Cardiovascular Medicine Book

Congestive Heart Failure

Coronary Artery Disease

Electrocardiogram

Examination

Hyperlipidemia

Hypertension

Miscellaneous

Pericardial Disorders

Obstetrics Chapter related topics

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NifedipineAka: Procardia, Dihydropyridine

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  1. See Also
    1. Dihydropyridine Calcium Channel Blocker
    2. Calcium Channel Blocker
  2. Pharmacology
    1. Prototype for Dihydropyridine Calcium Channel Blockers
      1. Norvasc
      2. Nimodipine
  3. Indications
    1. Hypertension
    2. Preterm Labor
  4. Contraindications
    1. Congestive Heart Failure
    2. Aortic Stenosis
    3. Avoid in Diabetes Mellitus (may increase Proteinuria)
    4. Concomitant use of Magnesium Sulfate
      1. Theoretically deactivates Calcium Gluconate antidote
  5. Dosing: Hypertension
    1. Nifedipine (Procardia) XL 30-60 mg PO qd (Maximum 120 qd)
  6. Dosing: Preterm Labor
    1. Load: Nifedipine 10 mg sublingual every 20 minutes for 3 doses
    2. Maintenance: Nifedipine10 to 20 mg PO every 4 to 8 hours
  7. Adverse Effects
    1. Please see Calcium Channel Blockers
    2. Avoid short acting agents (increased coronary risk)
    3. Fetal effects
      1. Risk of Intrauterine Growth Retardation
  8. Monitoring: When used in Preterm Labor
    1. Blood Pressure
    2. Edema
    3. Serial Fetal Ultrasounds

Dihydropyridines (C0012315)

Definition (MSH)Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.
ConceptsOrganic Chemical (T109)
EnglishDihydropyridine, Dihydropyridines
Spanishdihidropiridina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Nifedipine (C0028066)

Definition (MSH)A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Definition (CSP)calcium channel blocker used as a coronary vasodilator in the treatment of coronary insufficiency and angina.
Definition (NCI)A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishNifedipine, NIFEDIPINE PREPARATION
Spanishnifedipina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Procardia (C0700861)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishProcardia
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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