II. Definitions

  1. Abdominal Aortic Aneurysm
    1. Abdominal aorta diameter 3.0 cm or greater
  2. Abdominal Aortic Ectasia
    1. Abdominal aorta diameter 2.5 to 2.9 cm

III. Epidemiology

  1. Ruptured AAA results in 11,000 deaths per year
    1. Responsible for 4-5% of sudden deaths in the United States
  2. Age Distribution
    1. Age under 50 years old
      1. Uncommon
    2. Age over 60 years
      1. Incidence 5-7% of over 60 years old
      2. Accounts for 75% of aneurysms
    3. Age 65 to 74 years old
      1. Tenth leading cause of death
    4. Ages 74-84 years old
      1. Men: 12.5% Incidence of AAA
      2. Women: 5.2% Incidence of AAA
  3. Male:Female Ratio
    1. Age: 60-64 year old: 11:1
    2. Age: 85-90 year old: 3:1
  4. Ethnicity
    1. Black and hispanic patients are at lower risk of AAA

IV. Pathophysiology

  1. Elastin and collagen degradation in aorta wall
  2. Provoked by environmental stressors
    1. Inflammation (esp. Tobacco abuse)
    2. Possible association with Chlamydia pneumoniae
    3. Increased wall tension (e.g. Hypertension, PVD)

V. Risk Factors: AAA Development

  1. Similar to other Cardiovascular Risk Factors
  2. Tobacco abuse (90% of patients have used Tobacco)
  3. First degree relative has up to a 19% risk of AAA
  4. Coronary Artery Disease (including prior Myocardial Infarction)
  5. Peripheral Arterial Disease
  6. Hypertension
  7. Age over 65 years old
  8. Male gender

VI. Risk Factors: AAA Rupture

  1. Female gender
  2. Tobacco abuse
  3. Obstructive Lung Disease (FEV1 decreased)
  4. Hypertension

VII. Causes

  1. Associated with Atherosclerosis in only 25% of patients
  2. Aortic Dissection
  3. Mycotic Infection
  4. Cystic Medial Necrosis
  5. Ehlers-Danlos Syndrome

VIII. Presentation

  1. Asymptomatic in 75% of AAA
  2. Abrupt onset severe pain unrelieved by position change
    1. Classic: Back pain, pulsatile mass and Hypotension
    2. Suggestive of aneurysm enlargement or rupture
    3. Classic triad only present in 25-50% of cases
  3. Cryptic presentations are common
    1. Misdiagnosis as Diverticulitis, GI Bleed, Musculoskeletal cause is common (60% initial misdiagnosis rate)
    2. May present as referred pain to a wide range of regions (to chest, back and Scrotum)
    3. Microscopic Hematuria (and rarely Gross Hematuria) may lead to misdiagnosis of Renal Colic
  4. Aortic Rupture (20% present ruptured)
    1. Free Intraperitoneal Rupture (Catastrophic)
      1. Acute abdominal or back pain
      2. Flank Ecchymosis
      3. Cardiovascular Collapse (Hypotension)
      4. Sudden Death
    2. Sentinal Bleed (small posterolateral wall tear)
      1. Acute pain (constant)
      2. Syncope
      3. Pulsatile abdominal mass
      4. Hemodynamically stable with Tachycardia
      5. Needs Emergent Intervention before full rupture

IX. Symptoms

  1. Pain in Abdomen, Flank or Back
  2. Early satiety
  3. Nausea and Vomiting

X. Signs: Pulsatile abdominal mass

  1. Technique
    1. Mass occurs left of midline at level of Umbilicus
    2. Position patient supine, knees flexed, while exhaling
    3. May be associated with abdominal bruit
  2. Efficacy of palpation for pulsatile mass >3 cm
    1. Test Sensitivity: 68%
    2. Test Specificity: 75%
    3. Fink (2000) Arch Intern Med 160(6):833-6 [PubMed]
  3. Larger AAA has higher likelihood of palpation
    1. AAA 3-4 cm palpable in 29% of cases
    2. AAA 5 cm palpable in 76% of cases
    3. Lederle (1999) JAMA 281:77-82 [PubMed]

