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TriazolamAka: Halcion

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  1. See Also
    1. Benzodiazepine
  2. Indication
    1. Insomnia
  3. Class
    1. Short Acting Benzodiazepine
  4. Dose
    1. Adult: 0.125 to 0.5 mg PO qhs
    2. Elderly: 0.125 mg PO qhs
  5. Pharmacokinetics
    1. Half-Life: 1.5-5.5 hours
  6. Background
    1. Weekly cost: $4.08
  7. Precautions
    1. Reports of Psychosis and Violence
      1. Associated with high dose halcion (>1 mg)
    2. Likely to be as safe as other Benzodiazepines

Triazolam (C0040879)

Definition (MSH)A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.
Definition (CSP)8-chloro-6-(2-chlorophenyl)-1-methyl- 1,2,4-triazolobenzodiazepine.
Definition (NCI)A triazolobenzodiazepinederivative with sedative-hypnotic property. Triazolam interacts directly with a specific site on the gamma-aminobutyric acid (GABA)-A-chloride-ionophore receptor complex located on the neuronal membrane. Binding causes allosteric modification of the receptor and modulation of its affinity for the inhibitory neurotransmitter GABA. This results in enhancement of synaptic actions of GABA and includes an increase in the frequency of chloride channel openings, increased chloride ion conductance, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD014229
Englishclorazolam, Greenstone Brand of Triazolam, Par Brand of Triazolam, Roxane Brand of Triazolam, Schein Brand of Triazolam, Triazolam, Triazolam Greenstone Brand, Triazolam Par Brand, TRIAZOLAM PREPARATION, Triazolam Roxane Brand, Triazolam Schein Brand, Triazolam UDL Brand, UDL Brand of Triazolam
Spanishtriazolam
Parent ConceptsBenzodiazepines (C0005064), Hypnotics and Sedatives (C0020592), [CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS (C0973503), Benzodiazepine sedative (C0360114)
SourcesAOD, CSP, LNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Halcion (C0733624)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD014229
EnglishHalcion, Pharmacia Brand of Triazolam, Pharmacia Spain Brand of Triazolam
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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