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Cephalosporin
- General
- Spectrum changes from first to third generation
- First Generation: Better Gram Positive Cocci coverage
- Third Generation: Better Gram Negative Rod coverage
- Contraindications
- Drug allergy to other Cephalosporin
- Type I Hypersensitivity Reaction to a Penicillin
- Class: First Generation Cephalosporins
- Oral Agents
- Cephalexin (Keflex)
- Cephradine (Velosef)
- Cefadroxil (Duricef)
- Parenteral Agents
- Cefazolin (Ancef)
- Organisms covered
- Gram Positive Cocci
- EKP Gram Negative Bacteria
- Class: Second Generation Cephalosporins
- Second Generation Broad-spectrum Cephalosporins
- Oral Agents
- Loracarbef (Lorabid)
- Cefprozil (Cefzil)
- Cefuroxime (Ceftin, Zinacef)
- Cefaclor (Ceclor)
- Organisms Covered
- Gram Positive Cocci
- EKP Gram Negative Bacteria
- Gram Negative Coccobacilli
- Second Generation Anti-anaerobe Cephalosporins
- Parenteral Agents
- Cefoxitin
- Cefotetan
- Cefamandole
- Organisms Covered
- Bacteroides fragilis
- Class: Third Generation Cephalosporins
- Third Generation Broad-Spectrum Cephalosporins
- Oral agents
- Cefixime (Suprax)
- Cefpodoxime (Vantin)
- Parenteral agents
- Cefotaxime (Claforan)
- Ceftizoxime (Cefizox)
- Ceftriaxone (Rocephin)
- Organisms Covered
- Gram Positive Cocci
- EKP Gram Negative Bacteria
- ESP Gram Negative Bacteria
- No Pseudomonas activity
- Third Generation Anti-Pseudomonal Cephalosporins
- Agents
- Ceftazidime (Fortaz)
- Organisms Covered
- Pseudomonas
- EKP Gram Negative Bacteria
- ESP Gram Negative Bacteria
- Poor Gram Positive Cocci coverage
- No Coccobacilli coverage
- Dosing: Adults
- Almost all Cephalosporins
- Typical Dose: 1-2 grams IV q8h
- Exceptions
- Ceftriaxone 1-2 grams IV q24 hours
- Cefotetan 1-2 grams IV q12 hours
- Dosing: Children
- Almost all Cephalosporins
- Typical dose: 100-200 mg/kg/day divided q8 hours
- Exceptions
- Ceftriaxone 75-100 mg/kg/day q24 hours
- Reducing Adverse Effects
- Least Diarrhea
- Lorabid
- Ceclor
- Cefzil
- Best taste
- Lorabid
- Suprax
- Vantin (under age 2 years)
Cephalosporins (C0007732)
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| Definition (MSH) | A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid. |
| Definition (CSP) | group of broad spectrum antibiotics which share the nucleus 7-aminocephalosporanic acid; antibacterial activity results from inhibition of the cross linking of peptidoglycan units in the cell wall. |
| Definition (NCI) | A family of antibiotic drugs that is used to treat a wide variety of bacterial infections. |
| Definition (NCI) | A class of broad-spectrum antibiotics first isolated from the Mediterranean fungus Acremonium (Cephalosporium acremonium). Cephalosporins inhibit mucopeptide synthesis by binding to penicillin binding proteins, causing inhibition of bacterial cell wall synthesis. (NCI) |
| Concepts | Organic Chemical (T109)
, Antibiotic (T195)
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| English | Cephalosporin, Cephalosporin Antibiotic, Cephalosporin Antibiotics, Cephalosporins |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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