II. Mechanism

  1. Stimulates CNS adrenergic system
  2. Reduces food seeking behavior

III. Indication

  1. Short term (12 weeks per year) Obesity Management
  2. Physician discretion for indication to continue

IV. Classifications

  1. DEA Controlled Substance
    1. Class IV (Limited dependence liability)

V. Dosing

  1. Start: 8 mg orally three times daily
  2. Alternative: 15 to 37.5 mg orally daily 10 hours before sleep

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Cost: Medications

phentermine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
PHENTERMINE 15 MG CAPSULE Generic $0.21 each
PHENTERMINE 30 MG CAPSULE Generic $0.19 each
PHENTERMINE 37.5 MG CAPSULE Generic $0.20 each
PHENTERMINE 37.5 MG TABLET Generic $0.11 each

Ontology: Phentermine (C0031447)

Definition (NCI) A natural monoamine alkaloid derivative and a sympathomimetic stimulant with appetite suppressant property. Phentermine, which was part of the Fen-Phen anti-obesity medication, stimulates hypothalamic release of norepinephrine, a neurotransmitter involved in stress responses (fight-or-flight reactions), and reduces hunger sensation. Phentermine also causes the release of epinephrine or adrenaline outside of the brain, resulting in breakdown of stored fat.
Definition (MSH) A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Definition (CSP) central nervous system stimulant and sympathomimetic with actions and uses similar to dextroamphetamine; used in the treatment of obesity.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D010645
SnomedCT 373343009, 53480001
LNC LP16250-0, MTHU006735
English Phentermine, Benzeneethanamine, alpha,alpha-dimethyl-, phentermine, Phentermine [Chemical/Ingredient], 1,1-Dimethyl-2-phenylethylamine, 2-Phenyl-tert-butylamine, 2-Amino-2-methyl-1-phenylpropane, PHENTERMINE, Phenyl-tertiary-butylamine, Phentermine (product), Phentermine (substance)
Swedish Fentermin
Czech fentermin
Finnish Fentermiini
Russian FENTERMIN, ФЕНТЕРМИН
Japanese フェンテルミン, フェンテルミン塩酸塩, デュロミン, 塩酸フェンテルミン, イオナミン
Polish Fentermina
Spanish fentermina (producto), fentermina (sustancia), fentermina, Fentermina
French Phentermine
German Phentermin
Italian Fentermina
Portuguese Fentermina