http://www.fpnotebook.com/

Creatine PhosphokinaseAka: Creatine Kinase, Creatine Phosphotransferase, CPK, CK-MB, CK-MM, CK-BB

See Also
1. Serum Cardiac Markers
Physiology
1. Transferase class enzyme activated by magnesium
2. Catalyzes ATP energy storage as phosphocreatine
3. Phosphocreatine stored in muscle and brain
4. Phosphocreatine keeps ATP constant at Exercise start
Increased
1. Myocardial Infarction
2. Myocarditis
3. Rhabdomyolysis
4. Myositis
5. Crush injury or trauma
6. Dermatomyositis or Polymyositis
7. Vigorous Exercise
8. Muscular Dystrophy
9. Myxedema
10. Seizure
11. Malignant hyperthermia
12. Intramuscular injections
13. Cerebrovascular Accident
14. Pulmonary infarction
15. Pulmonary Embolus
16. Acute Aortic Dissection
Isoenzymes:
1. MB: Heart
2. MM: Skeletal muscle
3. BB:
  1. Brain
  2. Bowel infarction
  3. Neoplasm (Prostate, GI, Breast, Ovary, Lung, Brain)
Protocol: Acute Coronary Syndrome Evaluation
1. Obtain Serial CPK every 6 hours for total of 3 values
2. Fractionate to CK-MB only if CPK increased
3. CK-MB >5% of total CPK suggests Myocardial Infarction

Creatine Kinase (C0010287)
Definition (MSH)	A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Definition (NCI)	Encoded by human CKB Gene (ATP:Guanido Phosphotransferase Family), 381-aa 43-kDa cytoplasmic homodimer or heterodimer Creatine Kinase is a transferase involved in energy homeostasis that primarily catalyzes reversible formation of ATP and creatine from phosphocreatine. Important in muscle contraction, the reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue and BB from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. (NCI)
Concepts	Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
English	ADP Phosphocreatine Phosphotransferase, ATP Creatine Phosphotransferase, CKB, Creatine Kinase, Creatine Phosphokinase, EC 2.7.3.2
Spanish	creatina cinasa, creatina fosfocinasa, creatincinasa, creatinquinasa
Credits	Derived from the NIH UMLS (Unified Medical Language System)

PIK3C2A gene (C1418571)
Concepts	Gene or Genome (T028)
English	CPK, PIK3C2A, PIK3C2A gene
Credits	Derived from the NIH UMLS (Unified Medical Language System)