II. Indications

  1. Fever
  2. Analgesia

III. Contraindications

  1. Avoid in age under 6 months old

IV. Mechanism

  1. NSAID in Propionic Acid class
  2. Strong Analgesic action
  3. Moderate anti-inflammatory action (Dose >= 600 mg)

V. Medications

  1. Suspension: 100 mg/5ml
  2. Chewables: 50 mg, 100 mg
  3. Oral drops: 40 mg/ml
  4. Tablets: 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg

VI. Dosing: Children older than age 6 months

  1. Dose: 5-10 mg/kg PO every 6 to 8 hours

VII. Dosing: Adult

  1. Dose: 400 to 800 mg orally three to four times daily
  2. Maximum: 3200 mg/day
  3. Ibuprofen Analgesic ceiling is 400 mg
    1. Doses 600 mg and 800 mg offer little additional Analgesic benefit above the 400 mg dose
    2. Motov (2019) Ann Emerg Med 74(4): 530-7 +PMID:31383385 [PubMed]

IX. Safety

  1. See NSAIDs regarding pregnancy safety
      1. [PubMed]

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Related Studies

Cost: Medications

ibuprofen (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
IBUPROFEN 100 MG/5 ML SUSP Generic $0.03 per ml
IBUPROFEN 200 MG CAPLET Generic OTC $0.03 each
IBUPROFEN 200 MG CAPSULE Generic OTC $0.09 each
IBUPROFEN 200 MG SOFTGEL Generic OTC $0.09 each
IBUPROFEN 200 MG TABLET Generic OTC $0.03 each
IBUPROFEN 400 MG TABLET Generic $0.05 each
IBUPROFEN 600 MG TABLET Generic $0.05 each
IBUPROFEN 800 MG TABLET Generic $0.07 each
IBUPROFEN COLD-SINUS CPLT Generic OTC $0.15 each
IBUPROFEN JR STR 100 MG TB CHW Generic OTC $0.14 each
IBUPROFEN PM CAPLET Generic OTC $0.13 each
IBUPROFEN-FAMOTIDIN 800-26.6 MG Generic $4.05 each