II. Precautions

  1. Write for generic Nifedipine ER to allow pharmacist to substitute between multiple similar ER preparations
    1. (2016) Presc Lett 23(7): 39-40

IV. Indications

V. Contraindications

  1. Congestive Heart Failure
  2. Aortic Stenosis
  3. Avoid in Diabetes Mellitus (may increase Proteinuria)
  4. Concomitant use of Magnesium Sulfate
    1. Theoretically deactivates Calcium Gluconate antidote

VI. Dosing: Hypertension

  1. Nifedipine (Procardia) XL 30-60 mg PO qd (Maximum 120 qd)

VII. Dosing: Preterm Labor

  1. Load: Nifedipine 10 mg sublingual every 20 minutes for 3 doses
  2. Maintenance: Nifedipine10 to 20 mg PO every 4 to 8 hours

VIII. Adverse Effects

  1. Please see Calcium Channel Blockers
  2. Avoid short acting agents (increased coronary risk)
  3. Fetal effects
    1. Risk of Intrauterine Growth Retardation

IX. Monitoring: When used in Preterm Labor

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Cost: Medications

nifedipine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
NIFEDIPINE 10 MG CAPSULE Generic $0.65 each
NIFEDIPINE 20 MG CAPSULE Generic $1.65 each
NIFEDIPINE ER 30 MG TABLET Generic $0.32 each
NIFEDIPINE ER 60 MG TABLET Generic $0.46 each
NIFEDIPINE ER 90 MG TABLET Generic $0.50 each
procardia (on 6/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
PROCARDIA XL 30 MG TABLET Generic $0.24 each
PROCARDIA XL 60 MG TABLET Generic $0.30 each
afeditab (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
AFEDITAB CR 30 MG TABLET Generic $0.32 each
AFEDITAB CR 60 MG TABLET Generic $0.46 each

Ontology: Nifedipine (C0028066)

Definition (CHV) a drug used for hypertension
Definition (NCI) A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
Definition (MSH) A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Definition (CSP) calcium channel blocker used as a coronary vasodilator in the treatment of coronary insufficiency and angina.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D009543
SnomedCT 319352009, 387490003, 85272000
LNC LP17866-2, MTHU024723
English Nifedipine, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester, nifedipine, nifedipine (medication), Nifedipine [2], NIFEDIPINE, Nifedipine [Chemical/Ingredient], NIFEdipine, Nifedipine [2] (product), Nifedipine (product), Nifedipine (substance), Nifedipine [2] (substance)
Swedish Nifedipin
Czech nifedipin
Finnish Nifedipiini
Russian NIFEDIPIN, ADALAT, FENIGIDIN, KORINFAR, АДАЛАТ, КОРИНФАР, НИФЕДИПИН, ФЕНИГИДИН
Japanese ニフェジピン
Croatian NIFEDIPIN
Spanish nifedipino (producto), nifedipino (sustancia), nifedipina (producto), nifedipina, nifedipino, nifedipina (2), nifedipina (2) (producto), nifedipina (sustancia), Nifedipino
Polish Nifedypina
French Nifédipine
German Nifedipin
Italian Nifedipina
Portuguese Nifedipino

Ontology: Procardia (C0700861)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D009543
English Nifedipine Pfizer Brand, Pfizer Brand of Nifedipine, procardia, Procardia