II. Definition

  1. Postpartum Hemorrhage (2014 definition)
    1. Blood loss >1000 ml OR
    2. Signs and symptoms of hypovolemia
    3. Previously diagnosed at blood loss >500 cc, need for pRBC transfusion or >10% drop in Hematocrit
  2. Primary Postpartum Hemorrhage (Early Postpartum Hemorrhage)
    1. Blood loss within 24 hours
  3. Secondary Postpartum Hemorrhage (Late Postpartum Hemorrhage)
    1. Blood loss after 24 hours and before 6 weeks
    2. Due to placental eschar slouphing, Retained Placenta

III. Epidemiology

  1. Incidence: 5% of all deliveries

IV. Risk Factors

  1. Prior history Postpartum Hemorrhage (RR 2-3)
  2. Prolonged third stage >18 minutes
  3. Proloned third stage >30 minutes (RR 6)

V. Causes: Mnemonic: 4T's

  1. Tone diminished
    1. Uterine Atony represents 70% Postpartum Hemorrhage causes
  2. Tissue
    1. Retained Placenta
    2. Placenta accreta
  3. Trauma
    1. Uterine Inversion
    2. Uterine Rupture
    3. Cervical Laceration
    4. Vaginal hematoma
  4. Thrombin
    1. Coagulopathy

VI. Pathophysiology: Uterine Atony

  1. Uterus fails to contract despite being empty
    1. Unable to control bleeding at placental site
  2. Predisposing Causes
    1. Excessive Uterine distension
      1. Twin Gestation
      2. Fetal Macrosomia
      3. Polyhydramnios
    2. Multiparity
      1. Fibrosis in uterine muscle
    3. Prolonged labor (uterine inertia)
    4. Prolonged Third Stage of Labor (>18 minutes)
    5. Labor augmented with Oxytocin
    6. Chorioamnionitis
    7. General Anesthesia
    8. Placenta Previa
      1. Lower segment does not contract
    9. Abruptio Placentae
      1. "Couvelaire" Uterus may not contract

VII. Risk Factors

  1. Grand Multipara
  2. Prolonged labor (especially prolonged third stage)
  3. Chorioamnionitis
  4. Multiple Gestation
  5. Magnesium Sulfate infusion
  6. Prolonged Pitocin infusion
  7. Episiotomy
  8. Fetal Macrosomia

VIII. Examination

  1. Inspect Vagina and Cervix for bleeding source

IX. Labs

  1. Complete Blood Count with platelets
  2. ProTime (PT)
  3. Partial Thromboplastin Time (PTT)
  4. Type and cross for 2-4 units of pRBC

X. Management: Active Management of the Third Stage of Labor

  1. Oxytocin (10 IU IM or 20 IU/L at 250 ml/h) administered on delivery of anterior Shoulder
    1. Reduces Incidence from 16.5% to 3.8% of deliveries
    2. See Third Stage of Labor
  2. Controlled cord traction
  3. Limit the third stage to <10 minutes
    1. Delayed placental delivery >10 min doubles bleed risk
  4. Early cord clamping and cutting does not appear to reduce Postpartum Hemorrhage risk
    1. Delayed cord clamping is now recommended for 1-3 minutes to reduce newborn Anemia risk

XI. Management: Resuscitation

  1. Indications
    1. Brisk bleeding
    2. Hypotension and Tachycardia
  2. Initial General Management
    1. Uterine massage
    2. Oxytocin (10 IU IM or 20 IU/L at 250 ml/h), and continue for first 24 hours
    3. Methergine 0.2 mg IM
    4. Large Bore (14-16 gauge) Intravenous Access (2 sites) and crystalloid bolus
    5. Close hemodynamic monitoring
    6. Supplemental Oxygen
    7. Patient in Trendelenburg
  3. Next measures for refractory bleeding
    1. Assess 4 Ts below
    2. Hemabate (15-methyl-prostaglandin F2 alpha)
      1. Dose: 0.25 to 1 mg IM or intromyometrium
      2. May repeat in 15 minutes
  4. Massive Hemorrhage Management
    1. Transfuse pRBC, platelets, Cryoprecipitate, factors as indicated
    2. Uterine packing and tamponade
      1. Compressive vaginal packing
      2. Foley Catheter balloon inflated within vagina
    3. Surgical interventions
      1. Vessel embolization
      2. Ligation of Uterine and Hypogastric arteries
      3. Hysterectomy