XI. Signs: Peripheral pulses

  1. Check pulse
    1. Femoral artery
    2. Popliteal artery
  2. Interpretation
    1. Bounding Pulse suggests possible AAA
    2. Peripheral artery aneurysmal swelling
      1. Femoral aneurysm predicts AAA in 85% of cases
      2. Popliteal aneurysm predicts AAA in 62% of cases

XIII. Diagnosis

  1. AAA is most commonly identified as an Incidental Imaging Finding
  2. Normal abdominal aorta diameter
    1. Male: 17-21 mm (infrarenal)
    2. Female: 15-19 mm (infrarenal)
  3. Abnormal Localized aortic dilatation
    1. Aortic diameter exceeds 1.5 times normal size
    2. Aortic diameter exceeds 30 mm

XIV. Imaging: General

  1. See Ultrasound in Abdominal Aortic Aneurysm
  2. See CT in Abdominal Aortic Aneurysm
  3. Incidental Findings on Abdominal XRay (low Specificity)
    1. Calcified AAA wall visible in only 67-75%
    2. Soft tissue mass
    3. Loss of psoas shadow
    4. Loss of renal outline

XV. Imaging: Screening for Abdominal Aortic Aneurysm

  1. Indications for one-time routine screening
    1. USPTF Guidelines (2014)
      1. General screening above age 75 years is not typically recommended due to likelihood of comorbidity
      2. Men 65 to 75 years old
        1. History of Tobacco abuse (>100 Cigarettes lifetime, Level B recommendation)
        2. Other AAA Risk Factor (see risk factors above, Level C recommendation)
      3. Women 65 to 75 years old
        1. History of Tobacco abuse (inconclusive, consider screening)
    2. Society for Vascular Medicine Guidelines
      1. Men age 60 to 85 years
      2. Women age 60 to 85 years with Cardiac Risk Factors
      3. Men and Women age >50 years and history of AAA in first degree relative
  2. First choice imaging study
    1. See Ultrasound in Abdominal Aortic Aneurysm
  3. Alternative for Obesity or excess intestinal gas
    1. Standard CT (see CT in Abdominal Aortic Aneurysm)

XVI. Imaging: Monitoring protocol for Abdominal Aortic Aneurysm

  1. Ultrasound in Abdominal Aortic Aneurysm
    1. Aorta diameter <3.0 cm
      1. No surveillance (although some consider rescreening if 2.5 to 2.9 cm)
    2. Aorta diameter 3.0 to 3.9 cm
      1. Repeat Ultrasound of AAA every 2 to 3 years
      2. Typical rate of expansion: 1-4 mm/year
    3. Aorta diameter 4.0 to 5.4 cm
      1. Repeat Ultrasound of AAA (or CT in Abdominal Aortic Aneurysm) every 6-12 months
      2. Consider Surgical Consultation for AAA 5.0 cm or greater (or faster rate of expansion)
      3. Typical rate of expansion: 3-5 mm/year
    4. Aorta diameter >5.4 cm
      1. Surgical Consultation for elective AAA repair
      2. Typical rate of expansion: 7-8 mm/year (for AAA >6.0 cm)
  2. CT in Abdominal Aortic Aneurysm
    1. Indications
      1. Surgeon will order on referral
      2. See surgery indications below
      3. Ultrasound aorta >5.4 cm
      4. Change >0.5 cm in 6 months or >1 cm in 1 year
    2. Interpretation
      1. Repeat Ultrasound q3 months if aorta <5.5 cm
      2. Vascular surgery consult for indications below
      3. Admit patients with aorta >8 cm on CT Abdomen

XVII. Imaging: Preoperative evaluation

  1. First Choice
    1. CT Angiogram
  2. Alternative in specific circumstances
    1. Abdominal Aortography
    2. MRI with MRA in abdominal aortic aneurysm

