II. Indications

  1. Fever
  2. Analgesia

III. Mechanism: NSAID - Propionic Acid

  1. Strong Analgesic action
  2. Moderate anti-inflammatory action (Dose >= 600 mg)

IV. Supplied

  1. Suspension: 100 mg/5ml
  2. Chewables: 50 mg, 100 mg
  3. Oral drops: 40 mg/ml
  4. Tablets: 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg

V. Dosing: Children older than age 6 months

  1. Dose: 5-10 mg/kg PO every 6 to 8 hours

VI. Dosing: Adult

  1. Dose: 400 to 800 mg orally three to four times daily
  2. Maximum: 3200 mg/day

VII. Contraindications

  1. Avoid in age under 6 months old

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Cost: Medications

IBUPROFEN (on 2/19/2015 at Target.com)
IBUPROFEN 100 MG/5 ML* Suspension #90 for $10.00 $0.11 each
IBUPROFEN 400 MG Tablet #90 for $10.00 $0.11 each
IBUPROFEN 600 MG Tablet #90 for $10.00 $0.11 each
IBUPROFEN 800 MG Tablet #90 for $10.00 $0.11 each
ibuprofen (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
IBUPROFEN 100 MG/5 ML SUSP Generic OTC $0.03 per ml
IBUPROFEN 200 MG CAPLET Generic OTC $0.03 each
IBUPROFEN 200 MG SOFTGEL Generic OTC $0.09 each
IBUPROFEN 200 MG TABLET Generic OTC $0.03 each
IBUPROFEN 400 MG TABLET Generic $0.05 each
IBUPROFEN 600 MG TABLET Generic $0.05 each
IBUPROFEN 800 MG TABLET Generic $0.06 each
IBUPROFEN COLD-SINUS CPLT Generic OTC $0.17 each
IBUPROFEN JR STR 100 MG CHEW Generic OTC $0.13 each
IBUPROFEN JR STR 100 MG TB CHW Generic OTC $0.13 each
IBUPROFEN PM CAPLET Generic OTC $0.12 each

Ontology: Ibuprofen (C0020740)

Definition (CHV) a chemical substance
Definition (CHV) a chemical substance
Definition (NCI) A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)
Definition (NCI_NCI-GLOSS) A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).
Definition (MSH) A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
Definition (CSP) nonsteroidal analgesic, antipyretic and anti-inflammatory agent that is a propionic acid derivative.
Definition (PDQ) A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C561" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D007052
SnomedCT 329955004, 329651005, 363606004, 322295006, 38268001, 387207008
LNC LP16165-0, MTHU004262, LA14347-1
English Ibuprofen, alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid, Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, Ibuprofen [cns analgesic], Ibuprofen [cns analgesic] [see j28..], Ibuprofen [musc-skel], Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-, p-Isobutylhydratropic Acid, ibuprofen, Ibuprofen [musculoskeletal use], Ibuprofen product, ibuprofen (OTC), ibuprofen (medication), Ibuprofen PMR, Ibuprofen [musc-skel use 2], Ibuprofen [musculoskeletal use 2], non-prescription ibuprofen, non-prescription ibuprofen (medication), IBUPROFEN, Ibuprofen [Chemical/Ingredient], ibuprofen products, Ibuprofen product (substance), Ibuprofen [cns analgesic] [see j28..] (product), Ibuprofen [musculoskeletal use] (product), Ibuprofen [musculoskeletal use 2] (product), (.+ -.)-p-Isobutylhydratropic acid, Propionic acid-ibuprofen, p-Isobutylhydratropic acid, Ibuprofen (product), Ibuprofen (substance), Ibuprofen [cns analgesic] [see j28..] (substance), Ibuprofen [musculoskeletal use 2] (substance), Ibuprofen [musculoskeletal use] (substance)
Swedish Ibuprofen
Czech ibuprofen
Finnish Ibuprofeeni
Russian IBUPROFEN, ИБУПРОФЕН
Japanese イブプロフェン
Polish Ibuprofen, Brufen
Norwegian Ibuprofen
Spanish ibuprofeno [uso musculoesquelético], ibuprofeno [uso musculoesquelético 2], ibuprofeno [analgésico de acción central] [véase j28..] (producto), ibuprofeno [analgésico de acción central] [véase j28..], ibuprofeno [uso musculoesquelético 2] (producto), ibuprofeno [uso musculoesquelético] (producto), ibuprofeno (producto), ibuprofeno (sustancia), ibuprofeno, ácido p-isobutilhidratrópico, Ibuprofeno
French Ibuprofène
German Ibuprofen
Italian Ibuprofene
Portuguese Ibuprofeno

Ontology: Advil (C0593507)

Definition (CHV) brand name of a pain killer drug
Definition (CHV) brand name of a pain killer drug
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Advil, advil [brand name], advil

Ontology: Motrin (C0699203)

Definition (CHV) brand name of ibuprofen
Definition (CHV) brand name of ibuprofen
Definition (CHV) brand name of ibuprofen
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D007052
English Motrin IB, motrin [brand name], motrin ib, motrin, Motrin

Ontology: Nuprin (C0699205)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D007052
English nuprin, Nuprin