XII. Management: Four T's (see Above)

  1. Tone (Soft, boggy Uterus)
    1. Bimanual uterine massage
      1. Bimanual massage between vagina and uterine fundus
      2. Empty the Bladder!
    2. Uterotonic Medications
      1. Oxytocin 20 IU per Liter NS
        1. Infuse 250 cc/h (Max: 500 cc/10 min)
      2. Methergine 0.2 mg IM q2-4 hours
        1. Contraindicated in Hypertension
      3. 15-Methyl PGF2-alfa
        1. Hemabate 0.25 mg IM q15 min to maximum 2 mg or
        2. Carboprost
      4. Misoprostol (Cytotec, PGE1)
        1. Misoprostel 1000 mcg per Rectum or
        2. Misoprostel 400 mcg per Rectum after placenta delivery and 100 mcg at 4 hours and 8 hours
      5. Dinoprostone (PGE2)
        1. Caliskan (2002) Am J Obstet Gynecol 187:1038-45
  2. Trauma (Genital Laceration, Uterine Inversion)
    1. Inspect Vagina and Cervix for bleeding source
      1. Suture Lacerations if present
      2. Drain large hematomas (>3 cm)
      3. Remove retained clot within Cervix
    2. Evaluate Uterus
      1. Consider exploring Uterus
      2. Evaluate for Uterine Rupture
      3. Replace Uterine Inversion immediately and emergent Consultation (life threatening if not replaced)
  3. Tissue (Retained Placenta)
    1. Inspect placenta for missing segments
    2. Manually remove Retained Placenta or placenta accreta
    3. Consider curettage and prepare for possible Dilatation and Curettage or surgery
  4. Thrombin (Clotting disorder)
    1. Obtain labs as above
    2. Replace Coagulation Factors (and Blood Products as below)
      1. Fresh Frozen Plasma (FFP)
      2. Platelet Transfusion
      3. Factor VIIa

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Ontology: Postpartum Hemorrhage (C0032797)

Definition (NCI) Hemorrhage defined as a blood loss in excess of 500 mL after vaginal delivery or more than 1000 mL after a cesarean delivery.
Definition (MSH) Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
Concepts Pathologic Function (T046)
MSH D006473
ICD9 666
ICD10 O72
SnomedCT 47821001, 156239004, 156243000, 200033009
English Hemorrhage, Postpartum, Postpartum haemorrhage NOS, Postpartum hemorrhage NOS, Post-partum hemorrhage, postpartum hemorrhage (diagnosis), postpartum hemorrhage, Post-partum haemorrhage, Hemorrhage postpartum, Haemorrhage after delivery of foetus, Haemorrhage after delivery of fetus, Postpartum Hemorrhage [Disease/Finding], Bleeding;postpartum, hemorrhage postpartum, post-partum haemorrhage, postpartum bleed, Haemorrhage;postpartum, bleeding postpartum, post-partum bleeding, post-partum hemorrhage, Postpartum bleeding, Postpartum haemorrhage (disorder), Postpartum hemorrhage NOS (disorder), Haemorrhage postpartum, Postpartum haemorrhage NOS (disorder), Postpartum hemorrhage, Bleeding postpartum, PPH - Postpartum haemorrhage, PPH - Postpartum hemorrhage, Postpartum haemorrhage, Hemorrhage after delivery of fetus, Postpartum hemorrhage (disorder), Post-partum bleeding, hemorrhage; postpartum, postpartum; hemorrhage, Hemorrhage after delivery of fetus, NOS, Postpartum hemorrhage, NOS, Postpartum Hemorrhage, Hemorrhage;postpartum, postpartum bleeding, postpartum haemorrhage
Dutch bloeding postpartum, hemorragie postpartum, postpartum hemorragie NAO, postpartumhemorragie, Post-partum bloedverlies, bloeding; post partum, post partum; bloeding, postpartumbloeding, Bloeding post partum, Bloeding, post partum
French Hémorragie postpartum, Hémorragie post-partum, Hémorragie postpartum SAI, Saignement post-partum, Hémorragie du postpartum, Hémorragie du post-partum, Hémorragie de la délivrance
German Blutung postpartal, postpartale Blutung, postpartale Blutung NNB, Postpartales Bluten, Blutung, postpartale, Postpartale Blutung, Hämorrhagie, postpartale
Italian Emorragia postpartum NAS, Sanguinamento postpartum, Sanguinamento post partum, Emorragia postpartum
Portuguese Hemorragia pós-parto NE, Sangramento pós-parto, Hemorragia Puerperal, Hemorragia pós-parto, Hemorragia Pós-Parto
Spanish Sangrado postpartum, Hemorragia postparto NEOM, hemorragia después del parto del feto, Sangrado postparto, Hemorragia Posparto, Hemorragia Postparto, Postpartum hemorrhage NOS, hemorragia de postparto, SAI, hemorragia de postparto, SAI (trastorno), Postpartum haemorrhage NOS, Hemorragia Puerperal, hemorragia después del alumbramiento del feto, hemorragia posparto, hemorragia postparto (trastorno), hemorragia postparto, Hemorragia postparto
Japanese 分娩後出血NOS, ブンベンゴシュッケツNOS, ブンベンゴシュッケツ, 産褥出血, 分娩後出血, 出血-分娩後
Swedish Postpartumblödning
Finnish Synnytyksenjälkeinen verenvuoto
Czech Poporodní krvácení NOS, Krvácení po porodu, Poporodní krvácení, poporodní krvácení, poporodní hemoragie, postpartální hemoragie, hemoragie poporodní, postpartální krvácení
Korean 분만후 출혈
Polish Krwotok poporodowy, Krwawienie maciczne poporodowe
Hungarian Postpartum haemorrhagia, Postpartum vérzés, Haemorrhagia post partum, Postpartum vérzés k.m.n.
Norwegian Blødning etter fødsel, Post partum-hemoragi, Postpartumblødning, Post partum-blødning