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Lorazepam

Aka: Lorazepam, Ativan
  1. Indications
    1. Anxiety Disorder
    2. Preanesthetic medication
  2. See Also
    1. Benzodiazepine
  3. Class
    1. Medium Acting Benzodiazepine
  4. Pharmacokinetics
    1. Half Life: 10-20 hours
  5. Dosing
    1. Dose: 0.5 to 2 mg IV, IM or PO every 6 to 8 hours
    2. Maximum Daily Dose: 4 mg
  6. Equivalent dosing (for Benzodiazepine Withdrawal)
    1. Valium = Dose x5.0
    2. Phenobarbital = Dose x15.0

Lorazepam (C0024002)

Definition (CHV) a drug used to treat anxiety
Definition (NCI) A drug that is used to treat anxiety and certain seizure disorders (such as epilepsy), and to prevent nausea and vomiting caused by chemotherapy. It belongs to the families of drugs called antiemetics and benzodiazepines.
Definition (CSP) 7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-hydroxy-1,4- benzodiazepin-2-one.
Definition (MSH) A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Definition (NCI) A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.
Definition (PDQ) A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C619" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D008140
SnomedCT 321293002, 334011000, 323084002, 19225000, 387106007
English Lorazepam, 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, Lorazepam [anxiolytic], Lorazepam [epilepsy], 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one, lorazepam, Lorazepam [anaesthesia], Lorazepam [anesthesia], LORAZEPAM, Lorazepam [anxiolytic] (product), Lorazepam [epilepsy] (product), Lorazepam [anesthesia] (product), lorazepam (medication), Lorazepam [Chemical/Ingredient], LORazepam, Lorazepam (product), Lorazepam (substance), Lorazepam [anesthesia] (substance), Lorazepam [anxiolytic] (substance), Lorazepam [epilepsy] (substance)
Swedish Lorazepam
Czech lorazepam
Finnish Loratsepaami
Russian ATIVAN, TAVOR, LORAZEPAM, АТИВАН, ЛОРАЗЕПАМ, ТАВОР
Spanish lorazepam [epilepsia] (producto), lorazepam [anestésico], lorazepam [epilepsia], lorazepam [anestésico] (producto), lorazepam [ansiolítico] (producto), lorazepam [ansiolítico], loracepam (producto), loracepam (sustancia), loracepam, lorazepam (sustancia), lorazepam, Lorazepam
Japanese ロラゼパム
Croatian LORAZEPAM
Polish Lorazepam
French Lorazépam
German Lorazepam
Italian Lorazepam
Portuguese Lorazepam
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Ativan (C0699194)

Definition (CHV) brand name of lorazepam
Definition (CHV) brand name of lorazepam
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D008140
English Ativan [brand name], Baxter Brand of Lorazepam, Lorazepam Baxter Brand, Lorazepam Wyeth Brand, Orfidal Wyeth, Wyeth Brand of Lorazepam, Wyeth, Orfidal, Ativan, Témesta
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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