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Coronary Artery Disease

Congestive Heart Failure

Electrocardiogram

Examination

Hypertension

Inotrope

Hyperlipidemia

Pericardial Disorders

Hypotension

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Sotalol

Aka: Sotalol, Betapace
  1. Indication
    1. Ventricular Arrhythmia
    2. Supraventricular Arrhythmia
      1. Atrial Fibrillation Cardioversion
        1. Time to Cardioversion: 3-6 hours
        2. Conversion Rate: 20-52%
        3. Chronic Efficacy: 50-60%
  2. Mechanism
    1. Class III Antiarrhythmic
      1. Prolongs action potential duration
      2. Increases cardiac tissue refractoriness
    2. Class II Antiarrhythmic
      1. Non-selective Beta Blocker
  3. Adverse Effects
    1. Bradycardia
    2. Hypotension
    3. Proarrhythmia (Torsades de pointes)
      1. Associated with doses over 320 mg per day
  4. Dosing: Oral
    1. Starting Dose: 80 mg PO bid
    2. Typical dosing: 80-160 mg PO bid
    3. Maximum: 640 mg per day

Betapace (C0728751)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
English Betapace, betapace
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Sotalol (C0037707)

Definition (MSH) An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
Definition (NCI) An ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties. Sotalol is a nonselective beta-adrenergic receptor and potassium channel antagonist. In the heart, this agent inhibits chronotropic and inotropic effects thereby slowing the heart rate and decreasing myocardial contractility. This agent also reduces sinus rate, slows conduction in the atria and in the atrioventricular (AV) node and increases the functional refractory period of the AV node.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D013015
SnomedCT 372911006, 96301002
English Sotalol, Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-, sotalol, Sotalol [Chemical/Ingredient], Sotalol (product), Sotalol (substance), SOTALOL
Swedish Sotalol
Czech sotalol
Finnish Sotaloli
Russian SOTALOL, СОТАЛОЛ
Japanese ソタロール
Polish Sotalol
Spanish sotalol (producto), sotalol (sustancia), sotalol, Sotalol
French Sotalol
German Sotalol
Italian Sotalolo
Portuguese Sotalol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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