Mental Health Book

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AmitriptylineAka: Elavil

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  1. Background
    1. Cost: $5.30 per month
  2. Indications
    1. Fibromyalgia
    2. Insomnia
    3. Chronic Pain
  3. Pharmacokinetics
    1. Serum Half Life: 21 hours
    2. Therapeutic plasma level: 110 to 250
  4. Dosing: Insomnia
    1. Initial: 25 mg PO qhs
    2. Morning Hangover Effect: Taper to 10 mg PO qhs
  5. Dosing: Depression (listed for historical purposes only)
    1. Avoid for Depression given adverse effects
    2. SSRIs and other new Antidepressants are preferred
    3. Dose: 150-300 mg qhs
  6. Adverse effects
    1. See Tricyclic Antidepressants
    2. Significant adverse effects
      1. Sedation and morning grogginess
      2. Anticholinergic Symptoms
      3. Orthostatic Hypotension
      4. Cardiac arrhythmia
      5. Weight gain
  7. Precautions
    1. See Tricyclic Antidepressants

Amitriptyline (C0002600)

Definition (MSH)Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Definition (CSP)tricyclic antidepressant with anticholinergic and sedative properties; it appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters; it also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Definition (NCI)A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishAmitriptyline, AMITRIPTYLINE PREPARATION
Spanishamitriptilina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Elavil (C0087119)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishCahill May Roberts Brand of Amitriptyline Embonate, Cahill May Roberts Brand of Amitriptyline Hydrochloride, DDSA Brand of Amitriptyline Hydrochloride, Elavil, Merck Sharp & Dohme Brand of Amitriptyline Embonate, Merck Sharp & Dohme Brand of Amitriptyline Hydrochloride, Tryptanol, Tryptizol, Zeneca Brand of Amitriptyline Hydrochloride
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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