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Nifedipine

Aka: Nifedipine, Procardia
  1. See Also
    1. Dihydropyridine Calcium Channel Blocker
    2. Calcium Channel Blocker
    3. Calcium Channel Blocker Overdose
    4. Diltiazem
    5. Verapamil
    6. Mibefradil
  2. Pharmacology
    1. Prototype for Dihydropyridine Calcium Channel Blockers
      1. Norvasc
      2. Nimodipine
  3. Indications
    1. Hypertension
    2. Preterm Labor
  4. Contraindications
    1. Congestive Heart Failure
    2. Aortic Stenosis
    3. Avoid in Diabetes Mellitus (may increase Proteinuria)
    4. Concomitant use of Magnesium Sulfate
      1. Theoretically deactivates Calcium Gluconate antidote
  5. Dosing: Hypertension
    1. Nifedipine (Procardia) XL 30-60 mg PO qd (Maximum 120 qd)
  6. Dosing: Preterm Labor
    1. Load: Nifedipine 10 mg sublingual every 20 minutes for 3 doses
    2. Maintenance: Nifedipine10 to 20 mg PO every 4 to 8 hours
  7. Adverse Effects
    1. Please see Calcium Channel Blockers
    2. Avoid short acting agents (increased coronary risk)
    3. Fetal effects
      1. Risk of Intrauterine Growth Retardation
  8. Monitoring: When used in Preterm Labor
    1. Blood Pressure
    2. Edema
    3. Serial Fetal Ultrasounds

Procardia (C0700861)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D009543
English Nifedipine Pfizer Brand, Pfizer Brand of Nifedipine, procardia, Procardia
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Nifedipine (C0028066)

Definition (CHV) a drug used for hypertension
Definition (MSH) A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Definition (NCI) A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
Definition (CSP) calcium channel blocker used as a coronary vasodilator in the treatment of coronary insufficiency and angina.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D009543
SnomedCT 387490003, 85272000, 319352009
English Nifedipine, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester, nifedipine, nifedipine (medication), Nifedipine [2], NIFEDIPINE, Nifedipine [Chemical/Ingredient], NIFEdipine, Nifedipine (product), Nifedipine (substance), Nifedipine [2] (product), Nifedipine [2] (substance)
Swedish Nifedipin
Czech nifedipin
Finnish Nifedipiini
Russian NIFEDIPIN, ADALAT, FENIGIDIN, KORINFAR, АДАЛАТ, КОРИНФАР, НИФЕДИПИН, ФЕНИГИДИН
Japanese ニフェジピン
Croatian NIFEDIPIN
Spanish nifedipino (producto), nifedipino (sustancia), nifedipina (producto), nifedipina, nifedipino, nifedipina (2) (producto), nifedipina (2), nifedipina (sustancia), Nifedipino
Polish Nifedypina
French Nifédipine
German Nifedipin
Italian Nifedipina
Portuguese Nifedipino
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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