II. Mechanism

  1. Selective Beta Blocker

IV. Pharmacokinetics

  1. Onset of action in 5 minutes after intravenous dose
  2. Sustained response for 6-8 hours

V. Dosing: Oral

  1. Regular: 50 mg PO bid (Maximum 450 mg/day)
  2. Extended: 50-100 mg PO qd (Maximum 400 mg/day)

VI. Dosing: Intravenous

  1. Load: 2.5 to 5 mg IV over 2 to 5 minutes
  2. Repeated up to 3 doses (15 mg maximum)

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Cost: Medications

Metoprolol Tartrate (on 6/18/2017 at Walmart.com)
Metoprolol Tartrate 100mg #60 tablets for $4.00 $0.07 each
Metoprolol Tartrate 100mg #180 tablets for $10.00 $0.06 each
Metoprolol Tartrate 25mg #60 tablets for $4.00 $0.07 each
Metoprolol Tartrate 25mg #180 tablets for $10.00 $0.06 each
Metoprolol Tartrate 50mg #60 tablets for $4.00 $0.07 each
Metoprolol Tartrate 50mg #180 tablets for $10.00 $0.06 each
metoprolol (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
METOPROLOL SUCC ER 100 MG TAB Generic $0.39 each
METOPROLOL SUCC ER 200 MG TAB Generic $0.75 each
METOPROLOL SUCC ER 25 MG TAB Generic $0.22 each
METOPROLOL SUCC ER 50 MG TAB Generic $0.23 each
METOPROLOL TARTRATE 100 MG TAB Generic $0.04 each
METOPROLOL TARTRATE 25 MG TAB Generic $0.02 each
METOPROLOL TARTRATE 50 MG TAB Generic $0.02 each
METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB Generic $1.04 each
METOPROLOL-HYDROCHLOROTHIAZIDE 50-25 MG TAB Generic $0.81 each

Ontology: Metoprolol (C0025859)

Definition (MSH) A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Definition (NCI) A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008790
SnomedCT 372826007, 7092007
LNC LP16204-7, MTHU016612
English Metoprolol, 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, metoprolol (medication), Metoprolol [Chemical/Ingredient], METOPROLOL, metoprolol, Metoprolol (product), Metoprolol (substance)
Swedish Metoprolol
Czech metoprolol
Finnish Metoprololi
Russian N 93-26, METOPROLOL, МЕТОПРОЛОЛ, Н 93-26
Japanese 酒石酸メトプロロール, セレクナート, メデピン, メルコモン, ロプレソール, セロケン, ロプレソールSR, シオプトロール, セグミューラー, ココナリン, シプセロン, モジュメニー, セロケンL, メトプリック, メトラスター, カルスホン, メトプロロール
Polish Metoprolol
Spanish metoprolol (producto), metoprolol (sustancia), metoprolol, Metoprolol
French Métoprolol
German Metoprolol
Italian Metoprololo
Portuguese Metoprolol

Ontology: Lopressor (C0700776)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008790
English Lopresor, Novartis Brand of Metprolol Tartrate, lopresor, lopressor, Lopressor