Endocrinology Book

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Phentermine

Aka: Phentermine, Ionamin
  1. Trade Name
    1. Fastin
  2. Mechanism
    1. Stimulates CNS adrenergic system
    2. Reduces food seeking behavior
  3. Indication
    1. Short term (12 weeks per year) Obesity Management
    2. Physician discretion for indication to continue
  4. DEA Controlled Substance
    1. Class IV (Limited dependence liability)
  5. Dosing
    1. Start: 8 mg PO tid
    2. Alternative: 15 to 37.5 mg PO qd 10 hours before sleep

Phentermine (C0031447)

Definition (NCI) A natural monoamine alkaloid derivative and a sympathomimetic stimulant with appetite suppressant property. Phentermine, which was part of the Fen-Phen anti-obesity medication, stimulates hypothalamic release of norepinephrine, a neurotransmitter involved in stress responses (fight-or-flight reactions), and reduces hunger sensation. Phentermine also causes the release of epinephrine or adrenaline outside of the brain, resulting in breakdown of stored fat.
Definition (MSH) A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
Definition (CSP) central nervous system stimulant and sympathomimetic with actions and uses similar to dextroamphetamine; used in the treatment of obesity.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D010645
SnomedCT 373343009, 53480001
English Phentermine, Benzeneethanamine, alpha,alpha-dimethyl-, phentermine, Phentermine [Chemical/Ingredient], 1,1-Dimethyl-2-phenylethylamine, 2-Phenyl-tert-butylamine, 2-Amino-2-methyl-1-phenylpropane, PHENTERMINE, Phenyl-tertiary-butylamine, Phentermine (product), Phentermine (substance)
Swedish Fentermin
Czech fentermin
Finnish Fentermiini
Russian FENTERMIN, ФЕНТЕРМИН
Japanese フェンテルミン, フェンテルミン塩酸塩, デュロミン, 塩酸フェンテルミン, イオナミン
Polish Fentermina
Spanish fentermina (producto), fentermina (sustancia), fentermina, Fentermina
French Phentermine
German Phentermin
Italian Fentermina
Portuguese Fentermina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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