Mental Health Book

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LorazepamAka: Ativan

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  1. Indications
    1. Anxiety Disorder
    2. Preanesthetic medication
  2. See Also
    1. Benzodiazepine
  3. Class
    1. Medium Acting Benzodiazepine
  4. Pharmacokinetics
    1. Half Life: 10-20 hours
  5. Dosing
    1. Dose: 0.5 to 2 mg IV, IM or PO every 6 to 8 hours
    2. Maximum Daily Dose: 4 mg
  6. Equivalent dosing (for Benzodiazepine Withdrawal)
    1. Valium = Dose x5.0
    2. Phenobarbital = Dose x15.0

Lorazepam (C0024002)

Definition (MSH)A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Definition (CSP)7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-hydroxy-1,4- benzodiazepin-2-one.
Definition (PDQ)A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C619" NCI Thesaurus)
Definition (NCI)A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD008140
EnglishLorazepam, LORAZEPAM PREPARATION
Spanishloracepam, lorazepam
Parent ConceptsBenzodiazepinones (C0005065), Benzodiazepines (C0005064), Tranquilizing Agents (C0040614), Antiemetics (C0003297), [CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS (C0973503), Lorazepam (C0024002), Benzodiazepine sedative (C0360114)
SourcesAOD, CSP, LCH, LNC, MSH, MTHFDA, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Ativan (C0699194)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD008140
EnglishAtivan, Baxter Brand of Lorazepam, Lorazepam Baxter Brand, Lorazepam Wyeth Brand, Orfidal Wyeth, Wyeth Brand of Lorazepam
SourcesAOD, MSH, MTH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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