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Quetiapine

Aka: Quetiapine, Seroquel
  1. Class
    1. Atypical Antipsychotic (Second Generation agent)
    2. Neuroleptic
    3. Dibenzothiazepine Antipsychotic
  2. Indications
    1. Schizophrenia
    2. Psychosis in Dementia
    3. Mania (not FDA approved)
    4. Bipolar Disorder (not FDA approved)
    5. Autism (not FDA approved)
    6. Insomnia (not FDA approved)
  3. Dosing
    1. Adults
      1. Initial: 25 mg PO bid-tid
      2. Increase in 25-50 mg/day increments
      3. Target: 300-400 mg/day divided bid-tid
      4. Maximum dose: 750 mg/day
    2. Elderly
      1. Initial dose: 12.5 mg PO qhs
      2. Titrate up every few days (caution due to Sedation)
  4. Adverse Effects
    1. Sedation
    2. Headache
    3. Orthostatic Hypotension
    4. Cataract formation
  5. Drug Interactions
    1. Increase Antipsychotic levels (toxicity risk): Monitor for toxicity
      1. Clarithromycin
      2. Erythromycin
      3. Grapefruit juice
      4. Fluconazole
      5. Itraconazole
      6. Ketoconazole
      7. Quinidine
    2. Decrease Antipsychotic levels (lower efficacy)
      1. Barbiturates
      2. Carbamazepine
      3. Phenytoin
      4. Rifampin
      5. Theophylline
    3. Other effects
      1. Avoid concurrent use of other medications prolonging QT Interval
        1. See Prolonged QT Interval due to Medication
  6. Monitoring
    1. See Antipsychotic
    2. Screen for Cataract formation every 6 months
    3. Consider EKG, electrolyte and Magnesium monitoring due to QT Interval prolongation risk
  7. Pharmacokinetics
    1. Metabolized by Cytochrome P450 3A4

Seroquel (C0287163)

Definition (CHV) brand name of quetiapine, a drug used to treat schizophrenia and bipolar disorder
Definition (CHV) brand name of quetiapine, a drug used to treat schizophrenia and bipolar disorder
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C069541
English quetiapine (Seroquel), seroquel, seroquel [brand name], SEROquel, AstraZeneca Brand of Quetiapine Fumarate, Zeneca Brand of Quetiapine Fumarate, Seroquel
Sources
Derived from the NIH UMLS (Unified Medical Language System)


quetiapine (C0123091)

Definition (NCI) A dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C069541
SnomedCT 108443001, 386850001
English 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol, QUETIAPINE, quetiapine, quetiapine (medication), quetiapine [Chemical/Ingredient], QUEtiapine, Quetiapine, Quetiapine (product), Quetiapine (substance)
Spanish quetiapina (producto), quetiapina (sustancia), quetiapina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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