Obstetrics Book

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TocolyticAka: Tocolysis

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  1. See Also
    1. Preterm Labor Management
  2. Indications
    1. Preterm Labor
  3. Contraindications (See specific medications)
    1. Fetal Bradycardia <100
    2. Fetal Tachycardia >180
    3. Maternal Systolic Blood Pressure <90 mmHg
    4. Shortness of Breath
    5. Chest Pain
  4. Medications
    1. General Indications
      1. Stops labor for 24-48 hours
      2. Allows maternal transport or steroid doses above
    2. Magnesium Sulfate
      1. Does not prevent preterm birth
      2. Gyetvai (1999) Obstet Gynecol 94:869
    3. Terbutaline
      1. Effective at temporarily stopping contractions
        1. Results in shortest hospital triage stays
        2. Guinn (1997) Am J Obstet Gynecol 177:814
      2. Oral Terbutaline is not effective in Preterm Labor
        1. Lewis (1996) Am J Obstet Gynecol 175:834
    4. Ritodrine (only FDA approved Preterm Labor tocolytic)
      1. Not shown to be more effective than Placebo
      2. (1992) N Engl J Med 327:308
    5. Indomethacin (Indocin)
      1. Not recommended due to ductus arteriosus constriction
    6. Nifedipine (Procardia)
      1. Oral Nifedipine is not effective in Preterm Labor
  5. References
    1. Berkman (2003) Am J Obstet Gynecol 188:1648

Tocolysis (C0040348)

Definition (MSH)Any drug treatment modality designed to inhibit UTERINE CONTRACTION. It is used in pregnant women to arrest PREMATURE LABOR.
ConceptsTherapeutic or Preventive Procedure (T061)
MSHD015145
EnglishInhibition of uterine contractions, THER TOCOLYTIC, Tocolyses, Tocolysis, TOCOLYTIC THER, Tocolytic Therapies, Tocolytic Therapy, Tocolytic Treatment, Tocolytic Treatments
Spanishinhibicion de las contracciones uterinas, tocolisis
Parent ConceptsReproductive Techniques (C0035151), Medical procedure AND/OR service related to reproduction (C1293908)
SourcesMSH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Tocolytic Agents (C0040349)

Definition (MSH)Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.
Definition (CSP)class of drugs which inhibit premature labor.
ConceptsPharmacologic Substance (T121)
MSHD015149
Englishtocolytic agent, Tocolytic Agents, Tocolytic drug, Tocolytics
Spanishfarmaco tocolitico
Parent ConceptsPharmaceutical Preparations (C0013227), Reproductive Control Agents (C0035155), Reproductive system drug (C1277062)
SourcesCSP, MSH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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