II. Class

  1. NSAID: COX2 Inhibitor
  2. Similar to Rofecoxib (Vioxx)
  3. Diaryl-substituted pyrazole

III. Advantages

  1. Less gastrointestinal adverse effects than other NSAIDs
    1. See NSAID Gastrointestinal Adverse Effects

IV. Metabolism

  1. Oral Bioavailability: 22 to 40%
  2. Half Life: 11 hours
  3. Liver metabolism by Cytochrome P450: CYP2C9
    1. Levels raised with Accolate, Diflucan, and Lescol
  4. Inhibits Cytochrome P450: CYP2D6
    1. Increases levels of Beta Blockers and psychotropics

V. Contraindications: Sulfonamide Allergy

  1. Consider alternative agent: Rofecoxib (Vioxx)

VI. Dosing

  1. Osteoarthritis: 200 mg PO qd (or 100 mg po bid)
  2. Rheumatoid Arthritis: 200 mg PO qd to bid
  3. Familial Adenoma Polyposis: 400 mg PO bid

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Related Studies

Cost: Medications

celecoxib (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CELECOXIB 100 MG CAPSULE Generic $0.10 each
CELECOXIB 200 MG CAPSULE Generic $0.11 each
CELECOXIB 400 MG CAPSULE Generic $0.49 each
CELECOXIB 50 MG CAPSULE Generic $0.13 each
celebrex (on 3/15/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CELEBREX 200 MG CAPSULE Generic $0.11 each