II. Indications

  1. Strong oral opioid Analgesic for moderate to severe pain

III. Precautions

  1. Risk of serious respiratory depression
  2. Among the most abused and diverted prescription medications

IV. Preparations: Immediate Release

  1. Oxycodone immediate release
    1. Adults (and over age 12 years) 5-10 mg every 4-6 hours as needed
    2. Child
      1. Moderate dose: 0.05 to 0.15 mg/kg/dose (up to 5 mg/dose) every 4-6 hours as needed
      2. High dose: 0.15 to 0.3 mg/kg/dose (up to 10 mg/dose) every 4-6 hours as needed
    3. Tabs: 5 mg (scored), 15, 30 mg
    4. Solution: 5 mg/ml
    5. Concentrate 20 mg/ml (dissolves sublingually)
  2. Acetaminophen and Oxycodone
    1. Percocet (Oxycodone 5 mg with Acetaminophen 325 mg)
      1. Dose: 1-2 orally every 6 hours as needed (adults or age over 12 years)
    2. Roxicet Solution (Oxycodone 5 mg and Acetaminophen 325 mg per 5 ml)
      1. Dose: Base on Oxycodone dose of 0.05 to 0.15 mg/kg/dose every 4-6 hours up to 5 mg/dose

V. Preparations: Controlled-Release (Extended Release)

  1. Oxycontin 10 mg every 12 hours
    1. Available in 10 mg, 15 mg, 20 mg, 30 mg, 40, 60 mg, 80 mg sustained release formulations
  2. Precautions
    1. Start with short acting Oxycodone and convert to long acting based on pattern of requirements
    2. Titrate slowly: 80 mg is very high dose and only for Opioid tolerant patients
    3. Do not break or chew sustained release product (risk of Overdose)
    4. Sustained release product is intended only for scheduled use (not prn)

VI. Adverse Effects

  1. Respiratory depression or arrest
    1. Reversal: Naloxone
  2. Nausea or Vomiting
  3. Constipation
  4. Sedation

VII. References

  1. Hamilton (2012) Tarascon Pharmacopeia, Jones and Bartlett, Burlington
  2. Robertson (2005) Harriet Lane Handbook, Mosby, Philadelphia p. 911

Images: Related links to external sites (from Google)

Cost: Medications

OxyCODONE HCl (on 2/9/2012 at DrugStore.com)
OxyCODONE HCl 15mg Tablets #20 for $20.78 ($1.04/unit)
OxyCODONE HCl 30mg Tablets #20 for $28.99 ($1.45/unit)
OxyCODONE HCl 5mg Tablets #20 for $22.76 ($1.14/unit)
OxyCODONE HCl 10mg Tablets #10 for $12.99 ($1.30/unit)
Oxycodone-Acetaminophen (on 2/9/2012 at DrugStore.com)
Oxycodone-Acetaminophen 5-325mg Tablets #20 for $11.99 ($0.60/unit)
Oxycodone-Acetaminophen 7.5-325mg Tablets #20 for $31.99 ($1.60/unit)
Oxycodone-Acetaminophen 10-325mg Tablets #20 for $40.66 ($2.03/unit)
Oxycodone-Acetaminophen 5-500mg Capsules #20 for $15.99 ($0.80/unit)
Oxycodone-Acetaminophen 7.5-500mg Tablets #20 for $25.99 ($1.30/unit)
Oxycodone-Acetaminophen 10-650mg Tablets #20 for $33.33 ($1.67/unit)
Oxycodone-Ibuprofen (on 2/9/2012 at DrugStore.com)
Oxycodone-Ibuprofen 5-400mg Tablets #20 for $33.33 ($1.67/unit)
Percocet (on 2/9/2012 at DrugStore.com)
Percocet 7.5-500mg Tablets #20 for $100.99 ($5.05/unit)
Percocet 10-650mg Tablets #20 for $130.99 ($6.55/unit)
Percocet 5-325mg Tablets #20 for $94.99 ($4.75/unit)
Percocet 2.5-325mg Tablets #30 for $90.99 ($3.03/unit)
Percocet 7.5-325mg Tablets #20 for $90.99 ($4.55/unit)
Percocet 10-325mg Tablets #20 for $127.99 ($6.40/unit)
Roxicodone (on 2/9/2012 at DrugStore.com)
Roxicodone 15mg Tablets #20 for $38.37 ($1.92/unit)
Roxicodone 30mg Tablets #20 for $73.36 ($3.67/unit)
OxyCONTIN (on 2/9/2012 at DrugStore.com)
OxyCONTIN 10mg 12 Hour Tablets #20 for $49.99 ($2.50/unit)
OxyCONTIN 15mg 12 Hour Tablets #20 for $72.99 ($3.65/unit)
OxyCONTIN 20mg 12 Hour Tablets #20 for $86.99 ($4.35/unit)
OxyCONTIN 30mg 12 Hour Tablets #20 for $125.99 ($6.30/unit)
OxyCONTIN 40mg 12 Hour Tablets #20 for $154.99 ($7.75/unit)
OxyCONTIN 60mg 12 Hour Tablets #20 for $214.99 ($10.75/unit)
OxyCONTIN 80mg 12 Hour Tablets #20 for $290.99 ($14.55/unit)
Endocet (on 2/9/2012 at DrugStore.com)
Endocet 5-325mg Tablets #30 for $17.99 ($0.60/unit)
Endocet 10-325mg Tablets #20 for $34.99 ($1.75/unit)
Endocet 10-650mg Tablets #20 for $35.99 ($1.80/unit)
Roxicet (on 2/9/2012 at DrugStore.com)
Roxicet 5-325mg/5ml Solution 500ml Bottle #1 for $46.19 ($46.19/unit)
Roxicet 5-325mg Tablets #20 for $12.99 ($0.65/unit)