Cardiovascular Medicine Book

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Antihypertensive SelectionAka: Hypertension Monotherapy

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  1. See Also
    1. Hypertension
    2. Hypertension Criteria
    3. Hypertension Evaluation
  2. Step 1: Determine when and how to intervene
    1. Review Hypertension Risk Stratification
    2. Determine Hypertension Reduction Goal
  3. Step 2
    1. Consider Hypertension Combination Therapy
      1. For Refractory Hypertensive Populations
    2. Monotherapy
      1. Standard initial monotherapy choices
        1. Diuretics (e.g. Hydrochlorothiazide)
          1. If Diuretic is not first, it should be second
          2. Excellent adjunct to other antihypertensives
          3. Better outcomes than Lisinopril and Amlodipine
            1. Reduced risk of CVA, MI, CHF over other agents
            2. (2002) JAMA 288:2981
        2. Beta Blocker
        3. ACE Inhibitor
        4. Angiotensin Receptor Blocker
      2. Compelling reason for other antihypertensive
        1. AntiHypertensives for Specific Comorbid Diseases
        2. Antihypertensives for Specific Populations
      3. Agents to avoid for monotherapy
        1. Alpha blockers
        2. Hydralazine
        3. Minoxidil
        4. Calcium Channel Blockers
      4. Avoid if non-compliant (rebound Hypertension)
        1. Beta Blockers
        2. Clonidine
  4. Step 3
    1. Consider Hypertension Combination Therapy

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