II. Class

  1. NSAID: COX2 Inhibitor
  2. Similar to Rofecoxib (Vioxx)
  3. Diaryl-substituted pyrazole

III. Advantages

  1. Less gastrointestinal adverse effects than other NSAIDs
    1. See NSAID Gastrointestinal Adverse Effects

IV. Metabolism

  1. Oral Bioavailability: 22 to 40%
  2. Half Life: 11 hours
  3. Liver metabolism by Cytochrome P450: CYP2C9
    1. Levels raised with Accolate, Diflucan, and Lescol
  4. Inhibits Cytochrome P450: CYP2D6
    1. Increases levels of Beta Blockers and psychotropics

V. Contraindications: Sulfonamide Allergy

  1. Consider alternative agent: Rofecoxib (Vioxx)

VI. Dosing

  1. Osteoarthritis: 200 mg PO qd (or 100 mg po bid)
  2. Rheumatoid Arthritis: 200 mg PO qd to bid
  3. Familial Adenoma Polyposis: 400 mg PO bid

VII. Adverse Effects

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Cost: Medications

celecoxib (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
CELECOXIB 100 MG CAPSULE Generic $0.70 each
CELECOXIB 200 MG CAPSULE Generic $0.87 each
CELECOXIB 400 MG CAPSULE Generic $2.07 each
CELECOXIB 50 MG CAPSULE Generic $0.47 each
celebrex (on 6/1/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
CELEBREX 100 MG CAPSULE Generic $0.70 each
CELEBREX 200 MG CAPSULE Generic $0.87 each
CELEBREX 400 MG CAPSULE Generic $2.07 each
CELEBREX 50 MG CAPSULE Generic $0.47 each

Ontology: celecoxib (C0538927)

Definition (CHV) a drug used to treat pain and inflammation
Definition (NCI) A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis.
Definition (NCI_NCI-GLOSS) A drug that reduces pain. Celecoxib belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is being studied in the prevention of cancer.
Definition (PDQ) A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43023&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43023&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1728" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C105934
SnomedCT 370187009, 330166009, 116081000
LNC LP28519-4, MTHU013163
English 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, celecoxib, celecoxib (medication), CELECOXIB, celecoxib [Chemical/Ingredient], Celecoxib (product), Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-, Celecoxib (substance), Celecoxib product (product), Celecoxib product, Celecoxib
Spanish celecoxib (producto), producto con celecoxib (producto), celecoxib, producto con celecoxib, Celecoxib (sustancia), Celecoxib

Ontology: Celebrex (C0719198)

Definition (CHV) a kind of arthritis drug
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C105934
English Celebrex, CeleBREX, celebrex, Pfizer brand of celecoxib