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DextromethorphanAka: Benylin DM, Delsym

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  1. See Also
    1. Cough Suppressant
  2. Efficacy
    1. As effective as codeine for cough suppression
    2. But no more effective than Placebo in children
      1. Paul (2004) Pediatrics 114:e85
  3. Dosing
    1. Dextromethorphan (DM): 0.5 mg/kg up to 30 mg PO tid-qid
    2. Robitussin DM (15 mg/tsp)
      1. Adult: 2 tsp (10 ml) q4h
      2. Age 6 to 12 years: 1 tsp (5 ml) q4h
      3. Age 2 to 6 years: 1/2 tsp (2.5 ml) q4h
  4. Adverse effects
    1. Abuse potential (esp. in teens)
      1. Bryner (2006) Arch Pediatr Adolesc Med 160:1217
    2. Other (rare)
      1. Lethargy, stupor or coma
      2. Hyperexcitability
      3. Abnormal limb movements

Delsym (C0011218)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD003915
EnglishDelsym
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Dextromethorphan (C0011816)

Definition (MSH)Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Definition (NCI)A synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.
Definition (CSP)d-isomer of the codeine analog of levorphanol; dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center; this compound is an NMDA receptor antagonist (n-methyl-d-aspartate receptors) and acts as a noncompetitive channel blocker; it is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD003915
Englishd-Methorphan, Dextromethmorphan, Dextromethorphan, DEXTROMETHORPHAN PREPARATION, DXM, METHORPHAN D
Spanishdextrometmorfano, dextrometorfan, dextrometorfano
Parent ConceptsMorphinans (C0026548), Adjuvant Analgesic (C1510809), Levorphanol (C0023586), [RE302] NON-OPIOID-CONTAINING ANTITUSSIVES/EXPECTORANTS (C0973624), Morphinan cough suppressant (C0360196), Drug allergen (C1320237)
SourcesCSP, LNC, MSH, MTH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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