing)
ENDOCET 10-325 MG TABLET Generic $0.78 each
ENDOCET 2.5-325 MG TABLET Generic $1.50 each
ENDOCET 5-325 TABLET Generic $0.17 each
ENDOCET 7.5-325 MG TABLET Generic $0.73 each
roxicet (on 9/17/2014 at Medicaid.Gov Survey of pharmacy drug pricing)
ROXICET 5-325 ORAL SOLUTION Generic $0.09 per ml
ROXICET 5-325 TABLET Generic $0.17 each