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Dihydropyridine Calcium Channel Blocker
Aka: Dihydropyridine Calcium Channel Blocker, Amlodipine, Norvasc, Nimodipine, Dihydropyridine- See Also
- Mechanism
- Dihydropyridine Calcium Channel Blockers
- Nifedipine (Procardia) is prototype for class
- Contraindications
- Avoid in Diabetes Mellitus (may increase Proteinuria)
- Preparation: Nifedipine
- See Nifedipine (Procardia)
- Preparation: Amlodipine (Norvasc)
- Dosing
- 2.5-5mg PO qd (MAX 10mg qd)
- Advantages
- Does not exacerbate Left Ventricular Dysfunction
- Dosing
- Preparation: Nimodipine
- Indications: Counter Cerebral Vessel spasm
- Early Subarachnoid Hemorrhage
- Early Cerebrovascular Accident (CVA)
- Indications: Counter Cerebral Vessel spasm
- Adverse Effects: Peripheral Edema (Norvasc)
- Occurs more commonly in women
- Occurs more commonly on Norvasc doses >5 mg
- Adding ACE Inhibitor to regimen decreases edema
| Medication Costs | ||
|---|---|---|
| AmLODIPine Besylate (on 2/9/2012 at DrugStore.com) | ||
| AmLODIPine Besylate 2.5mg Tablets | #90 for $19.99 | ($0.22/unit) |
| AmLODIPine Besylate 5mg Tablets | #90 for $22.99 | ($0.26/unit) |
| AmLODIPine Besylate 10mg Tablets | #90 for $23.99 | ($0.27/unit) |
| Amlodipine Besy-Benazepril HCl (on 2/9/2012 at DrugStore.com) | ||
| Amlodipine Besy-Benazepril HCl 5-10mg Capsules | #30 for $76.99 | ($2.57/unit) |
| Amlodipine Besy-Benazepril HCl 10-20mg Capsules | #30 for $89.99 | ($3.00/unit) |
| Amlodipine Besy-Benazepril HCl 5-40mg Capsules | #30 for $115.99 | ($3.87/unit) |
| Amlodipine Besy-Benazepril HCl 10-40mg Capsules | #30 for $115.99 | ($3.87/unit) |
| Amlodipine Besy-Benazepril HCl 5-20mg Capsules | #30 for $82.99 | ($2.77/unit) |
| Amlodipine Besy-Benazepril HCl 2.5-10mg Capsules | #30 for $69.99 | ($2.33/unit) |
| Amlodipine-Atorvastatin (on 2/9/2012 at DrugStore.com) | ||
| Amlodipine-Atorvastatin 5-10mg Tablets | #30 for $140.00 | ($4.67/unit) |
| Amlodipine-Atorvastatin 5-20mg Tablets | #30 for $169.99 | ($5.67/unit) |
| Amlodipine-Atorvastatin 10-10mg Tablets | #30 for $140.00 | ($4.67/unit) |
| Norvasc (on 2/9/2012 at DrugStore.com) | ||
| Norvasc 2.5mg Tablets | #30 for $80.99 | ($2.70/unit) |
| Norvasc 5mg Tablets | #30 for $79.99 | ($2.67/unit) |
| Norvasc 10mg Tablets | #30 for $107.99 | ($3.60/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Nimodipine (C0028094) |
|
|---|---|
| Definition (MSH) | A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure. |
| Definition (CSP) | 1,4 dihydropyridine; centrally acting calcium channel blocker used in the treatment of a wide range of disorders, including drug withdrawal, AIDS motor/cognitive disorder, and post cardiac surgery recovery. |
| Definition (NCI) | A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents. |
| Definition (NCI) | Belongs to a family of drugs called calcium channel blockers. It is being investigated for use with anticancer drugs to prevent or overcome drug resistance and improve response to chemotherapy. |
| Definition (PDQ) | A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41210&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41210&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C692" NCI Thesaurus) |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D009553 |
| SnomedCT | 387502003, 87285001 |
| English | Nimodipine, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester, nimodipine, NIMO, nimodipine (medication), NIMODIPINE, Nimodipine [Chemical/Ingredient], niMODipine, Nimodipine (product), Nimodipine (substance) |
| Swedish | Nimodipin |
| Czech | nimodipin |
| Finnish | Nimodipiini |
| Russian | NIMODIPIN, НИМОДИПИН |
| Japanese | ニモジピン |
| Spanish | nimodipino, nimodipina, nimodipino (producto), nimodipino (sustancia), nimodipina (producto), nimodipina (sustancia), Nimodipino |
| Polish | Nimodypina |
| French | Nimodipine |
| German | Nimodipin |
| Italian | Nimodipina |
| Portuguese | Nimodipino |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Norvasc (C0162712) |
|
|---|---|
| Definition (CHV) | brand name of a hypertension drug |
| Definition (CHV) | brand name of a hypertension drug |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D017311 |
| English | istin, norvasc [brand name], norvasc, Istin, Mack Brand of Amlodipine Besilate, Pfizer Brand of Amlodipine Besilate, Amlor, Norvasc |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Amlodipine (C0051696) |
|
|---|---|
| Definition (NCI) | A synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug response (MDR) activity through inhibition of the p-glycoprotein efflux pump. |
| Definition (MSH) | A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION. |
| Definition (CHV) | a drug used to treat high blood pressure and chest pain (angina) |
| Definition (CSP) | long-acting dihydropyridine calcium channel blocker; it is effective in the treatment of angina pectoris and hypertension. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D017311 |
| SnomedCT | 391763001, 108537001, 386864001 |
| English | Amlodipine, 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, amlodipine, Amlodipine - chemical (substance), AMLODIPINE, Amlodipine [Chemical/Ingredient], amLODIPine, Amlodipine (product), Amlodipine (substance), Amlodipine - chemical |
| Swedish | Amlodipin |
| Czech | amlodipin |
| Spanish | Amlodipine - chemical, amlodipino, amlodipino (sustancia), amlodipina, amlodipino (producto), amlodipina (producto), amlodipina (sustancia), Amlodipino |
| Finnish | Amlodipiini |
| Russian | AMLODIPIN, АМЛОДИПИН |
| Japanese | アムロジピン |
| Croatian | AMLODIPIN |
| Polish | Amlodypina |
| French | Amlodipine |
| German | Amlodipin |
| Italian | Amlodipina |
| Portuguese | Amlodipino |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Dihydropyridines (C0012315) |
|
|---|---|
| Definition (MSH) | Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D004095 |
| SnomedCT | 406769001 |
| English | Dihydropyridines, Dihydropyridine, Dihydropyridine (substance), Dihydropyridines [Chemical/Ingredient], dihydropyridines, dihydropyridine |
| Swedish | Dihydropyridiner |
| Czech | dihydropyridiny |
| Finnish | Dihydropyridiinit |
| Russian | DIGIDROPIRIDINY, ДИГИДРОПИРИДИНЫ |
| Japanese | ジヒドロピリジン |
| Spanish | bloqueante de los canales de calcio dihidropiridínico, bloqueante de los canales de calcio derivado de la dihidropiridina, bloqueante de los canales de calcio dihidropiridínico (sustancia), dihidropiridina (sustancia), dihidropiridina, Dihidropiridinas |
| Croatian | Not Translated[Dihydropyridines] |
| Polish | Dihydropirydyny pochodne |
| French | Dihydropyridines |
| German | Dihydropyridine |
| Italian | Diidropiridine |
| Portuguese | Diidropiridinas |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |