II. Definition: Preload

  1. End-diastolic wall tension (and end-diastolic volume) of the right ventricle
  2. Ventricular muscle stretches in response to increased pressure

III. Physiology: Frank-Starling Curve

  1. Normal heart
    1. Diastolic volume is the key determinent of ventricular contraction strength in the normal heart
    2. As end-diastolic volume (and pressure) increases, peak systolic pressure (contraction strength) increases
  2. Augmented contractility (e.g. inotrope infusion)
    1. Frank-Starling Curve shifts up and to the left
    2. For any given end-diastolic volume, the ventricular contraction (Stroke Volume) is increased
  3. Congestive Heart Failure
    1. Frank-Starling Curve shifts downward and flattens
    2. For any given end-diastolic volume in CHF, the ventricular contraction (Stroke Volume) is less than in a normal patient
    3. Increasing end-diastolic volume in CHF has adverse effects
      1. Stroke Volume increases minimally (flat part of Frank-Starling Curve)
      2. Peak systolic pressure increases significantly and results in vascular congestion
      3. Maladaptive long-term compensatory Mechanisms develop to maintain Stroke Volume
        1. Ventricle dilates (Cardiomyopathy) to allow for increased filling
        2. Ventricle becomes stiff (Diastolic Dysfunction)

IV. Precautions

  1. End diastolic pressure (e.g. CVP and Wedge Pressure) correlates poorly with end diastolic volume even in healthy patients
    1. Hence CVP and Wedge Pressure are unreliable markers of ventricular filling and volume status

V. References

  1. Marino (2014) ICU Book, 4th Ed Wolters-Kluwer p. 151-7

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