Mental Health Book

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Antidepressant Adverse Effects

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  1. See Also
    1. Antidepressant
    2. Serotonin Syndrome
    3. Antidepressant Withdrawal
  2. Adverse Effects: Anticholinergic Symptoms
    1. Most: Tricyclic Antidepressants (Tertiary amines)
    2. Least: SSRI, Bupropion, SARI, MAO inhibitors
  3. Adverse Effects: Weight gain (Histamine H1 receptor blockade)
    1. Most: Tricyclic Antidepressants, Remeron, Paxil
    2. Least: Bupropion, SSRI, Prozac
  4. Adverse Effects: Orthostatic Hypotension (alpha 1 receptor blockade)
    1. Most: Tricyclic Antidepressants (Tertiary amines)
    2. Least: Bupropion, SSRI
  5. Adverse Effects: Cardiac arrhythmia (Type 1A Antiarrhythmic effect)
    1. Most: Tricyclic Antidepressants (Tertiary amines)
    2. Least: Bupropion, SSRI
  6. Adverse Effects: Gastrointestinal effects (Serotonin reuptake blockade)
    1. Most adverse effects
      1. Nausea or Vomiting: Effexor
      2. Constipation: Paxil
      3. Diarrhea: Zoloft
    2. Minimal: Prozac, MAO inhibitors, Trazodone
    3. None: Tricyclic Antidepressants, Bupropion
  7. Adverse Effects: Sedation (Histamine H1 receptor blockade)
    1. Most: Tricyclic Antidepressants, Serzone, Trazodone
    2. Moderate: Remeron, Paxil, Nardil
    3. None: Bupropion, Effexor, Prozac
  8. Adverse Effects: Agitation or Insomnia
    1. Most: Bupropion, Effexor, Prozac, Paxil
    2. Least: Tricyclic Antidepressants, Effexor, Trazodone
  9. Adverse Effects: Increased Seizure risk (Lower Seizure threshold)
    1. Most: Bupropion, Anafranil, Tricyclic Antidepressant
    2. Least: SSRI, MAO inhibitor, SARI, Effexor
  10. Adverse Effects: Sexual dysfunction (Serotonin reuptake blockade)
    1. See Antidepressant Induced Sexual Dysfunction
    2. Most: SSRI, Tricyclic Antidepressants, MAO inhibitor
    3. Least: Bupropion, Nefazodone
  11. References
    1. Bhatia (1997) Am Fam Physician 55(5):1683
    2. Hansen (2005) Ann Intern Med 143:415

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