Nephrology Book

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Serum CreatinineAka: Creatinine

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  1. Normal
    1. Adults
      1. Men: 0.8 to 1.3 mg/dl
      2. Women: 0.6 to 1.0 mg/dl
    2. Children (under age 20 years)
      1. Boys: 0.35 + (age in years)/40
      2. Girls: 0.35 + (age in years)/55
  2. Pathophysiology
    1. Increases by 1.0-1.5 mg/dl/day if no Renal Function
    2. Often unchanged until 25-50% of Renal Function lost
    3. Doubled Serum Creatinine implies 50% Renal Function
  3. Increased
    1. Renal insufficiency
    2. Decreased renal perfusion
    3. Urinary Tract Infections
    4. Skeletal muscle trauma or Rhabdomyolysis
    5. Ketonemia
    6. Diabetic Ketoacidosis
    7. Creatine Supplementation >15-20 grams per day
      1. May increase Serum Creatinine over 2.0
    8. Medications (Inhibit tubular secretion of creatinine)
      1. Aminoglycosides
      2. Cephalosporins
        1. Cefoxitin
        2. Cephalothin
      3. Hydantoin
      4. Diuretics
      5. Methyldopa
      6. Cimetidine
      7. Trimethoprim
  4. Decreased
    1. Decreased muscle mass
    2. Pregnancy

Creatinine (C0010294)

Definition (CSP)nitrogen compound in muscle, blood and urine that is the end product of creatine metabolism.
Definition (NCI)(cree-AT-ih-nin) A compound that is excreted from the body in urine. Creatinine levels are measured to monitor kidney function.
Definition (NCI)The breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.
ConceptsOrganic Chemical (T109) , Biologically Active Substance (T123)
EnglishCreatinine
Spanishcreatinina
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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