II. Mechanism

  1. Biogenic Amine Hypothesis
    1. Depression is associated with decreased monoamine (Serotonin, Norepinephrine and Dopamine) neurotransmission
    2. Antidepressants that increase synaptic Neurotransmitter concentrations appear to improve Major Depression
    3. Delayed Antidepressant effects may be related to postsynaptic monoamine receptor downregulation
    4. In contrast, mania occurs when there is excessive monoamine neurotransmission

VIII. Resources: Patient Education

  1. Information from your Family Doctor
    1. http://www.familydoctor.org/handouts/012.html

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