II. Background

  1. Cost: $5.30 per month

IV. Pharmacokinetics

  1. Serum Half Life: 21 hours
  2. Therapeutic plasma level: 110 to 250

V. Dosing: Insomnia

  1. Initial: 25 mg PO qhs
  2. Morning Hangover Effect: Taper to 10 mg PO qhs

VI. Dosing: Depression (listed for historical purposes only)

  1. Avoid for Depression given adverse effects
  2. SSRIs and other new Antidepressants are preferred
  3. Dose: 150-300 mg qhs

VII. Adverse effects

  1. See Tricyclic Antidepressants
  2. Significant adverse effects
    1. Sedation and morning grogginess
    2. Anticholinergic Symptoms
    3. Orthostatic Hypotension
    4. Cardiac arrhythmia
    5. Weight gain

VIII. Precautions

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Cost: Medications

AMITRIPTYLINE (on 2/19/2015 at Target.com)
AMITRIPTYLINE 10 MG Tablet #90 for $10.00 $0.11 each
amitriptyline (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
AMITRIPTYLINE HCL 10 MG TAB Generic $0.13 each
AMITRIPTYLINE HCL 100 MG TAB Generic $0.95 each
AMITRIPTYLINE HCL 150 MG TAB Generic $1.52 each
AMITRIPTYLINE HCL 25 MG TAB Generic $0.24 each
AMITRIPTYLINE HCL 50 MG TAB Generic $0.47 each
AMITRIPTYLINE HCL 75 MG TAB Generic $0.75 each

Ontology: Amitriptyline (C0002600)

Definition (NCI_NCI-GLOSS) A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic antidepressant.
Definition (NCI) A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.
Definition (MSH) Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Definition (CSP) tricyclic antidepressant with anticholinergic and sedative properties; it appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters; it also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D000639
SnomedCT 372726002, 40589005
LNC LP14983-8, MTHU004907
English Amitriptyline, amitriptyline, 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, Amitriptyline [Chemical/Ingredient], AMITRIPTYLINE, Amitriptyline (product), Amitriptyline (substance)
Swedish Amitriptylin
Czech amitriptylin
Finnish Amitriptyliini
Russian TRIPTIZOL, TEPERIN, AMITRIPTILIN, АМИТРИПТИЛИН, ТЕПЕРИН, ТРИПТИЗОЛ
Japanese アミトリプチリン, 塩酸アミトリプチリン
Croatian AMITRIPTILIN
Polish Amitryptylina
Spanish amitriptilina (producto), amitriptilina (sustancia), amitriptilina, Amitriptilina
French Amitriptyline
German Amitriptylin
Italian Amitriptilina
Portuguese Amitriptilina

Ontology: Elavil (C0087119)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D000639
English Cahill May Roberts Brand of Amitriptyline Embonate, Cahill May Roberts Brand of Amitriptyline Hydrochloride, DDSA Brand of Amitriptyline Hydrochloride, Merck Sharp & Dohme Brand of Amitriptyline Embonate, Merck Sharp & Dohme Brand of Amitriptyline Hydrochloride, Tryptanol, Zeneca Brand of Amitriptyline Hydrochloride, Elavil, Tryptizol