XVIII. Management: Surgical Repair

  1. Indications: Symptomatic Aneurysm
    1. Symptoms: Abdominal, back or Groin Pain with AAA
      1. Concurrent Hypotension suggests ruptured AAA
    2. Urgent surgical repair (high risk of rupture)
  2. Indications: Asymptomatic Aneurysm
    1. Aortic aneurysm diameter >5.4 cm
    2. AAA diameter 4-5 cm and
      1. Enlarging 0.5 cm in 6 months or
      2. Enlarging 1 cm in 1 year
    3. AAA diameter 7 cm with significant comorbidity
      1. Left Ventricular Dysfunction (CHF)
      2. Severe Chronic Obstructive Pulmonary Disease
      3. Noncorrectable symptomatic Coronary Artery Disease
  3. Operative Risk
    1. Myocardial Infarction (4.7% mortality)
    2. Mortality
      1. Elective repair: 3-5% (similar risk )
      2. Symptomatic Aneurysm: 26%
      3. Ruptured Aneurysm: 35-40%
      4. Sullivan (1990) J Vasc Surg 11:799-803 [PubMed]
  4. Operative techniques
    1. Open AAA repair (traditional)
      1. Higher 30 day mortality (4-5%) than endovascular repair (1-2%)
        1. However, endovascular repair benefit is absent by 1-2 years following repair
        2. Greenhalgh (2010) N Engl J Med 362(20): 1863-71 [PubMed]
      2. Endovascular repair has a higher rate of later complications
        1. Graft complications
        2. Second procedures required
    2. Endovascular AAA repair (Endograft)
      1. Optimal emergency stabilization procedure if infrarenal AAA (especially in elderly patients)
      2. Also consider if high risk with <2 years Life Expectancy
      3. Surveillance post procedure
        1. Requires CT at 1, 6 and 12 months after procedure
        2. Annual surveillance required after the first year
      4. Adverse events (10-15%)
        1. Lower 30 day mortality than open AAA repair
        2. Risk of blood leakage around endograft
        3. Also risk of stent graft or migration
        4. Similar 5 year mortality outcomes to open repair
      5. References
        1. (2005) Lancet 365:2179-86 [PubMed]
  5. Preoperative risk reduction
    1. See Preoperative Cardiovascular Evaluation
    2. Perioperative Beta Blocker
      1. Significantly decreases mortality
      2. Used bisoprolol 5 mg daily >1 week pre-surgery
      3. Goal Heart Rate: 60 (keep systolic BP >100)
      4. Poldermans (1999) N Engl J Med 341:1789-94 [PubMed]
    3. Tobacco Cessation
    4. Statins for lipid lowering
    5. COPD optimization
    6. Renal Function optimization in Chronic Kidney Disease

XIX. Prognosis

  1. Mortality from ruptured aneurysm: 90% (50% do not reach the hospital alive)
  2. Elective AAA Repair: 61% five year survival
  3. Risk of AAA rupture
    1. AAA <5.5 cm: 0.6-3.2% annual risk of AAA rupture
    2. AAA 5.5 - 6 cm: 9% annual risk of AAA rupture
    3. AAA 6 - 6.9 cm: 10% annual risk of AAA rupture (40% lifetime risk of rupture)
    4. AAA 7 cm: 33% annual risk of AAA rupture (50% lifetime risk of rupture)
  4. Course of small aortic aneurysms (<4 cm)
    1. Increase median of 2 mm per year (up to 8 mm/year)
    2. Biancari (2002) Am J Surg 183:53-5 [PubMed]
  5. Comorbid cardiopulmonary disease is common in AAA

XX. Prevention

  1. Slowing progression of AAA
    1. Tobacco Cessation
      1. Tobacco increases the incremental AAA growth rate by 0.4 mm per year
      2. Sweeting (2012) Br J Surg 99(5): 655-65 [PubMed]
    2. No strong evidence for specific antihypertensives or lipid lowering agents prior to repair
  2. Patient Education
    1. Indication for immediate evaluation in known AAA
    2. Pain in low back, groin, legs or buttocks

