II. Indications
III. Contraindications
- See Angiotensin Receptor Blocker
- Glomerular Filtration Rate (GFR) <30 ml/min/1.73m2
IV. Mechanism
V. Dosing: Adults
-
Hypertension
- Start 16 mg orally daily
- Start 8 mg daily with concurrent Diuretic, elderly or GFR 30 to 60 ml/min/1.73m2
- Maximum 32 mg/day
- Start 16 mg orally daily
-
Congestive Heart Failure
- Start 4 mg orally daily
- May double dose every 2 weeks as needed
- Maximum 32 mg/day
VI. Dosing: Children
-
Hypertension
- Age 1 to 5 years
- Start 0.2 mg/kg oral suspension
- Target 0.05 to 0.4 mg/kg/day
- Age 6 to 16 years and weight <50 kg
- Start 4 to 8 mg/day
- Target 4 to 16 mg/day
- Age 6 to 16 years and weight >50 kg
- Start 8 to 16 mg/day
- Target 4 to 32 mg/day
- Maximum: 0.4 mg/kg/day up to 32 mg
- Age 1 to 5 years
VII. Adverse Effects
VIII. Safety
- See Angiotensin Receptor Blocker
- Pregnancy Category X
- Unknown Safety in Lactation
IX. Resources
X. References
- (2018) Presc Lett, Resource #340901, Angiotensin Receptor Blocker (ARB) Antihypertensive Dose Comparison
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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