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Prolonged QT Interval due to MedicationAka: Drug-Induced Torsades de Pointes

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  1. See Also
    1. Prolonged QT
    2. Torsades de Pointes
  2. Risk Factors for Medication-Induced Torsades de Pointes
    1. Female gender
    2. Hypokalemia
    3. Severe Hypomagnesemia
    4. Bradycardia
    5. Atrial Fibrillation Cardioversion recently
    6. Congestive Heart Failure
    7. Concurrent Digoxin use
    8. Baseline QT Prolongation or subclinical long QT
  3. Medications causing Torsades de Pointes
    1. General
      1. Higher doses of predisposing drug raise risk
      2. Rapid drug administration raises risk
    2. Medications that more commonly cause Torsades
      1. Bepridil
      2. Disopyramide
      3. Dofetilide
      4. Ibutilide
      5. Procainamide
      6. Quinidine
      7. Sotalol
    3. Medications that less frequently cause Torsades
      1. Amiodarone
      2. Arsenic trioxide
      3. Chlorpromazine
      4. Cisapride
      5. Clarithromycin
      6. Domperidone
      7. Droperidol
      8. Erythromycin
      9. Halofantrine
      10. Haloperidol
      11. Lidoflazine
      12. Mesoridazine
      13. Methadone
      14. Pentamidine
      15. Pimozide
      16. Sparfloxacin
      17. Thioridazine
  4. References
    1. Roden (2004) N Engl J Med 350:1013

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