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Ontology: Aortic Aneurysm, Abdominal (C0162871)

Definition (NCI) Enlargement and ballooning of the vessel that supplies arterial blood to the abdomen, pelvis and legs.
Definition (MSH) An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
Concepts Disease or Syndrome (T047)
MSH D017544
SnomedCT 155422008, 233985008
English Aortic Aneurysm, Abdominal, Abdominal Aortic Aneurysms, Aneurysms, Abdominal Aortic, Aortic Aneurysms, Abdominal, AAA-Abdominal aortic aneurysm, ABDOMINAL AORTIC ANEURYSM, ANEURYSM, ABDOMINAL AORTIC, Abdominal Aortic Aneurysm, AAA (abdominal aorta aneurysm), aneurysm of abdominal aorta, aneurysm of abdominal aorta (diagnosis), Abdominal aneurysm, Aneurysm of abdominal aorta, abdominal aorta aneurysm, abdominal aortic aneurysm, AAA (abdominal aortic aneurysm), AAA, Aortic Aneurysm, Abdominal [Disease/Finding], Aneurysm;abdominal aortic, abdominal aneurysm, abdominal aortic aneurysms, abdominal aneurysms, aneurysm abdominal, abdominal aortic aneurysm (AAA), Aneurysm, Abdominal Aortic, AAA - Abdominal aortic aneurysm, Abdominal aortic aneurysm, Abdominal aortic aneurysm (disorder), abdominal; aneurysm, aneurysm; abdominal aorta, aneurysm; abdominal, aorta abdominalis; aneurysm
Dutch abdominaal aneurysma, aneurysma van aorta abdominalis, aneurysma aorta abdominalis, abdominaal; aneurysma, aneurysma; abdominaal, aneurysma; aorta abdominalis, aorta abdominalis; aneurysma, Aneurysma aortae abdominalis
French Anévrysme abdominal, AAA (Anévrisme de l'Aorte Abdominale), Anévrisme aortique abdominal, Anévrysme aortique abdominal, Anévrisme de l'aorte abdominale, Anévrysme de l'aorte abdominale, Anévrisme abdominal aortique, Anévrismes abdominaux aortiques, Anévrysme abdominal aortique, Anévrysmes abdominaux aortiques
German Aneurysma der Bauchaorta, Aneurysma, Aorta, abdominales, Aortenaneurysma, abdominales, Aneurysma, Bauchaorten-, Bauchaortenaneurysma
Italian Aneurisma dell'aorta addominale, Aneurisma addominale, Aneurisma aortico addominale
Portuguese Aneurisma abdominal, Aneurisma da aorta abdominal, Aneurisma da Aorta Abdominal
Spanish Aneurisma de la aorta abdominal, Aneurisma aórtico abdominal, Aneurisma abdominal, Aneurisma de la Aorta Abdominal, Aneurisma de Aorta Abdominal, Aneurisma Aórtico Abdominal, aneurisma de aorta abdominal (trastorno), aneurisma de aorta abdominal
Swedish Aortabråck, buk
Japanese フクブダイドウミャクリュウ, 大動脈瘤-腹部, 腹大動脈瘤, 腹部大動脈瘤
Finnish Vatsa-aortan aneurysma
Russian ANEVRIZMA AORTY BRIUSHNOI, AORTY BRIUSHNOI ANEVRIZMA, АНЕВРИЗМА АОРТЫ БРЮШНОЙ, АОРТЫ БРЮШНОЙ АНЕВРИЗМА
Czech Aneurysma břišní aorty, Břišní aneurysma, aorta abdominalis - aneurysma, aneurysma abdominalní aorty
Polish Tętniak aorty brzusznej
Croatian AORTNA ANEURIZMA, ABDOMINALNA
Hungarian Hasi aorta aneurysma, Aorta abdominalis aneurysmája, Abdominalis aneurysma
Norwegian Bukaortaaneurisme, Abdominalt aortaaneurisme