Gastroenterology Book

http://www.fpnotebook.com/

DroperidolAka: Inapsine

Advertisement

  1. Indications: Not a first line drug due to QT Prolongation
    1. Antiemetic in refractory Vomiting
    2. Surgical or Diagnostic procedure
      1. Procedure related Nausea or Vomiting
      2. Conscious Sedation
    3. Migraine Headache
    4. Chemical restraint (e.g. violent patient)
  2. Contraindications
    1. Absolute contraindications
      1. QT Prolongation prior to use (>440 ms)
    2. Relative contraindications: Risk of QT Prolongation
      1. Congestive Heart Failure
      2. Bradycardia (Heart Rate <50 beats per minute)
      3. Concurrent Diuretic use
      4. Cardiac hypertrophy
      5. Hypokalemia
      6. Hypomagnesemia
      7. Other medication use associated with QT Prolongation
        1. Class I Antiarrhythmics
        2. Class III Antiarrhythmics
        3. Monoamine Oxidase Inhibitors
  3. Mechanism
    1. Butyrophenone Neuroleptic similar to Haloperidol
    2. Antiemetic activity via Dopamine antagonist
  4. Adverse effects
    1. QT Prolongation at therepeutic doses
    2. Sedation
      1. Usually resolves within 4 hours of dose
      2. Alertness may be decreased for 12 hours after dose
  5. Drug Interactions
    1. Other agents that prolong QT Interval (see above)
  6. Dosing
    1. Adults: 2.5 mg IM or IV slowly
    2. Children: 0.1 mg/kg IM or IV slowly
  7. Monitoring
    1. Baseline EKG
    2. Continuous cardiac monitoring for 3 hours after dose
  8. References
    1. (2002) Mosby's Drug Consult, p. 001117
    2. Hill (2000) Emerg Med Clin North Am 18(2):301
    3. Richman (2002) Am J Emerg Med 20(1):39

Droperidol (C0013136)

Definition (MSH)A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Definition (PDQ)A butyrophenone with anti-emetic, sedative and anti-anxiety properties. Although the exact mechanism through which droperidol exerts its effects is unknown, droperidol may block dopamine receptors in the chemoreceptor trigger zone (CTZ), which may lead to its anti-emetic effect. This agent may also bind to postsynaptic gamma-aminobutyric acid (GABA) receptors in the central nervous system (CNS), which increases the inhibitory effect of GABA and leads to sedative and anti-anxiety activities. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39227&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39227&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C458" NCI Thesaurus)
Definition (NCI)A butyrophenone with anti-emetic, sedative and anti-anxiety properties. Although the exact mechanism through which droperidol exerts its effects is unknown, droperidol may block dopamine receptors in the chemoreceptor trigger zone (CTZ), which may lead to its anti-emetic effect. This agent may also bind to postsynaptic gamma-aminobutyric acid (GABA) receptors in the central nervous system (CNS), which increases the inhibitory effect of GABA and leads to sedative and anti-anxiety activities.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishDroperidol, DROPERIDOL PREPARATION
Spanishdroperidol
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Inapsine (C0699335)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishInapsine, Taylor Brand of Droperidol
CreditsDerived from the NIH UMLS (Unified Medical Language System)



Navigation Tree