II. Definitiion

  1. Severe Hypertension: Blood Pressure >180/110 mmHg

IV. Precautions

  1. Avoid rapidly lowering Blood Pressure in asymptomatic patients with Severe Hypertension
    1. Severe Hypertension typically increases over weeks to months (as opposed to abruptly)
    2. Abrupt Blood Pressure lowering (e.g. Clonidine, Captopril, Nifedipine) is not recommended in asymptomatic patients
    3. Emergency care is not required for asymptomatic Severe Hypertension
      1. (2013) Ann Emerg Med 62:59-68 [PubMed]
  2. Hypoperfusion may occur with acute Blood Pressure lowering >20-25%
    1. Risk of cerebral ischemia
    2. In asymptomatic patients, avoid intravenous or excessive antihypertensive dosing
    3. Gradual Blood Pressure lowering of Severe Asymptomatic Hypertension over days to weeks is preferred
  3. Assess for sudden Hypertension Causes
    1. Consider non-compliance with antihypertensive medications
    2. See Secondary Hypertension Causes
    3. See Resistant Hypertension
  4. Avoid delaying management of Severe Hypertension in patients on Anticoagulation, Antiplatelet Therapy
    1. Control Hypertension early in those on Anticoagulation, Antiplatelet Therapy to prevent Hemorrhagic CVA

V. History

  1. See Hypertension Evaluation History
    1. Includes predisposing factors and Secondary Hypertension risks
  2. Hypertension History
    1. Onset and treatment history
    2. Medication Compliance
  3. Past Medical History
    1. Coronary Artery Disease
    2. Peripheral Vascular Disease
    3. Congestive Heart Failure
    4. Cerebrovascular Disease
    5. Chronic Kidney Disease
    6. Diabetes Mellitus
    7. Obstructive Sleep Apnea
    8. Current pregnancy or postpartum
      1. Consider Preeclampsia if between 20 weeks gestation and 6 weeks postpartum
  4. Acute Contributing Factors
    1. See Medication Causes of Hypertension
    2. Stimulant use (e.g. Cocaine)
    3. Abrupt cessation of drug or medication
      1. Alcohol Withdrawal
      2. Antihypertensive Withdrawal
    4. Newly added medication (esp. psychiatric medications)
      1. Serotonin Syndrome (esp. SSRI)
      2. Neuroleptic Malignant Syndrome (esp. Antipsychotics)
      3. Anticholinergic Syndrome

VI. Symptoms: End organ dysfunction related to Hypertension

  1. Red flag findings suggestive or target organ injury (Hypertensive Emergency or urgency)
    1. Contrast with the mild symptoms of Severe Asymptomatic Hypertension
  2. Cardiopulmonary Symptoms
    1. Chest Pain
    2. Shortness of Breath
    3. Orthopnea
    4. Syncope
    5. Edema
    6. Claudication (or cold distal extremities, weak distal pulses)
  3. Neurologic Symptoms
    1. Severe Headache
    2. Confusion or other Altered Level of Consciousness
    3. Vision Changes
    4. Extremity weakness
    5. Cranial Nerve deficit
    6. Incoordination
    7. Seizure
  4. Renal Symptoms
    1. Oliguria or Anuria

VII. Exam

  1. See Hypertension Evaluation Exam
  2. Cardiovascular Exam
    1. Arrhythmia
    2. Jugular Venous Distention
    3. Lower Extremity Pitting Edema
    4. Absent or diminished peripheral pulses (esp. Asymmetric Pulses)
    5. Abdominal bruit or pulsatile mass
  3. Respiratory Exam
    1. Hypoxia
    2. Rales
    3. Tachypnea
  4. Ophthalmologic Exam
    1. Retinal Hemorrhage
    2. Papilledema
  5. Neurologic Exam
    1. Altered Level of Consciousness
    2. Focal neurologic deficits

VIII. Signs: End organ dysfunction related to Hypertension

  1. Cardiac dysfunction
    1. Evaluate symptomatic patients (e.g. Angina, Dyspnea, Orthopnea, edema)
    2. Asymptomatic patients with Severe Hypertension are unlikely to benefit from Electrocardiogram or Chest XRay
    3. Karras (2008) Ann Emerg Med 51(3): 231-9 [PubMed]
  2. Renal dysfunction
    1. Serum Creatinine alone is unreliable as an acute marker of hypertensive injury
    2. Basic chemistry panel may be beneficial in acute Severe Hypertension
    3. Nishijima (2010) Am J Emerg Med 28(2): 235-42 [PubMed]
  3. Central nervous system
    1. Subarachnoid Hemorrhage
    2. Hypertensive Encephalopathy
      1. Results from Hypertension induced cerebral edema and micro-Hemorrhages
      2. May present with Headache, Vomiting, Dizziness and very high Blood Pressure
      3. Clinical diagnosis (no imaging studies make a definitive diagnosis)
    3. Headache
      1. CT Head indicated in acute onset of Headache with Vomiting and Severe Hypertension
      2. Headache in the absence of red flags does not require brain imaging

