Mental Health Book

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FluvoxamineAka: Luvox

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  1. Mechanism
    1. Selective Serotonin Reuptake Inhibitor (SSRI)
  2. Background
    1. Generic in 2001
  3. Indications
    1. Obsessive Compulsive Disorder (OCD)
  4. Dosing
    1. Adults
      1. Start: 25 mg (half of 50 mg tablet) qhs for 3 days
      2. Next: 50 mg PO qhs for 7 days
      3. Next: 50 mg PO bid OR 100 qhs
      4. Titrate to 150 - 250 mg daily divided bid
    2. Children (Age 8 years or older)
      1. Start: 25 mg PO qhs
      2. Maximum: 200 mg divided bid
  5. Pharmacokinetics
    1. Serum half life: 19 hours
  6. Adverse Effects
    1. Sedating
    2. Highest Nausea and Vomiting frequency
    3. Less anxiety (more Anxiolytic) than other SSRIs
    4. Less Sexual Dysfunction than Prozac, Zoloft, Paxil
      1. Sexual dysfunction in 10-15% of cases
      2. Similar to Celexa and Effexor
      3. See Antidepressant Induced Sexual Dysfunction
  7. Drug Interactions
    1. Inhibits Cytochrome P450-1A and P450-3A
      1. Avoid with Theophylline (risk of toxicity)
      2. Increases caffeine half life
    2. Raises Tricyclic Antidepressant levels
    3. Raises Warfarin (Coumadin) and associated INR levels
    4. Other interactions
      1. Seldane
      2. Hismanal
      3. Xanax
  8. Precautions
    1. Relatively safe
    2. Avoid in Hepatic and Renal insufficiency
    3. Avoid in pregnancy and Lactation
    4. No Overdose

Fluvoxamine (C0085228)

Definition (MSH)A selective serotonin reuptake inhibitor. It is effective in the treatment of depression, obsessive-compulsive disorders, anxiety, panic disorders, and alcohol amnestic disorders.
Definition (NCI)A 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and anxiolytic properties. Fluvoxamine, chemically unrelated to other selective serotonin reuptake inhibitors, selectively blocks serotonin reuptake by inhibiting the serotonin reuptake pump at the presynaptic neuronal membrane. This increases serotonin levels within the synaptic cleft, prolongs serotonergic transmission and decreased serotonin turnover, thereby leading to antidepressant, anxiolytic and antiobsessive-compulsive effects. Fluvoxamine shows no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors in vitro.
Definition (CSP)selective serotonin reuptake inhibitor effective in treatment of depression, obsessive compulsive disorders, anxiety, panic disorders, and alcohol amnestic disorders.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD016666
EnglishFluoxamine, Fluvoxamine, FLUVOXAMINE PREPARATION
Spanishfluvoxamina
Parent ConceptsAmines (C0002508), Antidepressive Agents (C0003289), Oximes (C0030020), Serotonin Uptake Inhibitors (C0162758), [CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS (C0973503), [CN609] ANTIDEPRESSANTS, OTHER (C0973506), Selective serotonin re-uptake inhibitor (C0360105), Drug allergen (C1320237)
SourcesAOD, CSP, LNC, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Luvox (C0086307)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD016666
EnglishArrow Brand of Fluvoxamine Maleate, Dumirox, Eurim Brand of Fluvoxamine Maleate, Faverin, Fevarin, Floxyfral, Luvox, Pharmacia Brand of Fluvoxamine Maleate, Solvay Brand of Fluvoxamine Maleate
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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