Mental Health Book

http://www.fpnotebook.com/

MidazolamAka: Versed

Advertisement

  1. See Also
    1. Benzodiazepine
  2. Indications
    1. Conscious Sedation
    2. Preoperative Sedation
      1. Induction
      2. Rapid Sequence Intubation
        1. Lack of IV Access
        2. Other intubation agents contraindicated
  3. Class
    1. Parenteral short acting Benzodiazepine
  4. Mechanism
    1. Sedative, Anxiolytic, and amnestic effects
    2. Antagonist: Flumazenil
  5. Dosing: Conscious Sedation
    1. Adult
      1. Intravenous: 1 mg IV slowly q2-3 min up to 5 mg
      2. Intramuscular: 5 mg (0.07 mg/kg) IM
    2. Child
      1. Intramuscular: 0.4 mg/kg/dose IM (Maximum: 10 mg)
      2. Intravenous: 0.1 mg/kg/dose IV (Maximum: 2 mg)
      3. Oral: 0.5 mg/kg/dose PO or PR (Maximum: 10 mg)
  6. Pharmacokinetics
    1. General
      1. Duration: 1-4 hours
      2. Half life: 2.5 hours
    2. Oral
      1. Onset: 20 to 30 minutes
      2. Peak: 40 minutes
    3. Intramuscular
      1. Onset: 5 to 7 minutes
      2. Peak: 10 to 15 minutes
    4. Intravenous
      1. Onset: 1.5 minutes
      2. Peak: 5 to 10 minutes
  7. Precautions
    1. Monitor closely with respiratory depression
    2. Have Ambubag and Oxygen available when administered
    3. Use with caution if risks for respiratory depression
      1. Concurrent Narcotic use
      2. Existing CNS depression
      3. Chronic lung disease
      4. Neuromuscular disorder
      5. Apnea history

Midazolam (C0026056)

Definition (MSH)A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
Definition (CSP)8-chloro-6-(2-fluorophenyl)-1-methyl- 4H- imidazo(1,5a)(1,4)benzodiazepine; short acting benzodiazepine sedative with high liability for abuse; used for preanesthesia sedation (USP lists as an injectable anesthetic).
Definition (NCI)A short-acting benzodiazepine derivative with an imidazole structure and with anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam exerts its effect by binding to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization and increases the inhibitory effect of GABA in the CNS. Midazolam may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD008874
EnglishMidazolam, MIDAZOLAM PREPARATION
Spanishmidazolam
Parent ConceptsBenzodiazepines (C0005064), Hypnotics and Sedatives (C0020592), [CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS (C0973503), Anesthetics, Intravenous (C0242904), Benzodiazepine sedative (C0360114)
SourcesAOD, CSP, LNC, MSH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Versed (C0042553)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD008874
EnglishVersed
SourcesMSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



Navigation Tree