II. Indications

  1. Anxiety Disorder
  2. Preanesthetic medication

III. See Also

IV. Class

  1. Medium Acting Benzodiazepine

V. Pharmacokinetics

  1. Half Life: 10-20 hours

VI. Dosing

  1. Dose: 0.5 to 2 mg IV, IM or PO every 6 to 8 hours
  2. Maximum Daily Dose: 4 mg

VII. Dosing: Equivalent (for Benzodiazepine Withdrawal)

  1. Valium = Dose x5.0
  2. Phenobarbital = Dose x15.0

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Cost: Medications

lorazepam (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
LORAZEPAM 0.5 MG TABLET Generic $0.02 each
LORAZEPAM 1 MG TABLET Generic $0.02 each
LORAZEPAM 2 MG TABLET Generic $0.05 each
LORAZEPAM 2 MG/ML ORAL CONCENT Generic $0.65 per ml
LORAZEPAM 2 MG/ML VIAL Generic $1.90 per ml
LORAZEPAM 20 MG/10 ML VIAL Generic $1.90 per ml
LORAZEPAM INTENSOL 2 MG/ML Generic $0.65 per ml
ativan (on 7/20/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
ATIVAN 0.5 MG TABLET Generic $0.02 each
ATIVAN 1 MG TABLET Generic $0.02 each

Ontology: Lorazepam (C0024002)

Definition (CHV) a drug used to treat anxiety
Definition (NCI_NCI-GLOSS) A drug that is used to treat anxiety and certain seizure disorders (such as epilepsy), and to prevent nausea and vomiting caused by chemotherapy. It belongs to the families of drugs called antiemetics and benzodiazepines.
Definition (NCI) A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.
Definition (CSP) 7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-hydroxy-1,4- benzodiazepin-2-one.
Definition (MSH) A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Definition (PDQ) A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C619" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008140
SnomedCT 323084002, 334011000, 321293002, 19225000, 387106007
LNC LP16176-7, MTHU003365
English Lorazepam, 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, Lorazepam [anxiolytic], Lorazepam [epilepsy], 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one, lorazepam, Lorazepam [anaesthesia], Lorazepam [anesthesia], LORAZEPAM, lorazepam (medication), Lorazepam [Chemical/Ingredient], LORazepam, Lorazepam [epilepsy] (product), Lorazepam [anesthesia] (product), Lorazepam [anxiolytic] (product), Lorazepam (product), Lorazepam (substance), Lorazepam [anesthesia] (substance), Lorazepam [anxiolytic] (substance), Lorazepam [epilepsy] (substance)
Swedish Lorazepam
Czech lorazepam
Finnish Loratsepaami
Russian ATIVAN, TAVOR, LORAZEPAM, АТИВАН, ЛОРАЗЕПАМ, ТАВОР
Japanese ロラゼパム
Croatian LORAZEPAM
Polish Lorazepam
Spanish lorazepam [anestésico] (producto), lorazepam [epilepsia] (producto), lorazepam [epilepsia], lorazepam [anestésico], lorazepam [ansiolítico] (producto), lorazepam [ansiolítico], loracepam (producto), loracepam (sustancia), loracepam, lorazepam (sustancia), lorazepam, Lorazepam
French Lorazépam
German Lorazepam
Italian Lorazepam
Portuguese Lorazepam

Ontology: Ativan (C0699194)

Definition (CHV) brand name of lorazepam
Definition (CHV) brand name of lorazepam
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008140
English Ativan [brand name], Baxter Brand of Lorazepam, Lorazepam Baxter Brand, Lorazepam Wyeth Brand, Orfidal Wyeth, Wyeth Brand of Lorazepam, Wyeth, Orfidal, Ativan, Témesta