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OlanzapineAka: Zyprexa
- Class
- Neuroleptic
- Thienobenzodiazepine
- Indications
- Schizophrenia
- Acute mania phase of Bipolar Disorder
- No longer recommended for Psychosis in Dementia
- Higher risk of CVA and overall mortality in elderly
- Dosing
- Adults
- Start: 5 to 10 mg PO qd
- Increase in 5 mg increments weekly as tolerated
- Maximum: 20 mg/day
- Elderly
- Initial: 1.25 to 2.5 mg PO qd
- Titrate up as tolerated (watch for hypotension)
- Maximum: 10 mg/day
- Adverse effects
- Weight gain (4 kg)
- Sedation
- Orthostatic Hypotension
- Seizures (nearly 1% of patients)
- Overall higher mortality in elderly
- Hyperglycemia
- Increased risk of Diabetes Mellitus
- Koro (2002) BMJ 325:243
- Hyperlipidemia
- Koro (2002) Arch Gen Psychiatry 59:1021
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| Definition (NCI) | A synthetic derivative of thienobenzodiazepine with antipsychotic properties. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through a combination of dopamine and serotonin type 2 antagonism. |
| Definition (PDQ) | A synthetic derivative of thienobenzodiazepine with antipsychotic properties. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotonin, dopamine, muscarinic M1-5, histamine H1, and alpha1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through a combination of dopamine and serotonin type 2 antagonism. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=449664&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=449664&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47639" NCI Thesaurus) |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | olanzapine, OLANZAPINE PREPARATION |
| Spanish | olanzapina |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Eli Lilly brand of olanzapine, Lilly brand of olanzapine, Zyprexa |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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