Infectious Disease Book

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AminoglycosideAka: Gentamicin, Garamycin

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  1. Pharmacokinetics
    1. Maintain Trough <2 ug/ml
      1. Drawn immediately before next dose
    2. Maintain Peak at 5-8 ug/ml (4-6 ug/ml for child)
      1. Draw 1 hour after Intramuscular dose
    3. Indications for pharmacokinetics followed by PharmD
      1. Aminoglycoside use over 3 days
      2. Renal dysfunction
  2. Precautions
    1. Administer IV dose over 1 hour
    2. Adjust dosing per kinetics if >1-2 days use
  3. Dosing: Infants
    1. Term Infant
      1. Gentamycin 2.5 mg/kg/dose IV or IM q8 hours
    2. Preterm Infant
      1. Gestational Age >34 weeks and Weight over 2000 grams
        1. Gentamycin 2.5 mg/kg/dose IV or IM q12 hours
      2. Gestational Age <34 weeks
        1. Weight over 1250 grams
          1. Gentamycin 2.5 mg/kg/dose IV or IM q18 hours
        2. Weight Under 1250 grams
          1. Gentamycin 2.5 mg/kg/dose IV or IM q24 hours
      3. Age >7 days
        1. Gentamycin 2.5 mg/kg/dose IV or IM q12 hours
    3. Renal Impairment Adjustments
      1. Serum Creatinine 0.7 to 1.1
        1. Gentamycin 2.5 mg/kg/dose IV or IM q24 hours
      2. Serum Creatinine 1.1 to 1.3
        1. Gentamycin 2.5 mg/kg/dose IV or IM q36 hours
      3. Serum Creatinine > 1.3
        1. Gentamycin 2.5 mg/kg/dose IV or IM q48 hours
  4. Dosing: Children and adults
    1. Child
      1. Gentamicin 2 to 2.5 mg/kg IV or IM q8 hours
      2. Gentamicin 4.5 mg/kg IV q24 hours
    2. Adults
      1. Gentamicin 1-1.5 mg/kg IV or IM q8 hours or
      2. Gentamicin 5-7 mg/kg IV q24 hours
  5. Risk Factors for Nephrotoxicity
    1. Advanced age
    2. Prior renal insufficiency
    3. Dehydration
    4. Hypokalemia
    5. Hypomagnesemia
    6. Liver disease
    7. Sepsis
    8. Drug interactions with other nephrotoxic medications
      1. Cephalothin (Keflin) and other Cephalosporins
      2. Cyclosporin A
      3. Cisplatin
      4. NSAIDS
      5. ACE Inhibitors
      6. Methoxyflurane
      7. Loop Diuretics
      8. Amino acids

Antibiotics, Aminoglycoside (C0003233)

Definition (CSP)any of a group of antibiotics derived from various species of Streptomyces or produced synthetically; they inhibit protein synthesis by binding with the 30S ribosomal subunit.
Definition (NCI)A family of antibiotics that works against many types of bacteria and includes streptomycin, gentamicin, and neomycin. Aminoglycosides are used to treat bacterial infections.
Definition (NCI)A broad spectrum antibiotic family derived from Streptomyces containing aminoglycosides that bind to bacterial ribosomes, inhibiting protein synthesis.
ConceptsCarbohydrate (T118) , Antibiotic (T195)
EnglishAminoglycoside -class of antibiotic-, Aminoglycoside Agents, aminoglycoside antibiotic, aminoglycoside antibiotics, Aminoglycoside Drugs, Aminoglycosides
Parent ConceptsAntibiotics (C0003232), Glycosides (C0017977), Protein Synthesis Inhibitors (C0033671), Anti-Bacterial Agents (C0279516), Drug allergen (C1320237)
SourcesAOD, CSP, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Gentamicin Sulfate (USP) (C0546866)

Definition (MSH)A complex antibiotic substance produced by MICROMONOSPORA purpurea, with three components: gentamicin C1 (Gentamicin sulfate (salt)); gentamicin C2 (Gentamicin sulfate); and gentamicin C1A.
ConceptsCarbohydrate (T118) , Antibiotic (T195)
MSHD005839
EnglishGentamicin, Gentamicin Sulfate, GENTAMICIN SULFATE PREPARATION, Gentamicin sulphate, Gentamycin, GENTAMYCIN SULFATE, Gentamycin sulphate
Spanishsulfato de gentamicina
Parent ConceptsAnti-Bacterial Agents (C0279516), Gentamicins (C0017436), Duplicate concept (C1274013), Medicament patch test product (C1445114)
SourcesMSH, MTH, MTHFDA, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Garamycin (C0699088)

ConceptsCarbohydrate (T118) , Antibiotic (T195)
MSHD005839
EnglishGaramycin
SourcesMSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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