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TopiramateAka: Topamax

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  1. Indications
    1. Simple Partial Seizures
    2. Complex Partial Seizures
    3. Generalized Tonic Clonic Seizures
  2. Adverse Effects: Dose related
    1. Interferes with concentration and memory
    2. Confusion
    3. Sedation
    4. Lethargy
    5. Dizziness
    6. Ataxia
    7. Diplopia
    8. Tremor
    9. Nervousness
    10. Fatigue
    11. Depression
    12. Anorexia
    13. Dyspepsia
  3. Adverse Effects: Other
    1. Nephrolithiasis
    2. Narrow Angle Glaucoma
  4. Drug Interactions
    1. Other Seizure medications
  5. Dose: Adult
    1. Initial: 25-50 mg/day (consider start just qhs)
    2. Increase by 25-50 mg/day increments per week
    3. Target
      1. Adults: 400 mg/day divided bid
      2. Elderly: 200 mg/day divided bid
    4. Maximum dose: 1600 mg/day divided bid
  6. Dose: Child
    1. Initial: 1-3 mg/kg up to 25 mg PO qhs for 1 week
    2. Increase by 1-3 mg/kg/day to 25 mg increments per week
    3. Target range: 5-9 mg/kg/day divided bid
  7. Precautions
    1. Adjust dose if Creatinine Clearance <60 ml/min/sec

topiramate (C0076829)

Definition (NCI)A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishtopiramate, TOPIRAMATE PREPARATION
Spanishtopiramato
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Topamax (C0723778)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishCilag brand of topiramate, Epitomax, Janssen brand of topiramate, Ortho brand of topiramate, Topamax
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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