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Third Generation Fluoroquinolone
Aka: Third Generation Fluoroquinolone, Third Generation Quinolone, Levofloxacin, Levaquin, Sparfloxacin, Zagam, Gatifloxacin, Tequin, Moxifloxacin, Avelox- See Also
- Activity Spectrum
- Gram Negative Rod coverage (see other Fluoroquinolones)
- Atypical bacteria
- Moderate Gram Positive activity
- Indications
- Agents
- Levofloxacin (Levaquin)
- Moxifloxacin (Avelox)
- Sparfloxacin (Zagam)
- Low urine concentrations (avoid in UTI)
- Gatifloxacin (Tequin)
- Removed from U.S. market in 2006 due to fatalities (Hypoglycemia related)
- Adverse Effects
- See Fluoroquinolone
- Hypoglycemia with Gatifloxacin (Tequin)
- Has occurred in non-diabetics
- Contraindicated in Diabetes Mellitus
- References
| Medication Costs | ||
|---|---|---|
| Levofloxacin (on 2/9/2012 at DrugStore.com) | ||
| Levofloxacin 250mg Tablets | #50 for $30.99 | ($0.62/unit) |
| Levofloxacin 500mg Tablets | #50 for $35.99 | ($0.72/unit) |
| Levofloxacin 750mg Tablets | #20 for $25.99 | ($1.30/unit) |
| Levaquin (on 2/9/2012 at DrugStore.com) | ||
| Levaquin 750mg Tablets | #30 for $779.99 | ($26.00/unit) |
| Levaquin 250mg Tablets | #10 for $168.00 | ($16.80/unit) |
| Levaquin 500mg Tablets | #10 for $185.98 | ($18.60/unit) |
| Avelox (on 2/9/2012 at DrugStore.com) | ||
| Avelox 400mg Tablets | #30 for $545.98 | ($18.20/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
sparfloxacin (C0052585) |
|
|---|---|
| Concepts | Organic Chemical (T109) , Antibiotic (T195) |
| MSH | C061363 |
| SnomedCT | 387554008, 96090000 |
| English | sparfloxacin, sparfloxacin (medication), sparfloxacin [Chemical/Ingredient], Sparfloxacin, Sparfloxacin (product), Sparfloxacin (substance), SPARFLOXACIN |
| Spanish | esparfloxacino, esparfloxacina (producto), esparfloxacino (producto), esparfloxacina, esparfloxacino (sustancia), esparfloxacina (sustancia) |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Levofloxacin (C0282386) |
|
|---|---|
| Definition (NCI) | A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. |
| Definition (NCI) | A substance used to treat bacterial infections. It belongs to the family of drugs called quinolone antibiotics. |
| Definition (PDQ) | A broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37941&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37941&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1586" NCI Thesaurus) |
| Concepts | Organic Chemical (T109) , Antibiotic (T195) |
| MSH | D015242 |
| SnomedCT | 387552007, 96087006 |
| English | levofloxacin, levofloxacin (medication), LEVOFLOXACIN, Levofloxacin [Chemical/Ingredient], Ofloxacin, (S)-Isomer, Levofloxacin (product), Levofloxacin (substance), Levofloxacin |
| Portuguese | Levofloxacino |
| Spanish | Levofloxacino, levofloxacino (producto), levofloxacina, levofloxacino, levofloxacino (sustancia), levofloxacina (producto), levofloxacina (sustancia) |
| German | Levofloxacin |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
moxifloxacin (C0536495) |
|
|---|---|
| Definition (NCI) | A drug used to treat bacterial infections. It is a type of fluoroquinolone. |
| Definition (NCI) | A fluoroquinolone antibiotic with antibacterial activity. Moxifloxacin binds to and inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in inhibition of DNA replication and repair and cell death in sensitive bacterial species. |
| Concepts | Organic Chemical (T109) , Antibiotic (T195) |
| MSH | C104727 |
| SnomedCT | 371296007, 408008008, 412439003 |
| English | 1-cyclopropyl--7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, moxifloxacin, moxifloxacin [Chemical/Ingredient], Moxifloxacin product (product), Moxifloxacin product, MOXI, Moxifloxacin (product), Moxifloxacin, Moxifloxacin (substance), MOXIFLOXACIN |
| Spanish | Moxifloxacin, Moxifloxacin (product), moxifloxacina, producto (producto), moxifloxacina, producto, moxifloxacina (producto), moxifloxacino (sustancia), moxifloxacino, moxifloxacina, moxifloxacina (sustancia), moxifloxacino (producto) |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Levaquin (C0721336) |
|
|---|---|
| Definition (CHV) | brand name levofloxacin |
| Definition (CHV) | brand name levofloxacin |
| Definition (MSH) | Trade name for levofloxacin. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D015242 |
| English | levaquin, levaquin [brand name], Levaquin |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Zagam (C0724448) |
|
|---|---|
| Concepts | Organic Chemical (T109) , Antibiotic (T195) |
| MSH | C061363 |
| English | Zagam, sparfloxacin (Zagam), Aventis Behring brand of sparfloxacin, Bertek brand of sparfloxacin |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
gatifloxacin (C0753645) |
|
|---|---|
| Definition (NCI) | A synthetic 8-methoxyfluoroquinolone with antibacterial activity against a wide range of gram-negative and gram-positive microorganisms. Gatifloxacin exerts its effect through inhibition of DNA gyrase, an enzyme involved in DNA replication, transcription and repair, and inhibition of topoisomerase IV, an enzyme involved in partitioning of chromosomal DNA during bacterial cell division. |
| Concepts | Organic Chemical (T109) , Antibiotic (T195) |
| MSH | C078049 |
| SnomedCT | 371238005, 116349004 |
| English | 1-cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-, 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid, Gatifloxacin product, gatifloxacin (medication), gatifloxacin, gatifloxacin [Chemical/Ingredient], Gatifloxacin (product), Gatifloxacin (substance), Gatifloxacin, Gatifloxacin product (product), GATIFLOXACIN |
| Spanish | gatifloxacina (producto), gatifloxacina (sustancia), gatifloxacino (sustancia), gatifloxacina, gatifloxacino, gatifloxacino (producto) |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Avelox (C0875968) |
|
|---|---|
| Definition (NCI) | A drug used to treat bacterial infections. It is a type of fluoroquinolone. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C104727 |
| English | Avelox, avelox, Avalox, Bayer brand of moxifloxacin hydrochloride, Izilox, Actira |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Tequin (C0876180) |
|
|---|---|
| Concepts | Organic Chemical (T109) , Antibiotic (T195) |
| MSH | C078049 |
| English | Tequin, tequin |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |