Pharmacology Book

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Celecoxib

Aka: Celecoxib, Celebrex
  1. Class
    1. NSAID: COX2 Inhibitor
    2. Similar to Rofecoxib (Vioxx)
    3. Diaryl-substituted pyrazole
  2. Advantages
    1. Less gastrointestinal adverse effects than other NSAIDs
      1. See NSAID Gastrointestinal Adverse Effects
  3. Metabolism
    1. Oral Bioavailability: 22 to 40%
    2. Half Life: 11 hours
    3. Liver metabolism by Cytochrome P450: CYP2C9
      1. Levels raised with Accolate, Diflucan, and Lescol
    4. Inhibits Cytochrome P450: CYP2D6
      1. Increases levels of Beta Blockers and psychotropics
  4. Contraindications: Sulfonamide allergy
    1. Consider alternative agent: Rofecoxib (Vioxx)
  5. Dosing
    1. Osteoarthritis: 200 mg PO qd (or 100 mg po bid)
    2. Rheumatoid Arthritis: 200 mg PO qd to bid
    3. Familial Adenoma Polyposis: 400 mg PO bid
  6. Adverse Effects
    1. See COX-2 Inhibitor for Nonfatal risk
    2. Abdominal Pain
    3. Diarrhea
    4. Dyspepsia
    5. Peptic Ulcer Disease risk (see COX2 Inhibitor)
    6. Does not increase Bleeding Time
  7. References
    1. Michalets (1998) Pharmacotherapy 18:84
    2. (1999) Med Lett Drugs Ther 41(1045): 11-14

Celebrex (C0719198)

Definition (CHV) a kind of arthritis drug
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C105934
English Celebrex, CeleBREX, celebrex, Pfizer brand of celecoxib
Sources
Derived from the NIH UMLS (Unified Medical Language System)


celecoxib (C0538927)

Definition (CHV) a drug used to treat pain and inflammation
Definition (NCI) A drug that reduces pain. Celecoxib belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is being studied in the prevention of cancer.
Definition (NCI) A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis.
Definition (PDQ) A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43023&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43023&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1728" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C105934
SnomedCT 330166009, 370187009, 116081000
English 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-, celecoxib, celecoxib (medication), Celecoxib (product), CELECOXIB, celecoxib [Chemical/Ingredient], Celecoxib (substance), Celecoxib product (product), Celecoxib product, Celecoxib
Spanish celecoxib (producto), producto con celecoxib (producto), celecoxib, producto con celecoxib, Celecoxib (sustancia), Celecoxib
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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