Cardiovascular Medicine Book

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Antihypertensive Selection

Aka: Antihypertensive Selection, Hypertension Monotherapy
  1. See Also
    1. Hypertension
    2. Hypertension Criteria
    3. Hypertension Evaluation
  2. Step 1: Determine when and how to intervene
    1. Review Hypertension Risk Stratification
    2. Determine Hypertension Reduction Goal
  3. Step 2
    1. Consider Hypertension Combination Therapy
      1. For Refractory Hypertensive Populations
      2. Combination therapy to start appears to be more effective than starting with monotherapy
    2. Monotherapy
      1. Standard initial monotherapy choices
        1. Diuretics (e.g. Hydrochlorothiazide)
          1. If Diuretic is not first, it should be second
          2. Excellent adjunct to other antihypertensives
          3. Better outcomes than Lisinopril and Amlodipine
            1. Reduced risk of CVA, MI, CHF over other agents
            2. (2002) JAMA 288:2981-97
        2. Beta Blocker
        3. ACE Inhibitor
        4. Angiotensin Receptor Blocker
      2. Compelling reason for other antihypertensive
        1. AntiHypertensives for Specific Comorbid Diseases
        2. Antihypertensives for Specific Populations
      3. Agents to avoid for monotherapy
        1. Alpha blockers
        2. Hydralazine
        3. Minoxidil
        4. Calcium Channel Blockers
      4. Avoid if non-compliant (rebound Hypertension)
        1. Beta Blockers
        2. Clonidine
  4. Step 3
    1. Consider Hypertension Combination Therapy

Antihypertensive Agents (C0003364)

Definition (NCI) Any substance used in the treatment of acute or chronic hypertension regardless of pharmacological mechanism. Antihypertensive agents include diuretics, alpha-adrenergic and beta-adrenergic antagonists, angiotensin-converting enzyme inhibitors, calcium channel blockers, ganglionic blockers, and vasodilator agents.
Definition (MEDLINEPLUS)

High blood pressure, also called hypertension, usually has no symptoms. But it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. If you cannot control your high blood pressure through healthy lifestyle habits such as losing weight and reducing sodium in your diet, your doctor may prescribe medicines.

Blood pressure medicines work in different ways to lower blood pressure. Some remove extra fluid and salt from the body to lower blood pressure. Others slow down the heartbeat or relax and widen blood vessels. Often, two or more medicines work better than one.

NIH: National Heart, Lung, and Blood Institute

Definition (CSP) agent that reduces high blood pressure.
Definition (MSH) Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Concepts Pharmacologic Substance (T121)
MSH D000959
SnomedCT 1182007, 372586001
English Agents, Antihypertensive, antihypertensive agent, Antihypertensive Drugs, Agents, Anti-Hypertensive, Anti Hypertensive Agents, Anti Hypertensive Drugs, Anti Hypertensives, Anti-Hypertensive Agents, Anti-Hypertensive Drugs, Anti-Hypertensives, Antihypertensives, Drugs, Anti-Hypertensive, Drugs, Antihypertensive, Antihypertensive agent, NOS, Antihypertensive drug, NOS, HYPOTENSIVE AGENTS, Hypotensive agent, NOS, antihypertensives (medication), antihypertensive agents, antihypertensives, 811-813 HYPOTENSIVE AGENTS, anti hypertensive, antihypertensives drugs, anti hypertensive drug, anti-hypertensive drugs, hypotensive agent, antihypertensive drug, antihypertensive drugs, anti hypertensives, antihypertensive, hypotensive agents, anti-hypertensives, anti hypertensive drugs, blood pressure lowering drug, Antihypertensive Medicines, High blood pressure medicines, High Blood Pressure Medicines, Blood Pressure Medicines, Antihypertensive Agents, Antihypertensive drug, Antihypertensive, Hypotensive agent (product), Hypotensive agent (substance), Hypotensive agent, Antihypertensive agent, Hypotensive Agents, Hypotensive Drugs, Hypotensives, Antihypertensive Agent
French Agents antihypertenseurs, Médicaments antihypertenseurs, Anti-hypertenseurs, Antihypertenseurs
Swedish Blodtryckssänkande medel
Czech hypotenzíva, antihypertenzíva, hypotonika
Finnish Verenpainelääkkeet
Italian Farmaci antiipertensivi, Antiipertensivi
Russian GIPOTENZIVNYE SREDSTVA, ANTIGIPERTENZIVNYE SREDSTVA, АНТИГИПЕРТЕНЗИВНЫЕ СРЕДСТВА, ГИПОТЕНЗИВНЫЕ СРЕДСТВА
Croatian ANTIHIPERTENZIVI
Polish Leki obniżające ciśnienie, Leki hipotensyjne, Leki przeciwnadciśnieniowe
Japanese 血圧下降剤, 降圧剤, 抗高血圧症薬, 抗高血圧薬, 血圧降下剤, 血圧降下薬, 降圧物質, 降圧薬
Spanish agente antihipertensivo, agente hipotensor (producto), agente hipotensor (sustancia), agente hipotensor, droga antihipertensiva, Agentes Antihipertensivos
German Antihypertonika, Blutdrucksenkende Mittel, Antihypertensiva
Portuguese Anti-Hipertensivos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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