IX. Differential Diagnosis

  1. See Resistant Hypertension
  2. Hypertensive Emergency (Hypertensive Crisis)
    1. Rapid and progressive decompensation of vital organ function secondary to severely elevated Blood Pressure
    2. Acute life-threatening complications due to Severe Hypertension (acute Myocardial Infarction, Hemorrhagic CVA)
  3. Hypertensive Urgency
    1. Progressive end-organ damage risk factors (pre-existing CHF, Unstable Angina, Chronic Kidney Disease)
    2. Unlike Hypertensive Emergency there is no evidence of new injury secondary to Severe Hypertension
  4. Secondary Hypertension (less common)
    1. See Secondary Hypertension Causes
    2. Primary Hyperaldosteronism
    3. Obstructive Sleep Apnea
    4. Renal Artery Stenosis
    5. Hyperthyroidism or Hypothyroidism
    6. Cushing's Disease
    7. Pheochromocytoma
    8. Preeclampsia (20 weeks gestation to 6 weeks postpartum)
    9. Cerebrovascular Accident
  5. Medication or Substance Induced
    1. See Medication Causes of Hypertension
    2. Antihypertensive Withdrawal
    3. Alcohol Withdrawal
    4. Cocaine or other stimulant
    5. Serotonin Syndrome
    6. Anticholinergic Syndrome
    7. Malignant Hyperthermia

X. Management: Severe Hypertension Presentations (all have Blood Pressure >180/110)

  1. Hypertensive Emergency (Hypertensive Crisis)
    1. Rapid and progressive decompensation of vital organ function secondary to severely elevated Blood Pressure
    2. Acute life-threatening complications due to Severe Hypertension (acute Myocardial Infarction, Hemorrhagic CVA)
    3. Requires emergent and careful lowering of Blood Pressure (condition specific protocols exist)
    4. Typically requires admission to the ICU
  2. Hypertensive Urgency
    1. Progressive end-organ damage risk factors (pre-existing CHF, Unstable Angina, Chronic Kidney Disease)
    2. Unlike Hypertensive Emergency there is no evidence of new injury secondary to Severe Hypertension
    3. Start oral antihypertensive
    4. Consider admission in high risk cases
    5. Follow-up within 2 days with primary care
  3. Severe Uncontrolled Hypertension (Severe Asymptomatic Hypertension)
    1. No criteria met for Hypertensive Emergency or urgency as described above
    2. Elevated Blood Pressure in an asymptomatic patient with no signs of end-organ dysfunction
    3. Start oral antihypertensive
    4. Follow-up within 7 days with primary care

XI. Management: Hypertensive Emergency (Hypertensive Crisis)

  1. Approach
    1. Agents used should be based on local hospital guidelines
    2. What constitutes ideal agent selection is controversial and varies between institutions
      1. Agents described here offer one of several possible protocols
      2. Agents listed as second-line may be considered first-line at many hospitals
  2. First-line medications: No Heart Rate control needed
    1. Nicardipine
      1. Use as first line for most hypertensive emergencies
      2. Affects arterial vasodilation only (no effect on Heart Rate or Preload)
      3. Alternative: Clevidapine (new and improved, but more expensive version of Nicardipine)
  3. First-line medications: Heart Rate control needed
    1. Esmolol
      1. Use for Abdominal Aortic Aneurysm, Aortic Dissection or other conditions where rate control is needed
  4. Second-line medications
    1. Nitroprusside
      1. Difficult titration with resulting wide fluctuations in Blood Pressure effect
      2. Decreases Preload and causes reflex Tachycardia
    2. Labetalol
      1. Short acting and may not control Blood Pressure despite titration
      2. Use Nicardipine instead for most cases (however, Labetalol is preferred over Hydralazine and Clonidine)
    3. Nitroglycerin Drip
      1. Indicated in acute pulmonary edema and Severe Hypertension where direct vasodilation would be beneficial
  5. References
    1. Orman and Weingart in Majoewsky (2012) EM: RAP 12(2): 6-7

XII. Management: Historic indications for various antihypertensives for Hypertensive Crisis

  1. Management described above uses preferred medications
    1. This version listed only for completeness
  2. Hemorrhagic Stroke
    1. Nitroprusside
    2. Trimethaphan
    3. Labetalol
    4. Nicardipine
  3. Left Ventricular Heart Failure
    1. Nitroprusside
    2. Trimethaphan
    3. Avoid Labetalol
  4. Myocardial Infarction or Myocardial Ischemia
    1. Nitroglycerin Drip
    2. Labetalol
  5. Aortic Dissection
    1. Trimethaphan
    2. Nitroprusside
    3. Propranolol
  6. Pheochromocytoma
    1. Phentolamine
    2. Avoid Beta Blockers
  7. Preeclampsia or Eclampsia
    1. Magnesium Sulfate
    2. Hydralazine

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Ontology: Malignant Hypertension (C0020540)

