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AripiprazoleAka: Abilify

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  1. Class
    1. Atypical Antipsychotic (Second Generation agent)
  2. Indications
    1. Schizophrenia
    2. Bipolar Disorder
    3. Major Depression (adjunct in refractory cases)
  3. Advantages
    1. Lower weight gain than other second generation Antipsychotic agents
    2. Lower diabetes risk than other second generation Antipsychotic agents
  4. Drug Interactions
    1. Increase Antipsychotic levels (toxicity risk): Monitor for Aripiprazole toxicity
      1. Clarithromycin
      2. Erythromycin
      3. Grapefruit juice
    2. Increase Antipsychotic levels (toxicity risk): Lower Aripiprazole dose to half
      1. Itraconazole
      2. Ketoconazole
      3. Quinidine
    3. Decrease Antipsychotic levels (lower efficacy)
      1. Barbiturates
      2. Carbamazepine
      3. Phenytoin
  5. Efficacy: Depression
    1. Depression remits in 25% of patients by 6 weeks (effects may be seen by 1 week)
  6. Adverse Effects
    1. Headache
    2. Restlessness or agitation
    3. Insomnia
    4. Anxiety
    5. Extrapyramidal Side Effects in up to 17% of patients
    6. Nausea
    7. Constipation
    8. Fatigue or Sedation
  7. Monitoring
    1. See Antipsychotic
  8. Dosing: Schizophrenia or Bipolar Disorder
    1. Starting dose: 10-15 mg once daily
    2. Maximum dose: 30 mg/day
  9. Dosing: Major Depression (in refractory and atypical cases)
    1. Starting dose: 2-5 mg/day
    2. Maximum dose: 15 mg/day (up to 30 mg/day has been used)

aripiprazole (C0299792)

Definition (NCI)A quinoline derivate and atypical anti-psychotic agent. Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors. This drug stabilizes dopamine and serotonin activity in the limbic and cortical system. Aripiprazole is used in managing symptoms of schizophrenia and of acute manic and mixed episodes associated with bipolar I disorders.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC094645
Englisharipiprazole, ARIPIPRAZOLE PREPARATION
Spanisharipiprazol
Parent ConceptsAntipsychotic Agents (C0040615), [CN709] ANTIPSYCHOTICS, OTHER (C0973508), Unclassified Ingredients (C1372954), Atypical antipsychotic (C1276996), Mood stabilizing drug (C1276998), Dihydrocarbostyril derivative antipsychotic (C1320173), Mood stabilizing agent (C1533054), Non-phenothiazines/ Atypicals (C1579416)
SourcesLNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Abilify (C1170019)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC094645
EnglishAbilify, Bristol-Myers Squibb brand of aripiprazole, Otsuka brand of aripiprazole
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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