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SotalolAka: Betapace

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  1. Indication
    1. Ventricular Arrhythmia
    2. Supraventricular Arrhythmia
      1. Atrial Fibrillation Cardioversion
        1. Time to Cardioversion: 3-6 hours
        2. Conversion Rate: 20-52%
        3. Chronic Efficacy: 50-60%
  2. Mechanism
    1. Class III Antiarrhythmic
      1. Prolongs action potential duration
      2. Increases cardiac tissue refractoriness
    2. Class II Antiarrhythmic
      1. Non-selective Beta Blocker
  3. Adverse Effects
    1. Bradycardia
    2. Hypotension
    3. Proarrhythmia (Torsades de pointes)
      1. Associated with doses over 320 mg per day
  4. Dosing: Oral
    1. Starting Dose: 80 mg PO bid
    2. Typical dosing: 80-160 mg PO bid
    3. Maximum: 640 mg per day

Sotalol (C0037707)

Definition (MSH)An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
Definition (NCI)An ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties. Sotalol is a nonselective beta-adrenergic receptor and potassium channel antagonist. In the heart, this agent inhibits chronotropic and inotropic effects thereby slowing the heart rate and decreasing myocardial contractility. This agent also reduces sinus rate, slows conduction in the atria and in the atrioventricular (AV) node and increases the functional refractory period of the AV node.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD013015
EnglishSotalol, SOTALOL PREPARATION
Spanishsotalol
Parent ConceptsEthanolamines (C0014983), Adrenergic beta-Antagonists (C0001645), Anti-Arrhythmia Agents (C0003195), [CV100] BETA-BLOCKERS/RELATED (C0973513), Non-selective beta-blocking agent (C0304515), Class III antiarrhythmic drug (C0360703)
SourcesAOD, CSP, LNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Betapace (C0728751)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishBetapace
SourcesNCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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