Definition (MSH) A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
Concepts Disease or Syndrome (T047)
MSH D006974
SnomedCT 155301003, 286951002, 70272006
English Hypertension, Malignant, HYPERTENSION MALIGNANT, Malignant Hypertension, Accelerated hypertension, Hypertension malignant, Malignant hypertension NOS, Hypertension, Malignant [Disease/Finding], accelerated hypertension, Hypertension;malignant, hypertension malignant, hypertension (systemic) malignant, malignant hypertension (diagnosis), malignant hypertension, Malignant hypertension, Malignant hypertension (disorder)
Portuguese HIPERTENSAO MALIGNA, Hipertensão arterial maligna NE, Hipertensão arterial acelerada, Hipertensão maligna, Hipertensão Maligna
Spanish HIPERTENSION MALIGNA, Hipertensión maligna NEOM, hipertensión arterial maligna (trastorno), hipertensión arterial maligna, Hipertensión acelerada, Hipertensión maligna, Hipertensión Maligna
Italian Ipertensione accelerata, Ipertensione maligna NAS, Ipertensione maligna
Dutch hypertensie maligne, maligne hypertensie NAO, maligne hypertensie, progressieve hypertensie, Hypertensie, maligne, Maligne hypertensie
French Hypertension maligne SAI, HYPERTENSION MALIGNE, Hypertension artérielle accélérée, Hypertension maline, Hypertension artérielle maligne, Hypertension maligne
German maligne Hypertonie NNB, Hypertonie boesartig, HYPERTONIE MALIGNE, maligne Hypertonie, progressive Hypertonie, Hypertonie, maligne
Japanese 進行性高血圧, 悪性高血圧NOS, アクセイコウケツアツ, アクセイコウケツアツNOS, シンコウセイコウケツアツ, 高血圧-悪性, 悪性高血圧, 悪性高血圧症, 高血圧症-悪性
Swedish Hypertoni, malign
Czech hypertenze maligní, Maligní hypertenze NOS, Maligní hypertenze, Akcelerovaná hypertenze, zhoubná hypertenze
Finnish Pahanlaatuinen verenpainetauti
Russian GIPERTENZIIA ZLOKACHESTVENNAIA, ГИПЕРТЕНЗИЯ ЗЛОКАЧЕСТВЕННАЯ
Polish Nadciśnienie złośliwe
Hungarian Malignus hypertonia, Rosszindulatú hypertonia k.m.n., Rosszindulatú hypertonia, Accelerált hypertonia
Norwegian Malign hypertensjon

Ontology: Hypertensive crisis (C0020546)

Concepts Disease or Syndrome (T047)
SnomedCT 195225002, 50490005
Italian Crisi ipertensiva
Dutch crisis hypertensief, hypertensieve crisis
French Crise d'hypertension, Crise aiguë d'hypertension
Spanish crisis hipertensiva, Crisis hipertensiva
Czech Hypertenzní krize
English Crisis hypertensive, hypertensive crisis, crisis hypertensive, Hypertensive crisis, Hypertensive Crisis
Japanese コウケツアツクリーゼ, 高血圧クリーゼ
Hungarian Hypertoniás crisis, Hypertensiv crisis
Portuguese Crise hipertensiva
German hypertensive Krise

Ontology: Hypertensive emergency (C0745136)

Concepts Disease or Syndrome (T047)
SnomedCT 132721000119104
Italian Emergenza ipertensiva
Japanese 高血圧緊急症, コウケツアツキンキュウショウ
Czech Hypertenzní náhlá příhoda
English emergency hypertensive, emergencies hypertensive, hypertensive emergency, Hypertensive emergency (disorder), Hypertensive emergency
Hungarian Hypertensiv sürgősségi állapot
Spanish emergencia hipertensiva, emergencia hipertensiva (trastorno), Emergencia por hipertensión
Portuguese Emergência por hipertensão
Dutch hyperensief noodgeval
French Urgence hypertensive
German hypertensiver Notfall

Ontology: Hypertensive urgency (C0745138)

Concepts Disease or Syndrome (T047)
SnomedCT 443482000
Dutch hypertensieve urgentie
French Urgence d'origine hypertensive
German Hochdruckkrise
Italian Urgenza ipertensiva
Portuguese Urgência hipertensiva
Spanish Urgencia por hipertensión, urgencia hipertensiva (trastorno), urgencia hipertensiva
Japanese 高血圧切迫症, コウケツアツセッパクショウ
Czech Hypertenzní krize
English Hypertensive urgency (disorder), Hypertensive urgency, hypertensive urgency, hypertensive urgencies, hypertensive urgency (diagnosis)
Hungarian Sürgősséget igénylő HT állapot

Ontology: Uncontrolled hypertension (C1868885)

Concepts Disease or Syndrome (T047)
English Uncontrolled hypertension
Dutch oncontroleerbare hypertensie
French Hypertension incontrôlée
German unkontrollierte Hypertonie
Italian Ipertensione non controllata
Portuguese Hipertensão descontrolada
Spanish Hipertensión incontrolada
Japanese コントロールサレテイナイコウケツアツ, コントロールされていない高血圧
Czech Nekontrolovaná hypertenze
Hungarian Kontrollálatlan hypertonia