II. Efficacy

  1. May be less effective than Venlafaxine XR (Effexor XR)

III. Benefits (compared with Effetypxor XR)

  1. Easier to dose (only one dose) but as noted above, this is less effective than Effexor
  2. Touted to be better tolerated than Effexor, but studies do not bear this out
  3. Effexor XR will be generic in 2010 and is preferred

IV. Dosing

  1. Dose: 50 mg orally daily
  2. Tapering (do not cut tablet)
    1. Week 1: Skip one dose
    2. Week 2: Skip two doses
    3. Week 3: Skip three doses
    4. Week 4: Stop medication

V. Adverse Effects

  1. Antidepressant Withdrawal
  2. Empty ghost capsule in stool (typical finding)

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Cost: Medications

desvenlafaxine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
DESVENLAFAXINE ER 100 MG TAB Generic $3.87 each
DESVENLAFAXINE ER 50 MG TAB Generic $3.81 each
DESVENLAFAXINE SUC ER 100 MG Generic $1.62 each
DESVENLAFAXINE SUC ER 25 MG TB Generic $1.07 each
DESVENLAFAXINE SUC ER 50 MG TB Generic $1.48 each
pristiq (on 6/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
PRISTIQ ER 100 MG TABLET Generic $1.62 each
PRISTIQ ER 25 MG TABLET Generic $1.07 each
PRISTIQ ER 50 MG TABLET Generic $1.48 each