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AntiarrhythmicAka: Vaughn Williams Classification

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  1. Class I: Sodium Channel Blockade
    1. Class Ia: Lengthens action potential duration
      1. Quinidine
      2. Procainamide (Pronestyl)
      3. Disopyramide (Norpace)
      4. Imipramine (MAO inhibitor)
      5. Amiodarone (also Class II, III, IV)
    2. Class Ib: No effect on action potential
      1. Lidocaine (Xylocaine)
      2. Tocainide (Tonocard)
      3. Mexiletine (Mexitil)
      4. Phenytoin (Dilantin)
    3. Class Ic: Greater sodium current depression
      1. Flecainide (Tambocor)
      2. Encainide (Enkaid)
      3. Propafenone
  2. Class II: Beta Blocker
    1. Esmolol (Brevibloc)
    2. Sotalol (also Class III)
    3. Amiodarone (also Class Ia, III, IV)
  3. Class III: Prolong Refractory period via action potential
    1. Bretylium (Bretylol)
    2. Sotalol
    3. Amiodarone (also Class Ia, II, IV)
  4. Class IV: Calcium Channel Blocker
    1. Verapamil (Calan)
    2. Diltiazem (Cardizem)
    3. Amiodarone (also Class Ia, II, III)

Anti-Arrhythmia Agents (C0003195)

Definition (MSH)Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Definition (CSP)group of agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
Definition (NCI)Agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
Definition (CSP)agent causing or promoting cardiac arrhythmias.
ConceptsPharmacologic Substance (T121)
EnglishAnti Arrhythmia Agents, Anti Arrhythmia Drugs, Anti Arrhythmics, antiarrhythmia, Antiarrhythmia Agents, Antiarrhythmia Drugs, Antiarrhythmic agent, Antiarrhythmic drug, Antiarrhythmic Drugs, ANTIARRHYTHMICS, arrhythmic agent
Spanishagente antiarrítmico, agente antiarritmico, antiarrítmico, antiarrítmicos, antiarritmico, antiarritmicos, droga antiarrítmica, droga antiarritmica, fármaco antiarrítmico, farmaco antiarritmico
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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